Comparison of the Effect of MCFA and LCFA on Postprandial Appetite and Lipemia

NCT05539742 | Completed

• 1 other identifier: 2022/6
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 2

Brief Summary

The main objective is to investigate if foods high in coconut oil (MCFA) or palm oil (LCFA) have different impacts on postprandial blood lipid levels and appetite via a visual analog scale (VAS).

Conditions

Lipemia

Keywords

Postprandial lipemia

Outcome Measures

Primary Outcomes (9)

• Anthropometric measurements ( Height)

  Standing height, without footwear, will be taken using stadiometer to the nearest 5mm

  baseline, pre-intervention, 1 day for each participant /during 3 months

• Anthropometric measurements (Weight)

  Bioelectrical impedance will be used to determine body weight

  baseline, pre-intervention, 1 day for each participant /during 3 months

• Anthropometric measurements (waist circumference)

  Waist circumference (WC) will be measured at the midway between the lowest ribs and the iliac crest using a standard tape to the nearest 1 cm

  baseline, pre-intervention, 1 day for each participant /during 3 months

• Anthropometric measurements (percentage body fat)

  Bioelectrical impedance will be used to determine body composition

  baseline, pre-intervention,1 day for each participant /during 3 months

• Biochemical measurements (Total cholesterol (TC))

  Up to 6 hours

  After the intervention / up to 3 months from collecting the samples

• Biochemical measurements (Low density lipoprotein cholesterol (LDL))

  Low-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals

  Up to 6 hours

• Biochemical measurements ( High density lipoprotein cholesterol (HDL))

  High-density lipoprotein cholesterol test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals

  Up to 6 hours

• Biochemical measurements (Triglyceride (TG))

  Triglyceride test will be performed after an overnight fast and 2, 4, and 6 hours after eating the meals

  Up to 6 hours

• Dietary intake (3-days food record)

  Participants will be asked to fill out a food record to track changes in their (intake) appetite

  one day

Study Arms (2)

Coconut oil

ACTIVE COMPARATOR

The coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits. Each participant will have ten minutes to consume biscuits with 250 ml of water. No other food will be consumed during the study period (6 hours). After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated. Then the participants will take the other treatment after a 1-week washout interval.

Dietary Supplement: Coconut oil

Palm oil

ACTIVE COMPARATOR

The palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits. Each participant will have ten minutes to consume biscuits with 250 ml of water. No other food will be consumed during the study period (6 hours). After that, participants will be allowed an ad libitum intake of standard meals. Each meal will be weighed before and after it is consumed, with the amount of food ingested being calculated. Then the participants will take the other treatment after a 1-week washout interval.

Dietary Supplement: Palm oil

Interventions

Coconut oil DIETARY_SUPPLEMENT

Coconut oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.

Coconut oil

Palm oil DIETARY_SUPPLEMENT

Palm oil will be given to each participant in the amount of 40 g, which will be incorporated into biscuits.

Palm oil

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18-50 years
• Males and females
• Apparently healthy
• Fasting triglyceride (TG) \< 2.5 mmol/L or 222 mg/dl at the time of screening.
• Body mass index (BMI) in normal range (18.5-24.9).
• Stable weight for at least 3 months

You may not qualify if:

• Consumption of lipid-lowering drugs or any medication that might affect appetite.
• Consumption of any supplement that may affect lipid metabolism or appetite on a regular basis for the past month.
• Regular consumption of two or more fish meals a week over the previous month.
• A history of diabetes, gastrointestinal , liver disease, congestive heart failure, stroke, myocardial infarction, coronary artery bypass graft or established atherosclerotic disease.
• Current smokers
• Pregnant , breastfeeding, postmenopausal or suffer from polycystic ovary syndrome (PCOS)
• Athlete
• Being on a diet or lifestyle changes for the past month.

Sponsors & Collaborators

• University of Jordan: lead

Study Sites (2)

The University of Jordan

Amman, 11942, Jordan

Location

The University of Jordan

Amman, Jordan

Location

Related Publications (23)

• Austin G, Ferguson JJ, Thota RN, Singh H, Burrows T, Garg ML. Postprandial lipaemia following consumption of a meal enriched with medium chain saturated and/or long chain omega-3 polyunsaturated fatty acids. A randomised cross-over study. Clin Nutr. 2021 Feb;40(2):420-427. doi: 10.1016/j.clnu.2020.06.027. Epub 2020 Jul 1.

  PMID: 32684486 BACKGROUND

• Abedi E, Sahari MA. Long-chain polyunsaturated fatty acid sources and evaluation of their nutritional and functional properties. Food Sci Nutr. 2014 Sep;2(5):443-63. doi: 10.1002/fsn3.121. Epub 2014 Jun 29.

  PMID: 25473503 BACKGROUND

• Behrouz V, Yari Z. A review on differential effects of dietary fatty acids on weight, appetite and energy expenditure. Crit Rev Food Sci Nutr. 2022;62(8):2235-2249. doi: 10.1080/10408398.2020.1852172. Epub 2020 Dec 1.

  PMID: 33261509 BACKGROUND

• Boateng L, Ansong R, Owusu WB, Steiner-Asiedu M. Coconut oil and palm oil's role in nutrition, health and national development: A review. Ghana Med J. 2016 Sep;50(3):189-196.

  PMID: 27752194 BACKGROUND

• Bozzetto L, Della Pepa G, Vetrani C, Rivellese AA. Dietary Impact on Postprandial Lipemia. Front Endocrinol (Lausanne). 2020 Jul 7;11:337. doi: 10.3389/fendo.2020.00337. eCollection 2020.

  PMID: 32733374 BACKGROUND

• Dias CB, Moughan PJ, Wood LG, Singh H, Garg ML. Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness. Lipids Health Dis. 2017 Sep 18;16(1):178. doi: 10.1186/s12944-017-0568-5.

  PMID: 28923057 BACKGROUND

• Folwaczny A, Waldmann E, Altenhofer J, Henze K, Parhofer KG. Postprandial Lipid Metabolism in Normolipidemic Subjects and Patients with Mild to Moderate Hypertriglyceridemia: Effects of Test Meals Containing Saturated Fatty Acids, Mono-Unsaturated Fatty Acids, or Medium-Chain Fatty Acids. Nutrients. 2021 May 20;13(5):1737. doi: 10.3390/nu13051737.

  PMID: 34065380 BACKGROUND

• Karupaiah T, Tan CH, Chinna K, Sundram K. The chain length of dietary saturated fatty acids affects human postprandial lipemia. J Am Coll Nutr. 2011 Dec;30(6):511-21. doi: 10.1080/07315724.2011.10719997.

  PMID: 22331686 BACKGROUND

• Kaviani S, Cooper JA. Appetite responses to high-fat meals or diets of varying fatty acid composition: a comprehensive review. Eur J Clin Nutr. 2017 Oct;71(10):1154-1165. doi: 10.1038/ejcn.2016.250. Epub 2017 Jan 18.

  PMID: 28098139 BACKGROUND

• Khaw KT, Sharp SJ, Finikarides L, Afzal I, Lentjes M, Luben R, Forouhi NG. Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. BMJ Open. 2018 Mar 6;8(3):e020167. doi: 10.1136/bmjopen-2017-020167.

  PMID: 29511019 BACKGROUND

• Maher T, Sampson A, Goslawska M, Pangua-Irigaray C, Shafat A, Clegg ME. Food Intake and Satiety Response after Medium-Chain Triglycerides Ingested as Solid or Liquid. Nutrients. 2019 Jul 17;11(7):1638. doi: 10.3390/nu11071638.

  PMID: 31319633 BACKGROUND

• Ma WY, Yang CY, Shih SR, Hsieh HJ, Hung CS, Chiu FC, Lin MS, Liu PH, Hua CH, Hsein YC, Chuang LM, Lin JW, Wei JN, Li HY. Measurement of Waist Circumference: midabdominal or iliac crest? Diabetes Care. 2013 Jun;36(6):1660-6. doi: 10.2337/dc12-1452. Epub 2012 Dec 28.

  PMID: 23275359 BACKGROUND

• Moneeb AHM, Hammam ARA, Ahmed AKA, Ahmed ME, Alsaleem KA. Effect of fat extraction methods on the fatty acids composition of bovine milk using gas chromatography. Food Sci Nutr. 2021 May 4;9(6):2936-2942. doi: 10.1002/fsn3.2252. eCollection 2021 Jun.

  PMID: 34136161 BACKGROUND

• Montoya C, Cochard B, Flori A, Cros D, Lopes R, Cuellar T, Espeout S, Syaputra I, Villeneuve P, Pina M, Ritter E, Leroy T, Billotte N. Genetic architecture of palm oil fatty acid composition in cultivated oil palm (Elaeis guineensis Jacq.) compared to its wild relative E. oleifera (H.B.K) Cortes. PLoS One. 2014 May 9;9(5):e95412. doi: 10.1371/journal.pone.0095412. eCollection 2014.

  PMID: 24816555 BACKGROUND

• Panth N, Abbott KA, Dias CB, Wynne K, Garg ML. Differential effects of medium- and long-chain saturated fatty acids on blood lipid profile: a systematic review and meta-analysis. Am J Clin Nutr. 2018 Oct 1;108(4):675-687. doi: 10.1093/ajcn/nqy167.

  PMID: 30239550 BACKGROUND

• Panth N, Dias CB, Wynne K, Singh H, Garg ML. Medium-chain fatty acids lower postprandial lipemia: A randomized crossover trial. Clin Nutr. 2020 Jan;39(1):90-96. doi: 10.1016/j.clnu.2019.02.008. Epub 2019 Feb 16.

  PMID: 30824268 BACKGROUND

• Pirillo A, Norata GD, Catapano AL. Postprandial lipemia as a cardiometabolic risk factor. Curr Med Res Opin. 2014 Aug;30(8):1489-503. doi: 10.1185/03007995.2014.909394. Epub 2014 May 2.

  PMID: 24673475 BACKGROUND

• Schonfeld P, Wojtczak L. Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res. 2016 Jun;57(6):943-54. doi: 10.1194/jlr.R067629. Epub 2016 Apr 14.

  PMID: 27080715 BACKGROUND

• Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L. The role of short-chain fatty acids in health and disease. Adv Immunol. 2014;121:91-119. doi: 10.1016/B978-0-12-800100-4.00003-9.

  PMID: 24388214 BACKGROUND

• Teng KT, Chang CY, Kanthimathi MS, Tan AT, Nesaretnam K. Effects of amount and type of dietary fats on postprandial lipemia and thrombogenic markers in individuals with metabolic syndrome. Atherosclerosis. 2015 Sep;242(1):281-7. doi: 10.1016/j.atherosclerosis.2015.07.003. Epub 2015 Jul 7.

  PMID: 26232169 BACKGROUND

• Tvrzicka E, Kremmyda LS, Stankova B, Zak A. Fatty acids as biocompounds: their role in human metabolism, health and disease--a review. Part 1: classification, dietary sources and biological functions. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2011 Jun;155(2):117-30. doi: 10.5507/bp.2011.038.

  PMID: 21804620 BACKGROUND

• Zentek J, Buchheit-Renko S, Ferrara F, Vahjen W, Van Kessel AG, Pieper R. Nutritional and physiological role of medium-chain triglycerides and medium-chain fatty acids in piglets. Anim Health Res Rev. 2011 Jun;12(1):83-93. doi: 10.1017/S1466252311000089.

  PMID: 21676342 BACKGROUND

• Jadallah R, Hammad SS. Comparison of the effect of medium-chain fatty acids and long-chain fatty acids on postprandial appetite and lipemia: a randomised crossover trial. BMJ Nutr Prev Health. 2024 Dec 11;7(2):e001029. doi: 10.1136/bmjnph-2024-001029. eCollection 2024.

  PMID: 39882282 DERIVED

MeSH Terms

Conditions

Hyperlipidemias

Interventions

Coconut Oil; Palm Oil

Condition Hierarchy (Ancestors)

Dyslipidemias; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Dietary Fats; Fats; Lipids; Plant Oils; Oils; Plant Preparations; Biological Products; Complex Mixtures

Study Officials

• Shatha S Hammad, PhD

  The University of Jordan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: randomized crossover single-blinded intervention study

Study Record Dates

• First Submitted: June 13, 2022
• First Posted: September 14, 2022
• Study Start: June 1, 2022
• Primary Completion: October 1, 2022
• Study Completion: November 1, 2022
• Last Updated: August 29, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

JO (2)