Comparison of Analgesic Effect and Postoperative Recovery of SAPB Combined With ESPB and TPB After Thoracoscopic Surgery

NCT05538429 | Unknown DMC

• 1 other identifier: 1000012129
• Study Type: interventional
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

After thoracoscopic surgery, patients still face moderate to severe pain. How to effectively control pain and promote postoperative recovery of patients is a challenging problem. Thoracic paraspinal block is effective in controlling pain after thoracoscopic surgery, but it also carries the risk of difficulty in operation and puncture of the pleura. In recent years, erector spinal plane block and serratus anterior plane block have been used for postoperative analgesia after thoracoscopic surgery. The purpose of this study was to explore whether erector spinal plane combined with serratus anterior plane block can replace thoracic paravertebral block and provide a more complete analgesia after thoracoscopic surgery. Therefore, this study is of great clinical significance.

Conditions

Thoracoscopic Surgery; Nerve Block

Outcome Measures

Primary Outcomes (1)

• The dose of opioids used

  dosage of analgesic pump

  24 hours after surgery

Secondary Outcomes (6)

• The dose of opioids used

  1hour, 2hours, 4hours, 8hours and 48hours postoperatively after surgery

• The number of survival analgesia

  1hour, 2hours, 4hours, 8hours, 24hours and 48hours after surgery

• VAS scores at resting and coughing state

  1hour, 2hours, 4hours, 8hours, 24hours and 48hours after surgery

• pulmonary function indexes

  Preoperative, postoperative 1hour, postoperative 4hours and postoperative 24hours

• QOR-15 scores

  before and 24 hours after surgery

Study Arms (2)

ESPB&SAPB

EXPERIMENTAL

erector spinal plane block combined with serratus anterior plane block

Procedure: erector spinal plane combined with serratus anterior plane block

TPVB

ACTIVE COMPARATOR

thoracic paravertebral block

Procedure: erector spinal plane combined with serratus anterior plane block

Interventions

erector spinal plane combined with serratus anterior plane block PROCEDURE

The experimental group received ultrasound-guided erector spinal block combined with serratus anterior plane block, and erector spinal block was performed at the T5 and T7 levels with 10ml 0.4% ropivacaine for each level, and 20ml 0.4% ropivacaine for serratus anterior plane block. The control group received ultrasound-guided thoracic paravertebral block at T5 and T7 levels, respectively, with 20ml 0.4% ropivacaine at each level.

Also known as: thoracic paravertebral block

ESPB&SAPB; TPVB

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• American ASA Grade I-III;
• Age: 18 \~ 70 years old;
• BMI 19 \~ 28kg/m2;
• \. Patients with elective thoracoscopic partial pneumonectomy under general anesthesia;
• Informed Consent has been signed.

You may not qualify if:

• Use opioid analgesics on a daily basis or have a history of opioid abuse;
• History of ipsilateral thoracotomy;
• Allergic to any of the drugs used in the study, or have a history of drug allergy;
• Mental or nervous system diseases, motor or sensory deficits;
• there is coagulation dysfunction;
• \. Cognitive dysfunction, unable to cooperate with research;
• \. Severe renal, hepatic or cardiac dysfunction;
• \. Chest wall and spine trauma, infection, deformity and other cases where nerve block cannot be performed;
• \. Investigators consider other reasons unsuitable for clinical trial participants;
• \. Patients refuse to participate.

Sponsors & Collaborators

• Zhangyi: lead

Study Sites (1)

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology.

Wuhan, Hubei, 430030, China

RECRUITING

Central Study Contacts

Yi Zhang, Dr.

CONTACT

13986039131; doc_zhang18@163.com

Xuan Mo

CONTACT

18776768640; mx1173572700@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 27, 2022
• First Posted: September 13, 2022
• Study Start: June 1, 2021
• Primary Completion: October 1, 2022
• Study Completion: November 1, 2022
• Last Updated: September 13, 2022

Record last verified: 2022-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)