Continuous Infusion and Intermittent Bolus Adductor Canal Block for Total Knee Arthroplasty
1 other identifier
interventional
66
1 country
1
Brief Summary
The investigators believed the analgesic efficacy of adductor canal block on patients receiving total knee arthroplasty. However, the analgesic effects of different delivery regimens and duration of effects are variable. The investigators hypothesize that using continuous infusion and shorter interval bolus of local anesthetics to perform adductor canal block will reduce pain scale and opioid consumption in patients receiving total knee arthroplasty compared with longer interval bolus of local anesthetics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Nov 2022
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 21, 2022
CompletedFirst Posted
Study publicly available on registry
August 26, 2022
CompletedStudy Start
First participant enrolled
November 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2024
CompletedApril 5, 2024
April 1, 2024
1.7 years
August 21, 2022
April 4, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Accumulated morphine consumption
Additional morphine prescription
In postoperative 48 hours
Secondary Outcomes (5)
Numerical pain scale at rest
In postoperative 2 days
Numerical pain scale during knee flexion
In postoperative 2 days
Percentage of muscle power decrement
In postoperative 2 days
Postoperative nausea and vomiting
In postoperative 2 days
Event of falling down
In postoperative 2 days
Other Outcomes (2)
Opioid related side effect
In postoperative 2 days
Nerve block related complication
In postoperative 2 days
Study Arms (3)
Continuous infusion
EXPERIMENTALadductor canal block with continuous infusion of 0.25% bupivacaine 3.5 ml per hour for 2 days postoperatively
12hrs intermittent bolus
ACTIVE COMPARATORadductor canal block with intermittent bolus of 0.25% bupivacaine 21 ml every 12 hours for 2 days postoperatively
6hrs intermittent bolus
EXPERIMENTALadductor canal block with intermittent bolus of 0.25% bupivacaine 21 ml every 6 hours for 2 days postoperatively
Interventions
adductor canal block with 0.25% bupivacaine
Eligibility Criteria
You may qualify if:
- Adults receiving unilateral total knee arthroplasty under spinal anesthesia
- American society of anesthesiologists 1-3
You may not qualify if:
- Could not cooperate
- Allergy to medicines used in the study
- Chronic pain
- Long term opioid use
- Neuromuscular disease
- Surgical complication: massive bleeding, postoperative ICU, unanticipated procedure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Cheng Kung University Hospital
Tainan, Taiwan
Related Publications (4)
Monahan AM, Sztain JF, Khatibi B, Furnish TJ, Jaeger P, Sessler DI, Mascha EJ, You J, Wen CH, Nakanote KA, Ilfeld BM. Continuous Adductor Canal Blocks: Does Varying Local Anesthetic Delivery Method (Automatic Repeated Bolus Doses Versus Continuous Basal Infusion) Influence Cutaneous Analgesia and Quadriceps Femoris Strength? A Randomized, Double-Masked, Controlled, Split-Body Volunteer Study. Anesth Analg. 2016 May;122(5):1681-8. doi: 10.1213/ANE.0000000000001182.
PMID: 26863502RESULTThapa D, Ahuja V, Verma P, Gombar S, Gupta R, Dhiman D. Post-operative analgesia using intermittent vs. continuous adductor canal block technique: a randomized controlled trial. Acta Anaesthesiol Scand. 2016 Nov;60(10):1379-1385. doi: 10.1111/aas.12787. Epub 2016 Sep 4.
PMID: 27592690RESULTJaeger P, Baggesgaard J, Sorensen JK, Ilfeld BM, Gottschau B, Graungaard B, Dahl JB, Odgaard A, Grevstad U. Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial. Anesth Analg. 2018 Jun;126(6):2069-2077. doi: 10.1213/ANE.0000000000002747.
PMID: 29293181RESULTJagannathan R, Niesen AD, D'Souza RS, Johnson RL. Intermittent bolus versus continuous infusion techniques for local anesthetic delivery in peripheral and truncal nerve analgesia: the current state of evidence. Reg Anesth Pain Med. 2019 Apr;44(4):447-451. doi: 10.1136/rapm-2018-100082. Epub 2019 Feb 3.
PMID: 30914472RESULT
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
WEI-TENG WENG, MD
Department of Anesthesiology, National Cheng Kung University Hospital, Taiwan
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Attending Physician of Anesthesiology
Study Record Dates
First Submitted
August 21, 2022
First Posted
August 26, 2022
Study Start
November 1, 2022
Primary Completion
June 30, 2024
Study Completion
September 30, 2024
Last Updated
April 5, 2024
Record last verified: 2024-04