Volume Dependent Effect of Pericapsular Nerve Block

NCT05256056 | Completed

• 1 other identifier: 2021/516
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In PENG block technique, the local anesthetic agent is injected between the psoas tendon and the pubic ramus to block the sensory branches of the nerves which innervates the hip capsule for providing analgesia without causing muscle weakness. Since the PENG block is a facial plane block, it causes a volume dependent distribution. There are a few case reposts and cadaveric studies on volume dependent effect of analgesia and motor weakness of PENG block. In our study, we aimed to evaluate the clinical effects of the volume-dependent efficacy of PENG block.

Conditions

Post Operative Pain; Femur Fracture

Keywords

pericapsular nerve group block; femur fracture; postoperative analgesia

Outcome Measures

Primary Outcomes (2)

• visual analouge scale

  the VAS 0 means no pain, 10 means the worst pain possible

  up to 24 hours,

• pin-prick test

  the ability to determine the difference between sharp and dull.

  up to 20 minutes

Secondary Outcomes (2)

• cold sensation test

  up to 20 minutes

• presence of quadriceps motor block

  up to 24 hours

Study Arms (2)

Group A

EXPERIMENTAL

patients will be injected with 20 cc of 0.25% Bupivacaine

Drug: Bupivacain

Group B

EXPERIMENTAL

patients will be injected with 30 cc of 0.25% Bupivacaine.

Drug: Bupivacain

Interventions

Bupivacain DRUG

efficacy of bupivacaine in different volumes

Group A; Group B

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who will undergoing hip arthroplasty surgery
• Patients over the age of 18
• ASA I-II-III patients
• Patients who will be operated under spinal anesthesia

You may not qualify if:

• ASA IV patients, Pregnant women
• Patients who are not suitable for spinal anesthesia
• Patients diagnosed with Alzheimer's and dementia who cannot cooperate
• Patients who are not suitable for peripheral nerve block (patients with infection in the injection area, with local anesthetic allergy, with coagulopathy)
• Patients who do not want to participate in the study
• Patients under the age of 18
• Patients switched to general anesthesia

Sponsors & Collaborators

• Sisli Hamidiye Etfal Training and Research Hospital: lead

Study Sites (1)

Sisli Etfal Research and Training Hospital

Seyrantepe, Istanbul, 34567, Turkey (Türkiye)

Location

Related Publications (2)

• Pascarella G, Costa F, Del Buono R, Pulitano R, Strumia A, Piliego C, De Quattro E, Cataldo R, Agro FE, Carassiti M; collaborators. Impact of the pericapsular nerve group (PENG) block on postoperative analgesia and functional recovery following total hip arthroplasty: a randomised, observer-masked, controlled trial. Anaesthesia. 2021 Nov;76(11):1492-1498. doi: 10.1111/anae.15536. Epub 2021 Jul 1.

  PMID: 34196965 BACKGROUND

• Sandri M, Blasi A, De Blasi RA. PENG block and LIA as a possible anesthesia technique for total hip arthroplasty. J Anesth. 2020 Jun;34(3):472-475. doi: 10.1007/s00540-020-02768-w. Epub 2020 Mar 30.

  PMID: 32232662 BACKGROUND

MeSH Terms

Conditions

Pain, Postoperative; Femoral Fractures

Interventions

Bupivacaine

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Fractures, Bone; Wounds and Injuries; Leg Injuries

Intervention Hierarchy (Ancestors)

Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines

Study Officials

• leyla kılınç

  şişli etfal eğitim araştırma hastanesi

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Patients will be randomized using the closed envelope method. While the practitioner knows the interventions to be made, the data collector will collect the data without learning the patient's group.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: specialist medical doctor

Model Details: Group A patients will be injected with 20 cc of 0.25% Bupivacaine, and Group B patients will be injected with 30 cc of 0.25% Bupivacaine

Study Record Dates

• First Submitted: February 16, 2022
• First Posted: February 25, 2022
• Study Start: February 25, 2022
• Primary Completion: June 1, 2022
• Study Completion: June 1, 2022
• Last Updated: June 3, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)