Characterization of the Pattern of Consumption and Withdrawal Syndrome From Dual Cannabis and Tobacco Use

NCT05512091 | Unknown

• 1 other identifier: DUCATA_GAM-CaT_REF:2020I034
• Study Type: observational
• Target: 282
• Locations: 0 countries
• Sites: N/A

Brief Summary

Aims: To characterize the pattern of cannabis and tobacco use and withdrawal symptoms in people who start treatment for cannabis use disorders (exclusive cannabis, concurrent and/or simultaneous with various tobacco products) through an aplication game and considering the type of users. Methodology: Mixed-methods research composed of three studies. Study I: qualitative participatory action study aimed at exploring the experiences and preferences of the cannabis users on the use of apps. This information will be instrumental in the co-design of the app. Study II: prospective longitudinal study aimed to establish consumption patterns and transitions between substances and to validate the scale of cannabis withdrawal symptoms in the Spanish population. Sample size: expected RR=1.20, α =0.05, β= 0.20, losses= 20% (n=282). Study III: qualitative study to explore participants' experiences during the process of quitting cannabis and / or tobacco. Expected results: Characterization and prediction of variables that influence cannabis and tobacco cessation/ reduction and describe withdrawal symptoms according to consumption patterns with aim of improving the design of future interventions.

Conditions

Cannabis Dependence; Tobacco Use; Withdrawal Syndrome; Substance Abuse

Keywords

Cannabis; Tobacco; Treatment; Social network

Outcome Measures

Primary Outcomes (4)

• Cannabis use

  Number of participants that use several cannabis products (hashish, marijuana, etc.)

  Change between baseline and 6 weeks follow-up

• Tobacco use

  Number of participants that use several type of tobacco product/s

  Change between baseline and 6 weeks follow-up

• Abstinence from cannabis

  If a participant reduces or quits their cannabis use, we will ask for their presence of 16 withdrawal symptoms. Each symptom is scored from 0 (minimum) to 3 (maximum). Higher scores mean a worse outcome.

  Change between baseline and 6 weeks follow-up

• Abstinence from tobacco

  If a participant reduces or quits their tobacco use, we will ask for their presence of 6 withdrawal symptoms using the Fagerström test. The test has a minimum score of 0 and a maximum of 10. Higher scores mean a worse outcome.

  Change between baseline and 6 weeks follow-up

Secondary Outcomes (4)

• Motivation to quit

  Baseline

• Psychological assessment

  Baseline

• Self-perceived health status

  Baseline

• Social and cultural factors

  Baseline

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Smokers under treatment for cannabis substance abuse from the province of Barcelona in Catalonia (Spain)

You may qualify if:

• Smokers (at least 1cig./week)
• Undertreatment for Cannabis
• \>=18 years-old
• Under clinical follow-up
• Informed consent
• Have a Smartphone

You may not qualify if:

• Severe cognitive impairment
• month follow-up not guaranteed

Sponsors & Collaborators

• Cristina Martínez Martínez: lead
• Hospital Clinic of Barcelona: collaborator
• Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau: collaborator
• University of Barcelona: collaborator
• Public Health Agency of Barcelona: collaborator

Related Publications (2)

• Saura J, Enriquez M, Feliu A, Roca X, Mondon S, Barrio P, Andreu M, Segura L, Ballbe M, Fu M, Fernandez E, Martinez C; DuCATA clinical group. Consumption patterns and withdrawal symptoms in dual cannabis-tobacco users in Spain: Cross-sectional study. Addict Behav Rep. 2025 Dec 17;23:100656. doi: 10.1016/j.abrep.2025.100656. eCollection 2026 Jun.

  PMID: 41531671 DERIVED

• Saura J, Feliu A, Enriquez-Mestre M, Fu M, Ballbe M, Castellano Y, Pla M, Rosa N, Radeva P, Maestre-Gonzalez E, Cabezas C, Colom J, Suelves JM, Mondon S, Barrio P, Andreu M, Raich A, Bernabeu J, Vilaplana J, Roca Tutusaus X, Guydish J, Fernandez E, Martinez C. Patterns of Use and Withdrawal Syndrome in Dual Cannabis and Tobacco Users (DuCATA_GAM-CAT): Protocol for a Mixed Methods Study. JMIR Res Protoc. 2024 Sep 19;13:e58335. doi: 10.2196/58335.

  PMID: 39298750 DERIVED

MeSH Terms

Conditions

Marijuana Abuse; Tobacco Use; Substance Withdrawal Syndrome; Substance-Related Disorders

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Behavior

Central Study Contacts

Cristina Martínez Martínez, PhD

CONTACT

932607335; cmartinez@iconcologia.net

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 6, 2022
• First Posted: August 23, 2022
• Study Start: July 1, 2023
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2025
• Last Updated: July 3, 2023

Record last verified: 2023-06

Data Sharing

• IPD Sharing: Will not share