NCT05277207

Brief Summary

There are significant barriers to tobacco cessation treatment for patients and providers in specialty care clinical settings. Specialty providers cite several barriers to delivering evidence-based tobacco cessation care, including insufficient time and lack of training. In addition, a large proportion of patients who begin tobacco cessation treatment do not quit. Use of healthcare technology (i.e., telehealth, electronic health record, and computerized treatment algorithms based on patient data) to improve patients' ability to quit tobacco use. The purpose of this study is to demonstrate the feasibility of a larger trial, and to evaluate the acceptability of the intervention design. Thirty participants will be assigned to receive either 1) a treatment that includes personalized counseling, tobacco cessation medications, and text messaging; or 2) referral to Department of Veterans Affairs' Quitline program plus SmokefreeVET, a text messaging program.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for phase_4

Timeline
Completed

Started May 2022

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 2, 2022

Completed
12 days until next milestone

First Posted

Study publicly available on registry

March 14, 2022

Completed
2 months until next milestone

Study Start

First participant enrolled

May 2, 2022

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 27, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 27, 2023

Completed
7 months until next milestone

Results Posted

Study results publicly available

May 7, 2024

Completed
Last Updated

May 7, 2024

Status Verified

April 1, 2024

Enrollment Period

1.4 years

First QC Date

March 2, 2022

Results QC Date

April 10, 2024

Last Update Submit

April 10, 2024

Conditions

Keywords

tobacco usesmoking

Outcome Measures

Primary Outcomes (1)

  • Number of Participants Who Report Post-treatment Satisfaction

    Post-treatment satisfaction will be measured at the 3-month follow-up. Satisfaction will be defined as a mean score greater than 3.5 on the satisfaction measure.

    Post-treatment 3-month follow-up visit (approximately three months after enrollment)

Secondary Outcomes (3)

  • Treatment Attendance

    Post-treatment, approximately eight weeks after baseline visit

  • Therapist-rated Treatment Acceptability in Active Treatment Group

    Post-treatment 3-month follow-up visit (approximately three months after enrollment)

  • Proportion of Participants Who Completed Treatment in the Active Treatment Group

    Post-treatment, approximately eight weeks after baseline visit

Study Arms (2)

MESH

EXPERIMENTAL

Participants assigned to this group will receive a treatment that includes personalized smoking cessation facilitation meetings with cognitive-behavioral therapy, personalized smoking cessation pharmacotherapy, and personalized text messaging.

Behavioral: Personalized Smoking Cessation Facilitation MeetingsDrug: Personalized Smoking Cessation PharmacotherapyBehavioral: Personalized Text Messaging Support

Best Practice Telehealth Group

ACTIVE COMPARATOR

Participants assigned to this group will be referred to Quit Vet (VA's quitline for stopping tobacco) and SmokefreeVET (a free text messaging program to help you quit), and will receive information about getting quit medications.

Behavioral: SmokefreeVETBehavioral: VA QuitlineOther: Education about pharmacotherapy

Interventions

Participants will participate in 5-7 meetings in which they will receive cognitive-behavioral therapy for tobacco cessation.

MESH

Participants may receive pharmacotherapy for smoking cessation based on VA Pharmacy Benefits Management Services guidelines. Medications may include nicotine-replacement therapy, varenicline, and/or bupropion.

MESH

If the participant has a working cell phone and is willing to receive text messages, supportive, personalized text messages will be sent to the participant starting after Session 1 and extending through 6 months post-quit using VA's Annie texting capability.

Also known as: Annie
MESH
SmokefreeVETBEHAVIORAL

Participants will receive a referral to SmokefreeVET, a text-messaging intervention designed to help veterans prepare for and attempt quitting smoking.

Best Practice Telehealth Group
VA QuitlineBEHAVIORAL

Participants will receive a referral to VA Quitline, which is a nationally available telehealth intervention that provides assistance to veterans who wish to quit tobacco use. Quitline includes five sessions of cognitive-behavioral treatment.

Best Practice Telehealth Group

Participants will receive a handout that provides them with information about pharmacotherapies for tobacco cessation.

Best Practice Telehealth Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Durham VA patient
  • willing to complete study procedures
  • appointment in Durham VA Infectious Disease (ID) Clinic or Durham VA Cardiology Section within the past 12 months
  • currently smoking 7 times per week (cigarettes, cigars, cigarillos, hookah, etc.) and/or using 1 can of smokeless tobacco per week

You may not qualify if:

  • participation in Aim 3 (already received the intervention)
  • current hospitalization (recent hospitalization is acceptable)
  • currently not using combustible or smokeless tobacco (vaping only)
  • acute risk for suicide documented in the medical record
  • or inability to complete study procedures

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Durham VA Medical Center, Durham, NC

Durham, North Carolina, 27705-3875, United States

Location

MeSH Terms

Conditions

Tobacco UseSmoking

Condition Hierarchy (Ancestors)

Behavior

Results Point of Contact

Title
Angela Kirby
Organization
Durham VA Health Care System

Study Officials

  • Sarah M. Wilson, PhD

    Durham VA Medical Center, Durham, NC

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
FED
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 2, 2022

First Posted

March 14, 2022

Study Start

May 2, 2022

Primary Completion

September 27, 2023

Study Completion

September 27, 2023

Last Updated

May 7, 2024

Results First Posted

May 7, 2024

Record last verified: 2024-04

Data Sharing

IPD Sharing
Will not share

De-identified data sets will be available upon written FOIA request. Final data sets will also be maintained locally until enterprise-level resources become available for broader long-term storage and access unless the relevant ORD or VA Program Office Funding Announcement states otherwise.

Locations