The Association Between Intestinal Perfusion and Prolonged Mechanical Ventilation in Patients After Cardiac Valve Surgery

NCT05500495 | Completed

• 1 other identifier: ZS-3088
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Background This study aimed to confirm that alterations in Doppler parameters of superior mesenteric artery(SMA) blood flow caused by intestinal hypoperfusion are associated with prolonged mechanical ventilation(PMV) in patients after cardiac valve surgery. Methods The patients' basic hemodynamics parameters, and the SMA blood flow parameters monitored by Doppler ultrasound were collected in the supine position at admission. The length of mechanical ventilation continued to be monitored. The SMA Doppler parameters were measured again when the patient was extubated. PMV was defined as MV≥96 hours.

Conditions

Patient After Cardiac Valve Surgery; Patient With Prolonged Mechanical Ventilation

Keywords

Pulsatility index of the superior mesenteric artery; Prolonged Mechanical Ventilation; cardiac valve surgery; intestinal perfusion

Outcome Measures

Primary Outcomes (1)

• hours of mechanical ventilation

  hours of mechanical ventilation

  within 30mins at ICU admission

Secondary Outcomes (1)

• ICU residence time

  within 30mins at ICU admission

Study Arms (2)

prolonged mechanical ventilation group

patients had 96 hours or more (PMV group).

Other: no intervention

control group

patients had less than 96 hours of mechanical ventilation (control group)

Other: no intervention

Interventions

no intervention OTHER

no intervention

control group; prolonged mechanical ventilation group

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The patient was enrolled in the 15-bed adult critical care unit in Adult General Hospital

You may qualify if:

• \) patients admitted to ICU immediately after cardiac valve surgery; 2) age 18-80 years; 3) sinus rhythm; 4) without active bleeding or pneumothorax, and 5) complete measurement data.

You may not qualify if:

• \) history of peripheral vascular disease, 2) patients with severe stenosis defined as SMA peak systolic velocity (SMA-PSV \>275 cm/s or SMA-PSV/abdominal aorta peak velocity of \>310, 3) hepatic dysfunction or liver cirrhosis, portal hypertension, 4) cancer or end-stage renal diseases, 5) poor quality of abdominal ultrasound images.

Sponsors & Collaborators

• Peking Union Medical College Hospital: lead

Study Sites (1)

Peking union medical college hospital

Beijing, Beijing Municipality, 100730, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 11, 2022
• First Posted: August 15, 2022
• Study Start: January 1, 2021
• Primary Completion: March 1, 2022
• Study Completion: March 1, 2022
• Last Updated: August 15, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)