Tobacco Use and Uptake of COVID-19 Vaccinations

NCT05479383 | Unknown

• 1 other identifier: THL/713/6.00.00/2021.2
• Study Type: observational
• Target: 42,935
• Locations: 1 country
• Sites: 1

Brief Summary

This is an observational study of participants in two general population health surveys (FinSote 2018 and 2020) who are followed up for their COVID-19 vaccinations or end of follow-up. The primary objective is to examine the association between tobacco use and COVID-19 vaccine uptake and between-dose spacing.

Conditions

COVID-19; Smoking; Tobacco Use; Vaccination Refusal

Keywords

Tobacco use; Smoking; COVID-19; SARS-CoV-2; Vaccinations; Cohort studies

Outcome Measures

Primary Outcomes (1)

• Vaccination uptake of at least two doses of a COVID-19 vaccine

  Proportion of participants with at least two doses of a COVID-19 vaccine

  Baseline until date of vaccination or May 31, 2022

Secondary Outcomes (4)

• Vaccination uptake of at least one dose of a COVID-19 vaccine

  Baseline until date of vaccination or May 31, 2022

• Vaccination uptake of complete COVID-19 vaccination scheme (two doses and a booster dose)

  Baseline until date of vaccination or May 31, 2022

• Spacing of first and second COVID-19 dose

  Baseline until date of vaccination or May 31, 2022

• Spacing of second dose and booster dose of the COVID-19 vaccine

  Baseline until date of vaccination or May 31, 2022

Study Arms (1)

Tobacco users

Tobacco users Never smokers (reference group) will be compared with former smokers, occasional smokers and daily smokers. Never snus users (reference group) will also compare with never users, former users and current users.

Other: Not applicable, this is an observational study

Interventions

Not applicable, this is an observational study OTHER

Not applicable, this is an observational study

Tobacco users

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Permanent residents in Finland aged 20 and over who participated in the FinSote surveys in 2018 and 2020. These are general population samples representative of the Finnish population. The sampling frame was the Population Register (in 2020 the Digital and Population Data Services Agency, created after the merge between the Population Register of Statistics Finland and local register offices), which includes all individuals residing permanently in Finland, including conscripts and people living in institutions.

You may qualify if:

• Permanent residents of Finland
• Registered in the Population Register at the moment of sampling
• Aged 20 and over
• Participated in the FinSote surveys in 2018 or 2020
• Provided consent for register linkage

You may not qualify if:

• Temporary residents in Finland or tourists
• Age less than 20 years old
• Did not participate in FinSote surveys in 2018, 2019 and 2020
• Did not provide consent for register linkage

Sponsors & Collaborators

• Finnish Institute for Health and Welfare: lead
• Karolinska Institutet: collaborator
• Norwegian Institute of Public Health: collaborator

Study Sites (1)

Finnish Institute for Health and Welfare

Helsinki, Uusimaa, 00271, Finland

Location

Related Publications (13)

• Simons D, Shahab L, Brown J, Perski O. The association of smoking status with SARS-CoV-2 infection, hospitalization and mortality from COVID-19: a living rapid evidence review with Bayesian meta-analyses (version 7). Addiction. 2021 Jun;116(6):1319-1368. doi: 10.1111/add.15276. Epub 2020 Nov 17.

  PMID: 33007104 BACKGROUND

• Jackson SE, Paul E, Brown J, Steptoe A, Fancourt D. Negative Vaccine Attitudes and Intentions to Vaccinate Against Covid-19 in Relation to Smoking Status: A Population Survey of UK Adults. Nicotine Tob Res. 2021 Aug 18;23(9):1623-1628. doi: 10.1093/ntr/ntab039.

  PMID: 33751125 BACKGROUND

• Krebs NM, D'Souza G, Bordner C, Allen SI, Hobkirk AL, Foulds J, Yingst JM. COVID-19 Vaccination Uptake and Hesitancy Among Current Tobacco Users. Tob Use Insights. 2021 Dec 20;14:1179173X211068027. doi: 10.1177/1179173X211068027. eCollection 2021.

  PMID: 34987300 BACKGROUND

• Ali M, Ahmed S, Bonna AS, Sarkar AS, Islam MA, Urmi TA, Proma TS. Parental coronavirus disease vaccine hesitancy for children in Bangladesh: a cross-sectional study. F1000Res. 2022 Jan 25;11:90. doi: 10.12688/f1000research.76181.2. eCollection 2022.

  PMID: 35211297 BACKGROUND

• Oruc MA, Ozturk O. Attitudes of health care professionals towards COVID-19 vaccine - a sequence from Turkey. Hum Vaccin Immunother. 2021 Oct 3;17(10):3377-3383. doi: 10.1080/21645515.2021.1928462. Epub 2021 Jun 18.

  PMID: 34142925 BACKGROUND

• Wu J, Li Q, Silver Tarimo C, Wang M, Gu J, Wei W, Ma M, Zhao L, Mu Z, Miao Y. COVID-19 Vaccine Hesitancy Among Chinese Population: A Large-Scale National Study. Front Immunol. 2021 Nov 29;12:781161. doi: 10.3389/fimmu.2021.781161. eCollection 2021.

  PMID: 34912346 BACKGROUND

• Luk TT, Zhao S, Wu Y, Wong JY, Wang MP, Lam TH. Prevalence and determinants of SARS-CoV-2 vaccine hesitancy in Hong Kong: A population-based survey. Vaccine. 2021 Jun 16;39(27):3602-3607. doi: 10.1016/j.vaccine.2021.05.036. Epub 2021 May 18.

  PMID: 34034950 BACKGROUND

• Wisniak A, Baysson H, Pullen N, Nehme M, Pennacchio F, Zaballa ME, Guessous I, Stringhini S; Specchio-COVID19 study group. COVID-19 vaccination acceptance in the canton of Geneva: a cross-sectional population-based study. Swiss Med Wkly. 2021 Dec 14;151:w30080. doi: 10.4414/smw.2021.w30080. eCollection 2021 Dec 6.

  PMID: 34908389 BACKGROUND

• Ishimaru T, Okawara M, Ando H, Hino A, Nagata T, Tateishi S, Tsuji M, Matsuda S, Fujino Y; CORoNaWork Project. Gender differences in the determinants of willingness to get the COVID-19 vaccine among the working-age population in Japan. Hum Vaccin Immunother. 2021 Nov 2;17(11):3975-3981. doi: 10.1080/21645515.2021.1947098. Epub 2021 Jul 2.

  PMID: 34213406 BACKGROUND

• Ko T, Dendle C, Woolley I, Morand E, Antony A. SARS-COV-2 vaccine acceptance in patients with rheumatic diseases: a cross-sectional study. Hum Vaccin Immunother. 2021 Nov 2;17(11):4048-4056. doi: 10.1080/21645515.2021.1958611. Epub 2021 Aug 6.

  PMID: 34357827 BACKGROUND

• Tan LF, Huak CY, Siow I, Tan AJ, Venugopalan PM, Premkumar A, Seetharaman SK, Tan BYQ. The road to achieving herd immunity: factors associated with Singapore residents' uptake and hesitancy of the COVID-19 vaccination. Expert Rev Vaccines. 2022 Apr;21(4):561-567. doi: 10.1080/14760584.2022.2021883. Epub 2022 Jan 11.

  PMID: 34937504 BACKGROUND

• Tiirinki H, Viita-Aho M, Tynkkynen LK, Sovala M, Jormanainen V, Keskimaki I. COVID-19 in Finland: Vaccination strategy as part of the wider governing of the pandemic. Health Policy Technol. 2022 Jun;11(2):100631. doi: 10.1016/j.hlpt.2022.100631. Epub 2022 Apr 14.

  PMID: 35437478 BACKGROUND

• Pena S, Zhou Z, Kestila L, Galanti MR, Shaaban AN, Caspersen IH, Magnus P, Geraldo P, Rojas-Saunero P, Parikka S, Nohynek H, Karvonen S. Tobacco Use and Uptake of COVID-19 Vaccinations in Finland: A Population-Based Study. Nicotine Tob Res. 2024 Oct 22;26(11):1553-1562. doi: 10.1093/ntr/ntad234.

  PMID: 38196092 DERIVED

Related Links

• Description of the Tobrisk-CoV project

MeSH Terms

Conditions

COVID-19; Smoking; Tobacco Use; Vaccination Refusal

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Behavior; Treatment Refusal; Treatment Adherence and Compliance; Health Behavior

Study Officials

• Sakari Karvonen, PhD

  Finnish Institute for Health and Welfare

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 28, 2022
• First Posted: July 29, 2022
• Study Start: October 2, 2017
• Primary Completion: June 1, 2023
• Study Completion: June 1, 2023
• Last Updated: May 6, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)