Socioeconomic Differences in Alcohol Harm in Finland in a Nationwide Cohort Study

NCT05865847 | Unknown

• 1 other identifier: KKO-Inv 4-Johto-VPT-Terveysind
• Study Type: observational
• Target: 3,950,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a nationwide cohort study of Finnish adults aged 25 and older, who are followed up for the incidence of an alcohol-attributable hospitalization or death. The primary objective is to examine the relative and absolute socioeconomic differences in cause-specific alcohol-attributable hospital admissions and deaths.

Conditions

Alcohol-Related Disorders

Outcome Measures

Primary Outcomes (18)

• Alcohol intoxication - Hospitalization

  Incidence of alcohol intoxication hospitalization (ICD-10 F10.0-1)

  January 1, 2016 to February 28, 2020

• Alcohol intoxication - Death

  Death due to alcohol intoxication (ICD-10 F10.0-1)

  January 1, 2016 to February 28, 2020

• Alcohol dependence - Hospitalization

  Incidence of hospitalization due to alcohol dependence (F10.2)

  January 1, 2016 to February 28, 2020

• Alcohol dependence - Death

  Death due to alcohol dependence (F10.2)

  January 1, 2016 to February 28, 2020

• Psycho-organic syndrome caused by alcohol - Hospitalization

  Incidence of hospitalization due to psycho-organic syndrome caused by alcohol (F10.3-9)

  January 1, 2016 to February 28, 2020

• Psycho-organic syndrome caused by alcohol - Death

  Death due to psycho-organic syndrome caused by alcohol (F10.3-9)

  January 1, 2016 to February 28, 2020

• Alcoholic liver disease - Hospitalization

  Incidence of hospitalization due to alcoholic liver disease(K70)

  January 1, 2016 to February 28, 2020

• Alcoholic liver disease - Death

  Death due to alcoholic liver disease(K70)

  January 1, 2016 to February 28, 2020

• Pancreatic diseases caused by alcohol - Hospitalization

  Incidence of hospitalization due to pancreatic diseases caused by alcohol (K85.2, K86.0)

  January 1, 2016 to February 28, 2020

• Pancreatic diseases caused by alcohol - Death

  Death due to pancreatic diseases caused by alcohol (K85.2, K86.0)

  January 1, 2016 to February 28, 2020

• Gastritis caused by alcohol - Hospitalization

  Incidence of hospitalization due to gastritis caused by alcohol (K29.2)

  January 1, 2016 to February 28, 2020

• Gastritis caused by alcohol - Death

  Death due to gastritis caused by alcohol (K29.2)

  January 1, 2016 to February 28, 2020

• Alcoholic cardiomyopathy - Hospitalization

  Incidence of hospitalization due to alcoholic cardiomyopathy (I42.6)

  January 1, 2016 to February 28, 2020

• Alcoholic cardiomyopathy - Death

  Death due to alcoholic cardiomyopathy (I42.6)

  January 1, 2016 to February 28, 2020

• Nervous system disorders caused by alcohol - Hospitalization

  Incidence of hospitalization due to degeneration of the nervous system due to alcohol, epileptic seizures related to alcohol, alcoholic polyneuropathy, alcoholic myopathy (G312, G4051, G621, G721)

  January 1, 2016 to February 28, 2020

• Nervous system disorders caused by alcohol - Death

  Death due to degeneration of the nervous system due to alcohol, epileptic seizures related to alcohol, alcoholic polyneuropathy, alcoholic myopathy (G312, G4051, G621, G721)

  January 1, 2016 to February 28, 2020

• Alcohol poisoning - Hospitalization

  Incidence of hospitalization due to alcohol poisoning (T51, X45)

  January 1, 2016 to February 28, 2020

• Alcohol poisoning - Death

  Death due to alcohol poisoning (T51, X45)

  January 1, 2016 to February 28, 2020

Study Arms (1)

Lowest income groups

Deciles of equivalized net household income. The method compares the whole socioeconomic distribution.

Other: Not applicable, this is an observational study

Interventions

Not applicable, this is an observational study OTHER

Not applicable, this is an observational study

Lowest income groups

Eligibility Criteria

• Age: 25 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All permanent residents in Finland older than 25 years old and without an alcohol-attributable hospital admission during the past three years

You may qualify if:

• Permanent residents (defined by Statistics Finland as those Finnish and foreign nationals who have a legal domicile in Finland and intend to stay (or have stayed) for at least one year) alive in Finland by December 31, 2015
• Age 25 years or older by January 1, 2016
• Not having an alcohol-attributable hospitalization during the past three years ((January 2013-December 2015

You may not qualify if:

• Temporary residents, including foreign nationals living in Finland for less than a year, asylum seekers who have not been granted a legal domicile, temporary migrant workers and Finnish nationals living temporarily abroad by December 31, 2015

Sponsors & Collaborators

• Finnish Institute for Health and Welfare: lead
• Social Insurance Institution, Finland: collaborator

Related Publications (14)

• GBD 2016 Alcohol Collaborators. Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2018 Sep 22;392(10152):1015-1035. doi: 10.1016/S0140-6736(18)31310-2. Epub 2018 Aug 23.

  PMID: 30146330 BACKGROUND

• Manthey J, Hassan SA, Carr S, Kilian C, Kuitunen-Paul S, Rehm J. What are the Economic Costs to Society Attributable to Alcohol Use? A Systematic Review and Modelling Study. Pharmacoeconomics. 2021 Jul;39(7):809-822. doi: 10.1007/s40273-021-01031-8. Epub 2021 May 10.

  PMID: 33970445 BACKGROUND

• Room R, Ferris J, Laslett AM, Livingston M, Mugavin J, Wilkinson C. The drinker's effect on the social environment: a conceptual framework for studying alcohol's harm to others. Int J Environ Res Public Health. 2010 Apr;7(4):1855-71. doi: 10.3390/ijerph7041855. Epub 2010 Apr 21.

  PMID: 20617064 BACKGROUND

• Probst C, Lange S, Kilian C, Saul C, Rehm J. The dose-response relationship between socioeconomic deprivation and alcohol-attributable mortality risk-a systematic review and meta-analysis. BMC Med. 2021 Nov 5;19(1):268. doi: 10.1186/s12916-021-02132-z.

  PMID: 34736475 BACKGROUND

• Probst C, Kilian C, Sanchez S, Lange S, Rehm J. The role of alcohol use and drinking patterns in socioeconomic inequalities in mortality: a systematic review. Lancet Public Health. 2020 Jun;5(6):e324-e332. doi: 10.1016/S2468-2667(20)30052-9.

  PMID: 32504585 BACKGROUND

• Syden L, Sidorchuk A, Makela P, Landberg J. The contribution of alcohol use and other behavioural, material and social factors to socio-economic differences in alcohol-related disorders in a Swedish cohort. Addiction. 2017 Nov;112(11):1920-1930. doi: 10.1111/add.13889. Epub 2017 Jul 17.

  PMID: 28556302 BACKGROUND

• Makela P, Paljarvi T. Do consequences of a given pattern of drinking vary by socioeconomic status? A mortality and hospitalisation follow-up for alcohol-related causes of the Finnish Drinking Habits Surveys. J Epidemiol Community Health. 2008 Aug;62(8):728-33. doi: 10.1136/jech.2007.065672.

  PMID: 18621959 BACKGROUND

• Pena S, Makela P, Laatikainen T, Harkanen T, Mannisto S, Heliovaara M, Koskinen S. Joint effects of alcohol use, smoking and body mass index as an explanation for the alcohol harm paradox: causal mediation analysis of eight cohort studies. Addiction. 2021 Aug;116(8):2220-2230. doi: 10.1111/add.15395. Epub 2021 Jan 28.

  PMID: 33404149 BACKGROUND

• Katikireddi SV, Whitley E, Lewsey J, Gray L, Leyland AH. Socioeconomic status as an effect modifier of alcohol consumption and harm: analysis of linked cohort data. Lancet Public Health. 2017 May 10;2(6):e267-e276. doi: 10.1016/S2468-2667(17)30078-6. eCollection 2017 Jun.

  PMID: 28626829 BACKGROUND

• Makela P. Alcohol-related mortality as a function of socio-economic status. Addiction. 1999 Jun;94(6):867-86. doi: 10.1046/j.1360-0443.1999.94686710.x.

  PMID: 10665076 BACKGROUND

• Pena S, Makela P, Harkanen T, Heliovaara M, Gunnar T, Mannisto S, Laatikainen T, Vartiainen E, Koskinen S. Measurement error as an explanation for the alcohol harm paradox: analysis of eight cohort studies. Int J Epidemiol. 2021 Jan 23;49(6):1836-1846. doi: 10.1093/ije/dyaa113.

  PMID: 32995840 BACKGROUND

• Sadler S, Angus C, Gavens L, Gillespie D, Holmes J, Hamilton J, Brennan A, Meier P. Understanding the alcohol harm paradox: an analysis of sex- and condition-specific hospital admissions by socio-economic group for alcohol-associated conditions in England. Addiction. 2017 May;112(5):808-817. doi: 10.1111/add.13726. Epub 2017 Feb 6.

  PMID: 27981670 BACKGROUND

• Mackenbach JP, Kulhanova I, Bopp M, Borrell C, Deboosere P, Kovacs K, Looman CW, Leinsalu M, Makela P, Martikainen P, Menvielle G, Rodriguez-Sanz M, Rychtarikova J, de Gelder R. Inequalities in Alcohol-Related Mortality in 17 European Countries: A Retrospective Analysis of Mortality Registers. PLoS Med. 2015 Dec 1;12(12):e1001909. doi: 10.1371/journal.pmed.1001909. eCollection 2015 Dec.

  PMID: 26625134 BACKGROUND

• Mackenbach JP. Should we aim to reduce relative or absolute inequalities in mortality? Eur J Public Health. 2015 Apr;25(2):185. doi: 10.1093/eurpub/cku217. No abstract available.

  PMID: 25818489 BACKGROUND

MeSH Terms

Conditions

Alcohol-Related Disorders

Condition Hierarchy (Ancestors)

Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Sebastián Peña, MD, PhD

  Finnish Institute for Health and Welfare

  PRINCIPAL INVESTIGATOR

• Sonja Lumme, PhD

  Finnish Institute for Health and Welfare

  STUDY CHAIR

• Päivikki Koponen, PhD

  Finnish Institute for Health and Welfare

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 3, 2023
• First Posted: May 19, 2023
• Study Start: January 1, 2015
• Primary Completion: February 28, 2020
• Study Completion: September 30, 2023
• Last Updated: May 19, 2023

Record last verified: 2023-05

Data Sharing

• IPD Sharing: Will not share