The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults
1 other identifier
interventional
40
1 country
1
Brief Summary
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jul 2022
Typical duration for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 9, 2022
CompletedFirst Posted
Study publicly available on registry
July 21, 2022
CompletedStudy Start
First participant enrolled
July 25, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2025
CompletedApril 10, 2024
April 1, 2024
2.5 years
May 9, 2022
April 9, 2024
Conditions
Outcome Measures
Primary Outcomes (6)
Continuous glucose monitoring
3 days before removal of exercise
Continuous glucose monitoring
After removal of exercise for 5 days
Continuous glucose monitoring
After return to exercise for 3 days
Flow mediated dilation
This measure assess blood vessel health non-invasively
3 days before removal of exercise
Flow mediated dilation (vascular health)
This measure assess blood vessel health non-invasively
After removal of exercise for 5 days
Flow mediated dilation (vascular health)
This measure assess blood vessel health non-invasively
After return to exercise for 3 days
Study Arms (2)
Metabolic
EXPERIMENTALMetabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX/REX phases first. The EX and NOEX/REX phases will be separated by at least 1 week
Vascular
EXPERIMENTALVascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX).
Interventions
Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.
Eligibility Criteria
You may qualify if:
- years and older, 18-40 years old
- Healthy, physically active, performing at least 90 min/week of physical activity
- Free of physical limitations that may interfere with alterations in daily physical activity levels
You may not qualify if:
- Physician diagnosed HIV, hepatitis, or tuberculosis.
- Body weight change of greater than 5% within the previous 2 months
- Smoking within the previous 2 months.
- Taking medications that alter blood glucose levels
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Old Dominion University
Norfolk, Virginia, 23529, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
May 9, 2022
First Posted
July 21, 2022
Study Start
July 25, 2022
Primary Completion
January 30, 2025
Study Completion
April 1, 2025
Last Updated
April 10, 2024
Record last verified: 2024-04