Physical Inactivity Impacts on Blood Vessel Health and Glucose Levels in an Aging Population

NCT04812392 | Completed FDA Device

• 1 other identifier: ERP-2021-12576
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Physical inactivity is known to increase post meal blood sugar levels in young, active populations. However, how quickly this may occur in active, older adults is not clear. Further, the relationship between blood vessel health and blood sugar disturbances which occur to acute physical inactivity is not clear. It is unknown if impairments in blood vessel function precede increases in blood sugar levels that occurs with inactivity in an aging population. This study aims to determine if short term reductions in physical activity impair blood vessel health and blood glucose control to a greater extent in an aging population compared to a young population. The investigators hypothesize that 3 days of reduced physical activity will result in impaired blood vessel function and glycemic control in an aged population.

Conditions

Aging; Cardiovascular Diseases; Glucose Intolerance

Keywords

diabetes; physical inactivity; vascular function

Outcome Measures

Primary Outcomes (1)

• Change in glycemic control during a reduced physical activity state

  The change in blood glucose levels measured following consumption of a meal will be assessed before inactivity and following 3 days of inactivity.

  The change of blood glucose values from pre-inactivity and following 3 days of inactivity

Study Arms (1)

Acute Physical Inactivity

EXPERIMENTAL

Subjects will undergo 3 days of reduced physical activity.

Device: Continuous Glucose Monitoring System

Interventions

Continuous Glucose Monitoring System DEVICE

Subjects will wear a continuous glucose monitoring system for 3 days during the 3 day reduced physical activity phase.

Acute Physical Inactivity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years and older, 18-40 years old
• Healthy, physically active, performing at least 90 min/week of physical activity
• Free of physical limitations that may interfere with alterations in daily physical activity levels

You may not qualify if:

• Physician diagnosed metabolic disease, HIV, hepatitis, or tuberculosis.
• Body weight change of greater than 5% within the previous 2 months
• Smoking within the previous 2 months.
• Taking medications that alter blood glucose levels

Sponsors & Collaborators

• Leryn Reynolds: lead

Study Sites (1)

Old Dominion University

Norfolk, Virginia, 23508, United States

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Glucose Intolerance; Diabetes Mellitus; Sedentary Behavior

Interventions

Continuous Glucose Monitoring

Condition Hierarchy (Ancestors)

Hyperglycemia; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Blood Chemical Analysis; Clinical Chemistry Tests; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Endocrine; Monitoring, Physiologic; Investigative Techniques

Study Officials

• Leryn Reynolds, Ph.D.

  Old Dominion University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: March 16, 2021
• First Posted: March 23, 2021
• Study Start: April 1, 2021
• Primary Completion: January 30, 2022
• Study Completion: January 30, 2022
• Last Updated: March 4, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)