Study by Electroencephalography of the Link Between the Lack of Self-compassion and the Disorder of Empathy in Schizophrenia

NCT05464563 | Completed

• 1 other identifier: 2021-A01913-38
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This research project focuses on a fundamental element of the psychopathology of schizophrenia, that is to say, the disorders of self-awareness and on the functional alterations associated with it, that is to say, self-compassion deficit and empathy disorder. It will be a question of better understanding the neuro-functional mechanisms which underlie the lack of self-compassion and the disorder of empathy in schizophrenia, the relationship that these disorders maintain between them but also the relationship that they maintain with the general psychopathology of schizophrenia and, in particular, with the abnormalities of the self. In other words, the overall framework of this project is that of the link between the psychopathology of schizophrenia and the functional impairment associated with it. Its specific field of application is that of the link between self-awareness disorders, self-compassion deficit and empathy disorder. For this, this project proposes a methodological approach combining the recording of intrinsic and extrinsic brain activity using high-density electroencephalography (EEG).

Conditions

Schizophrenia; Schizoaffective Disorder

Outcome Measures

Primary Outcomes (1)

• Correlation between the temporal parameters of the EEG microstates C, D, E and F (duration, contribution, occurrence) and the inter-subject correlation index during the practice of self-compassion and the practice of empathy.

  Correlation between the temporal parameters of the EEG microstates C, D, E and F (duration, contribution, occurrence) and the inter-subject correlation index during the practice of self-compassion and the practice of empathy.

  through study completion, an average of 36 months.

Study Arms (2)

Patient group

EXPERIMENTAL

Patients have electroencephalogram records during : * a phase of rest; * a task of self-compassion * a task of empathy.

Device: Electroencephalogram

Control group

EXPERIMENTAL

Healthy volunteers have electroencephalogram records during : * a phase of rest; * a task of self-compassion * a task of empathy.

Device: Electroencephalogram

Interventions

Electroencephalogram DEVICE

An electroencephalogram is recorded during a task of rest then self-compassion and then empathy.

Control group; Patient group

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• patients with a schizophrenic or schizoaffective disorder according to the DSM-5 criteria (axis 1), with no other pathology of axis 1, except addiction to tobacco
• patients stabilized for at least 3 months for their psychotic disorders
• patients with disease duration \> 2 years but \< 20 years
• patients whose treatment has not been changed or modified in the previous month
• patients on stable treatments who should not change treatment during the study (good compliance, good tolerance)
• patients who do not benefit from a neuromodulation protocol for their symptoms (rTMS, TDCS)
• patients who do not benefit from a cognitive remediation program
• patients between the ages of 18 and 60
• men and women
• patients with normal or corrected vision
• patients without mental impairment
• patients without neurological impairment (epilepsy, encephalopathy, head trauma)
• patients with a sufficient command of French
• patients free or under protective measures
• patients benefiting from coverage by a social security scheme or benefiting from it through a third party

You may not qualify if:

• patients with an axis 1 pathology other than a schizophrenic or schizoaffective disorder (in particular, psychic trauma revealed by MINI and symptoms of PTSD (current as lifetime))
• patients with an addiction to alcohol or other toxic substances, except tobacco
• patients with suicidal intentionality
• patients not stabilized for their psychotic disorders and with regard to their antipsychotic treatments
• patients receiving antiepileptic treatment with mood-regulating, antidepressant and anxiolytic properties
• patients receiving benzodiazepine treatment that they could not stop 72 hours before the EEG
• patients with disease duration \< 2 years or \> 20 years
• patients with an IQ \< 70
• patients benefiting from a neuromodulation protocol (rTMS, TDCS)
• patients benefiting from a cognitive remediation program
• patients with a PANSS \> or = 5 for items G8 (hostility) and P7 (non-cooperation)
• patients aged \< 18 years or \> 60 years
• patients with mental impairment
• patients with neurological impairment (epilepsy, encephalopathy, head trauma)
• patients with documented neurological pathology or medical condition that may explain the psychotic manifestations

Sponsors & Collaborators

• Centre Hospitalier Henri Laborit: lead

Study Sites (1)

Centre Hospitalier Henri Laborit

Poitiers, 86000, France

Location

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders

Interventions

Electroencephalography

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2022
• First Posted: July 19, 2022
• Study Start: March 22, 2022
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: August 20, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)