Toward a Real-time Access to Sleepers' Mental Content

NCT05452733 | Terminated

• 1 other identifier: APHP220764
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Sleep is crucial for global cognitive functioning, but its exact functions and mechanisms are still poorly understood. Cognitive studies of sleep typically rely on linking electrophysiological changes measured during sleep with behavioral and neural changes collected in tasks performed during wakefulness. What concomitantly happens in the mind of sleeping subjects is often ignored, certainly because it is virtually inaccessible. Yet, major advances in the understanding of human behaviors have resulted from an integrated approach that combines both neural and cognitive measures of their ongoing mental processes. The goal of this study is to provide real-time measures of the cognitive processes occurring within sleep. To prompt real-time access to the sleeping mind, investigators will use auditory stimulation in people with unique sleep peculiarities: sleepwalkers whose overt behaviours may enable to objectively visualize ongoing cognitive processes during non-REM (NREM) sleep.

Conditions

Memory Reactivation; Memory Consolidation; Sleepwalking

Keywords

sleepwalking; sleep; memory consolidation; reactivation; dream; targeted memory reactivation

Outcome Measures

Primary Outcomes (1)

• Behavioral reaction

  number of behavioral reactivations of the motor sequence following the auditory cues during sleep

  2 days

Secondary Outcomes (3)

• Evaluation of targeted memory reactivation (TMR) success in sleepwalkers by movements test

  2 days

• Quantification of movements exhibited during sleep

  2 days

• Determination of the link between dream and sensory cues

  2 days

Study Arms (2)

Sleepwalking patient

EXPERIMENTAL

Behavioral: differences of behavior between sleepwalking and non sleepwalking patient

Non sleepwalking patient

ACTIVE COMPARATOR

Behavioral: differences of behavior between sleepwalking and non sleepwalking patient

Interventions

differences of behavior between sleepwalking and non sleepwalking patient BEHAVIORAL

movement registry done by camera when low intensity sound are send to patient during sleep.

Non sleepwalking patient; Sleepwalking patient

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18-35 y.o
• Written consent
• Affiliated to social security
• Sleepwalking (group patients only)

You may not qualify if:

• Psychiatric or neurologic disorder
• Sleep disorder except sleepwalking for the patient group
• Surdity
• Pain or physical disability affecting the upper limbs
• Consumption of drugs altering sleep structure
• Subjects under legal protection

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• Institut National de la Santé Et de la Recherche Médicale, France: collaborator

Study Sites (1)

Service des Pathologies du Sommeil, Hôpital Pitié-Salpétrière

Paris, Paris, 75013, France

Location

MeSH Terms

Conditions

Somnambulism

Condition Hierarchy (Ancestors)

Sleep Arousal Disorders; Parasomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Study Officials

• Isabelle Arnulf, MD PhD

  APHP

  PRINCIPAL INVESTIGATOR

• Delphine Oudiette, PhD

  Institut National de la Santé Et de la Recherche Médicale, France

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 17, 2022
• First Posted: July 11, 2022
• Study Start: March 31, 2023
• Primary Completion: August 29, 2025
• Study Completion: August 29, 2025
• Last Updated: January 12, 2026

Record last verified: 2026-01

Locations

FR (1)