Functional Imagery of Sleepwalking

NCT02844231 | Completed

• 1 other identifier: UF 8585
• Study Type: interventional
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

Sleepwalking (also called somnambulism) is a disorder in which only SWS is disrupted. This NREM parasomnia is characterized by inappropriate motor behaviors, usually initiated during arousal from SWS, that induce psychological distress and alter quality of life, leading to fatigue, excessive daytime sleepiness, and objectively impaired vigilance in the morning. The pathophysiology of sleepwalking remains poorly understood. Sleepwalkers had difficulty maintaining stable, consolidated sleep and experienced more arousals and microarousals, specifically from SWS, leading to increased NREM instability, especially during the first sleep cycles. The brain is partially awake, resulting in behavioral manifestations, and partially in NREM sleep, resulting in no conscious awareness of actions. A Single Photonic Emission Computed Tomography (SPECT) study of one sleepwalking episode found increased activation in the posterior cingulate cortex and cerebellum, with deactivation in the frontoparietal associative cortices. Data from intracerebral EEGs during confusional arousals confirmed both local arousal of the motor and cingulate cortices and increased delta activity in the frontoparietal associative cortices. The investigators thus proposed a controlled study of SPECT imagery in 24 sleepwalkers (12 SPECT during a SW episode and 12 SPECT during slow wave sleep and 24 during wakefulness) and 12 controls (during slow wave sleep and wakefulness). SW episodes will be elicited by sleep deprivation condition associated with forced arousal (auditory stimulus). The comparative analyses of SPECT acquisitions between different states (wakefulness, slow wave sleep and SW) and populations (sleepwalkers versus controls) will provide new insights about the complex pathophysiology of SW episodes.

Conditions

Sleepwalking

Outcome Measures

Primary Outcomes (1)

• Brain metabolism measurement with brain scintigraphy

  Day 0

Secondary Outcomes (1)

• Cortical excitability measurement with transcranial magnetic stimulation

  Day 0

Study Arms (3)

Sleepwalker, SW episode

OTHER

Sleepwalker patients undergo single-photon emission computed tomography during a sleepwalking episode.

Other: Single-photon emission computed tomography

Sleepwalkers, slow wave sleep

OTHER

Sleepwalker patients undergo single-photon emission computed tomography during slow-wave sleep.

Other: Single-photon emission computed tomography

Control group

OTHER

Control subjects undergo single-photon emission computed tomography during slow-wave sleep.

Other: Single-photon emission computed tomography

Interventions

Single-photon emission computed tomography OTHER

Control group; Sleepwalker, SW episode; Sleepwalkers, slow wave sleep

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Subject diagnosed with NREM parasomnia according the international classification of sleep disorders
• More than one episode per week
• More than one hypersynchronous delta wave arousal recorded on polysomnographic assessment
• Affiliated to social security
• Age between 18 years-old and 39 years-old

You may not qualify if:

• Patient with obstructive sleep apnea Syndrome, restless legs syndrome, nocturnal epilepsy and unstable psychiatric disease.
• CONTROL GROUP
• Affiliated to social security
• Age between 18 years-old and 39 years-old
• Subject with following medical history : NREM parasomnia, neurologic or psychiatric disorder, obstructive sleep apnea syndrome, restless legs syndrome, nocturnal epilepsy.

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

University Hospital of Montpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Somnambulism

Condition Hierarchy (Ancestors)

Sleep Arousal Disorders; Parasomnias; Sleep Wake Disorders; Nervous System Diseases; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 18, 2016
• First Posted: July 26, 2016
• Study Start: April 1, 2010
• Primary Completion: June 6, 2016
• Study Completion: December 31, 2017
• Last Updated: May 29, 2024

Record last verified: 2024-05

Locations

FR (1)