NCT05442593

Brief Summary

Plyometric training comprises one of the most widely used training methods in both individual and team sports, and is widely used by coaches as one of the main training in both adults, and children. Plyometric training highly includes the component of eccentric contraction. However, eccentric muscle action, especially when unaccustomed, can lead to exercise-induced muscle damage (EIMD), which is accompanied by increased delayed onset of muscle soreness (DOMS), inflammatory responses, increased levels of muscle proteins into the circulation, oxidative stress, and reduction of muscle function and performance the following days. Although plyometric training is widely used in children and may lead to EIMD, there is limited data regarding the acute effects of plyometric exercise training in children. Additionally, the effect of the biological maturation status of children on EIMD after acute plyometric exercise training has not been investigated. The aim of this study is to examine the effect of biological maturation on EIMD after acute plyometric exercise training in children.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2022

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 23, 2022

Completed
4 days until next milestone

Study Start

First participant enrolled

June 27, 2022

Completed
8 days until next milestone

First Posted

Study publicly available on registry

July 5, 2022

Completed
25 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 30, 2022

Completed
Last Updated

November 4, 2022

Status Verified

November 1, 2022

Enrollment Period

1 month

First QC Date

June 23, 2022

Last Update Submit

November 3, 2022

Conditions

Keywords

childrenplyometric exercisemuscle damagemuscle performanceneuromuscular fatigue

Outcome Measures

Primary Outcomes (11)

  • Changes in Creatine kinase

    CK will be measured in plasma using a Clinical Chemistry Analyzer with commercially available kits.

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in blood lactate

    Lactate will be measured in capillary blood with a hand-portable analyzer.

    Baseline (pre), 4 minutes post-plyometric training

  • Changes in DOMS

    DOMS of knee extensors and knee flexors of both lower extremities will be measured during palpation of the muscle belly and the distal region after performing three repetitions of a full squat and each participant will rate perceived soreness on a scale ranging from 1 (no soreness) to 10 (very sore).

    Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours postplyometric training

  • Changes in 10m sprint time

    10m sprint time will be measured using light cells Chronojump system

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in 30m sprint time

    30m sprint time will be measured using light cells Chronojump system

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in squat jump

    Squat jump height will be measured using a Chronojump contact platform

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in counermovement jump

    Counermovement jump height will be measured using a Chronojump contact platform

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in concentric peak torque

    Concentric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in eccentric peak torque

    Eccentric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer

    Baseline (pre), 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in isometric peak torque

    Isometric peak torque of knee extensors and knee flexors will be measured on an isokinetic dynamometer

    Baseline (pre), post-, 24 hours post-, 48 hours post-, 72 hours post-plyometric training

  • Changes in maximal voluntary isometric contraction (MVIC)

    MVIC of knee extensors will be measured on an isokinetic dynamometer

    Baseline (pre), post-, 1 hour post-, 2 hours post-, 3 hours post-plyometric training

Secondary Outcomes (10)

  • Biological maturation stage

    Baseline

  • Testosterone levels

    Baseline

  • Age from Peak Height Velocity (APHV)

    Baseline

  • Body weight

    Baseline

  • Body height

    Baseline

  • +5 more secondary outcomes

Study Arms (2)

Pre-adolescents

EXPERIMENTAL

Acute plyometric training

Other: Plyometric training

Adolescents

EXPERIMENTAL

Acute plyometric training

Other: Plyometric training

Interventions

Participants will perform: 8 sets of 10 maximal countermovement jumps

AdolescentsPre-adolescents

Eligibility Criteria

Age8 Years - 15 Years
Sexmale
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Normal BMI
  • No history of growth irregularities
  • No musculoskeletal injuries for at least six months prior to the study
  • No use of drugs or ergogenic supplements for at least one month prior to the study
  • No participation at exercise with eccentric component for at least three days prior to the study
  • No energy drinks consumption before each experimental trial

You may not qualify if:

  • Abnormal BMI
  • History of growth irregularities
  • Musculoskeletal injuries in the last six months prior to the study
  • Use of drugs or ergogenic supplements in the last month prior to the study
  • Participation at exercise with eccentric component in the last three days prior to the study
  • Energy drinks consumption before each experimental trial

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Physical Education and Sport Science, Uninersity of Thessaly

Trikala, Thessaly, 42100, Greece

Location

Related Publications (3)

  • Marginson V, Rowlands AV, Gleeson NP, Eston RG. Comparison of the symptoms of exercise-induced muscle damage after an initial and repeated bout of plyometric exercise in men and boys. J Appl Physiol (1985). 2005 Sep;99(3):1174-81. doi: 10.1152/japplphysiol.01193.2004. Epub 2005 Apr 7.

    PMID: 15817716BACKGROUND
  • Deli CK, Fatouros IG, Paschalis V, Georgakouli K, Zalavras A, Avloniti A, Koutedakis Y, Jamurtas AZ. A Comparison of Exercise-Induced Muscle Damage Following Maximal Eccentric Contractions in Men and Boys. Pediatr Exerc Sci. 2017 Aug;29(3):316-325. doi: 10.1123/pes.2016-0185. Epub 2017 Feb 6.

    PMID: 28165870BACKGROUND
  • Asadi A, Ramirez-Campillo R, Arazi H, Saez de Villarreal E. The effects of maturation on jumping ability and sprint adaptations to plyometric training in youth soccer players. J Sports Sci. 2018 Nov;36(21):2405-2411. doi: 10.1080/02640414.2018.1459151. Epub 2018 Apr 3.

    PMID: 29611771BACKGROUND

MeSH Terms

Interventions

Plyometric Exercise

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Chariklia K Deli, PhD

    University of Thessaly

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
SCREENING
Intervention Model
PARALLEL
Model Details: Participants will be assigned to different groups according to their biological maturation and they will perform the same acute plyometric exercise
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

June 23, 2022

First Posted

July 5, 2022

Study Start

June 27, 2022

Primary Completion

July 30, 2022

Study Completion

July 30, 2022

Last Updated

November 4, 2022

Record last verified: 2022-11

Locations