Epidemiology and Clinical Characteristics of Emerging and Re-emerging Infectious Diseases With Epidemic Potential in Mali

NCT05441800 | Unknown

• 1 other identifier: UCRC-001
• Study Type: observational
• Target: 400
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective observational study to include participants with a spectrum of emerging or unknown pathogens with the objective to determine etiology and clinical characteristics of those diseases.

Conditions

Febrile Illness

Keywords

Unknown febrile; emerging or; re-emerging infectious disease

Outcome Measures

Primary Outcomes (1)

• Identify the etiologies and immediate outcomes of emerging and re-emerging diseases in Mali.

  To identify the etiologies (e.g. lassa fever, measles, covid-19, zika, Ebola virus disease) of unexplained febrile illnesses in adults and children in Mali measured by the proportion of cases identified who are children, or who are adults.

  In 3 years

Interventions

Observational Study OTHER

observational study to include participants with a spectrum of emerging or unknown pathogens with the objective to determine etiology and clinical characteristics of those diseases

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Subjects enrolled in this study will be identified by the National Epidemiological Monitoring Committee, the Department of Infectious and Tropical Diseases, or other services of the level-3 hospitals in the context of public health emergency or epidemic. Participants will be suspected of having a febrile illness due to an infectious pathogen that has not been formally identified by existing diagnostic strategies or standard of care testing.

You may not qualify if:

• \- Participants may be excluded from enrolling in the study if they have any known medical disorders or other circumstances which, in the opinion of the investigator, might make participation unsafe or difficult (e.g. inability to obtain necessary samples, mental illness).

Sponsors & Collaborators

• University Clinical Research Center, Mali: lead
• National Institute of Allergy and Infectious Diseases (NIAID): collaborator

Study Sites (1)

University Clinical Research Center (UCRC) / USTTB

Bamako, Mali

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples, Other samples

MeSH Terms

Conditions

Communicable Diseases, Emerging

Interventions

Observation

Condition Hierarchy (Ancestors)

Communicable Diseases; Infections; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Sounkalo DAO, MD

  University of Science, Techniques and Technologies of Bamako, Mali

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sounkalo DAO, MD

CONTACT

+223 72 27 49 71; sounkalod@icermali.org

Oumar GUINDO, PharmD, MPH

CONTACT

+22376410338; oumarmguindo@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Month
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 7, 2022
• First Posted: July 1, 2022
• Study Start: June 18, 2020
• Primary Completion: June 18, 2023
• Study Completion: June 18, 2023
• Last Updated: July 1, 2022

Record last verified: 2022-06

Locations

MA (1)