The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing

NCT05441007 | Completed

• 1 other identifier: CTU HYPERCO
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Conditions

Hypoxia; Hypercapnia; Cardiac Output, High

Keywords

Cardiac Output; Perfusion index; Pulse oximetry

Outcome Measures

Primary Outcomes (2)

• Changes in Cardiac output due to the induced hypoxia and hypercapnia

  Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change

  1 hour

• Changes in Perfusion index due to the induced hypoxia and hypercapnia

  Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change

  1 hour

Study Arms (3)

Hypoxic

EXPERIMENTAL

Participants inhale ambient air, the hypoxic gas mixture, and ambient air.

Other: Hypoxic

Hypercapnic

EXPERIMENTAL

Participants inhale ambient air, the hypercapnic gas mixture, and ambient air.

Other: Hypercapnic

Hypoxic and Hypercapnic

EXPERIMENTAL

Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air.

Other: Hypoxic and Hypercapnic

Interventions

Hypoxic OTHER

Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.

Hypoxic

Hypercapnic OTHER

Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.

Hypercapnic

Hypoxic and Hypercapnic OTHER

Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.

Hypoxic and Hypercapnic

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy volunteers

You may not qualify if:

• pregnancy
• severe cardiovascular conditions
• severe asthma or other severe respiratory conditions
• injury to the upper limbs or hands that could affect the peripheral perfusion
• diabetes
• hypotension or hypertension

Sponsors & Collaborators

• Czech Technical University in Prague: lead

Study Sites (1)

Czech Technical University in Prague

Kladno, 27201, Czechia

Location

MeSH Terms

Conditions

Hypoxia; Hypercapnia; Cardiac Output, High

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Heart Diseases; Cardiovascular Diseases

Study Officials

• Karel Roubik, Professor

  Czech Technical University in Prague

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The participant undergoes all three phases of the experiment and the participant does not know which one is it.
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Interventional single blinded randomized crossover prospective study. All participants go through all study arms, in random order.

Study Record Dates

• First Submitted: June 25, 2022
• First Posted: July 1, 2022
• Study Start: June 22, 2022
• Primary Completion: March 30, 2024
• Study Completion: June 30, 2024
• Last Updated: March 11, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CZ (1)