Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

NCT05948527 | Completed

• 1 other identifier: R.22.12.1978.R1.R2
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).

Conditions

Hypercapnia

Keywords

hypercapnia; high flow nasal canula

Outcome Measures

Primary Outcomes (1)

• Arterial Blood Gases changes

  The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission.

  48 hours

Secondary Outcomes (1)

• Number of participants in need for ventilation

  7 days

Study Arms (1)

with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30)

EXPERIMENTAL

with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disorders

Device: high flow nasal canula

Interventions

high flow nasal canula DEVICE

administration of high flow nasal canula at initial flow 35 liters per minute and Fio2 (fraction of inspired oxygen of 50%) with titration to reach oxygen saturation of 88-92%.

with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30)

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients with mild Hypercapnia

You may not qualify if:

• Excluded cases had age less than 18 years or pediatric group .
• patients with their mental state altered, confused, comatose, severe agitation or non cooperative
• Cases with moderate or severe Hypercapnia
• cases in need for immediate invasive mechanical ventilation
• cases with respiratory rate more than 35 breath per minute.
• cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles
• Shock , hemodynamic instability, post arrest cases,
• cases with facial trauma or severe nasal deformity,
• Patients with sleep breathing disorders or upper airway obstruction
• patients with history of home ventilation prior admission

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura University Hospitals

Al Mansurah, Dakahlia Governorate, 35511, Egypt

Location

MeSH Terms

Conditions

Hypercapnia

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 24, 2023
• First Posted: July 17, 2023
• Study Start: January 1, 2023
• Primary Completion: July 1, 2023
• Study Completion: July 1, 2023
• Last Updated: July 17, 2023

Record last verified: 2023-06

Locations

EG (1)