NCT05426057

Brief Summary

The goal of this study is to evaluate in an effectiveness-implementation type I hybrid trial, an enhanced version of eHealth Familias Unidas for reducing depressive, anxious symptoms and suicide behavior in Hispanic youth. The study will use a randomized rollout design with 18 pediatric primary care clinics in the South Florida area.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
468

participants targeted

Target at P75+ for not_applicable

Timeline
7mo left

Started Apr 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

17 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress88%
Apr 2022Nov 2026

Study Start

First participant enrolled

April 26, 2022

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

June 15, 2022

Completed
6 days until next milestone

First Posted

Study publicly available on registry

June 21, 2022

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2026

Last Updated

August 6, 2025

Status Verified

August 1, 2025

Enrollment Period

4.6 years

First QC Date

June 15, 2022

Last Update Submit

August 4, 2025

Conditions

Keywords

effectiveness-implementation type 1 hybrid trialLatinx mental health in primary careLatinx adolescenteHealth interventionFamilias Unidasintervention sustainmentparent-centeredfamily functioningsexual risk behavior

Outcome Measures

Primary Outcomes (5)

  • Depression symptoms

    Change in depression symptom severity will be measured using the Kiddie Computerized Adaptive Test (K-CAT®). K-CAT® measures severity on a scale of 0 to 100 with higher scores indicating greater depression symptom severity.

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Anxiety symptoms

    Change in anxiety symptom severity will be measured using the Kiddie Computerized Adaptive Test (K-CAT®). K-CAT® measures severity on a scale of 0 to 100 with higher scores indicating greater anxiety symptom severity.

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Suicidality

    Change in suicidality severity will be measured using the Kiddie Computerized Adaptive Test (K-CAT®). K-CAT® measures severity on a scale of 0 to 100 with higher scores indicating greater suicidality symptom severity.

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Change in drug use

    Change in drug use will be reported as the number of days drug use was reported over the last 90 days.

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Center for Epidemiologic Studies Depression Scale (CESD)

    Change in depression symptoms will be assessed with the CESD. Scores range from 0 to 60 with higher scores indicating the presence of more symptoms.

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

Secondary Outcomes (4)

  • Change in Family Functioning as assessed by the Parenting Practices Questionnaire

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Change in Family Functioning as assessed by the Parent Relationship with Peer Group

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Change in Family Functioning as assessed by the Parent-Adolescent Communication Scale

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

  • Change in unprotected sexual behavior

    Baseline to 3 months, baseline to 6 months, baseline to 18 months

Study Arms (2)

eHealth Familias Unidas

EXPERIMENTAL

Participants in this group will receive eHealth Familias Unidas-Mental Health. The intervention consists of nine video parent group sessions, one video adolescent session, and four family sessions (parents participate in a total of 13 sessions, adolescents participate in a total of five sessions) that will be delivered by a facilitator to the parent-child dyad via web-conferencing software across 13 weeks.

Behavioral: eHealth Familias Unidas Mental Health

Prevention as Usual Control

NO INTERVENTION

In this condition, participants will not receive an intervention, only the standard of care services which may include information and referral.

Interventions

eHealth Familias Unidas is a program designed to target mental health and suicide ideation and behavior. It focuses on promoting mental health by strengthening family and interpersonal protective factors. The program is provided online over a total of 13 sessions: 9 video parent group sessions, each lasting 20-40 minutes in Spanish and 4 web family sessions lasting 45 minutes in either Spanish or English, depending on participant language preference. The video parent group sessions consist of: 1) culturally syntonic telenovela/soap opera series, 2) videotaped parent group discussions, 3) interactive exercises. Web family sessions will be conducted by a trained pediatric staff member.

eHealth Familias Unidas

Eligibility Criteria

Age12 Years - 16 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Female and male adolescents, who self-identify as Hispanic (or Latino(a))
  • Adolescent between the ages of 12 - 16 years
  • Adolescent living with an adult primary caregiver who is willing to participate
  • Families must have broadband internet access on a device, including (but not limited to) a smartphone, iPad, tablet, computer at their home or other location (e.g., school, library, etc.)
  • Families screening positive on poor family communication (a score of less than 75 on the communication measure; see measures) or youth reporting elevated depressive or anxiety symptom scores (defined as 70 to 90 on the K-CAT) or a history of suicide behavior (ideation or attempts).

You may not qualify if:

  • Families reporting plans to move out of the South Florida area during the study period.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (17)

Jessie Trice Community Health Center

Miami, Florida, 33010, United States

COMPLETED

Broward Community Health

Miami, Florida, 33021, United States

WITHDRAWN

Community Health of South Florida

Miami, Florida, 33023, United States

COMPLETED

Medlife Clinical Research

Miami, Florida, 33125, United States

COMPLETED

Prime Care Health

Miami, Florida, 33134, United States

COMPLETED

Care Resource

Miami, Florida, 33135, United States

COMPLETED

Mailman for Child Devlopment

Miami, Florida, 33136, United States

RECRUITING

Pediatric Mobile Clinic

Miami, Florida, 33136, United States

RECRUITING

UM Pediatric Mobile Clinic

Miami, Florida, 33136, United States

RECRUITING

UM UHealth Pediatrics at the Professional Arts Center

Miami, Florida, 33136, United States

RECRUITING

Borinquean Medical Centers

Miami, Florida, 33137, United States

RECRUITING

Belkys Bravo Clinic

Miami, Florida, 33145, United States

COMPLETED

Nicklaus Children Hospital

Miami, Florida, 33155, United States

COMPLETED

South Florida Pediatric Partners

Miami, Florida, 33173, United States

COMPLETED

Pediatric Consultants of Kendall, P.A.

Miami, Florida, 33175, United States

COMPLETED

UHealth Pediatrics at Kendall

Miami, Florida, 33176, United States

RECRUITING

Banyan Health Systems

Miami, Florida, 33189, United States

WITHDRAWN

Related Publications (1)

  • Estrada Y, Lozano A, Boga D, Tapia MI, Perrino T, Velazquez MR, Forster L, Torres N, Morales CV, Gwynn L, Beardslee WR, Brown CH, Prado G. eHealth Familias Unidas Mental Health: Protocol for an effectiveness-implementation hybrid Type 1 trial to scale a mental health preventive intervention for Hispanic youth in primary care settings. PLoS One. 2023 Apr 18;18(4):e0283987. doi: 10.1371/journal.pone.0283987. eCollection 2023.

MeSH Terms

Conditions

DepressionAnxiety DisordersSuicide

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorMental DisordersSelf-Injurious Behavior

Study Officials

  • Guillermo Prado, PhD

    University of Miami

    PRINCIPAL INVESTIGATOR
  • C. Hendricks Brown, PhD

    Northwestern University

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Guillermo Prado, PhD

CONTACT

Yannine Estrada, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 15, 2022

First Posted

June 21, 2022

Study Start

April 26, 2022

Primary Completion (Estimated)

November 30, 2026

Study Completion (Estimated)

November 30, 2026

Last Updated

August 6, 2025

Record last verified: 2025-08

Data Sharing

IPD Sharing
Will not share

Locations