Description of Physical Activity Effect on Neuromuscular Fatigue of Older People

NCT05413590 | Terminated

• 2 other identifiers: 21CH033ANSM
• Study Type: interventional
• Target: 93
• Locations: 1 country
• Sites: 1

Brief Summary

There is a decrease in cardiovascular and neuromuscular functions, which leads to reduced performance with advancing age. Physical activity provides health benefits, prevents and treats cardiovascular and neuromuscular disease. The aim of this project is to describe cardiovascular and neuromuscular function in active and sedentary subjects of different ages.

Conditions

Aging; Fatigue

Keywords

cardiovascular function; neuromuscular function; V02max

Outcome Measures

Primary Outcomes (1)

• Maximal voluntary contraction (MVC) of the knee extensor muscle measurement

  Maximal isometric force (maximal voluntary contraction, MVC) of the knee extensor muscle measured before and after an incremental test on a bicycle ergometer

  At 48 hours

Secondary Outcomes (11)

• Voluntary activation measurement (%)

  At 48 hours

• Maximal voluntary contraction (MVC) of the plantar flexor muscle measurement

  At 48 hours

• Maximal voluntary contraction (MVC) of the hand grip measurement

  At 48 hours

• Cardiac variability(ms)

  At 48 hours

• Muscle oxygenation (%)

  At 48 hours

Study Arms (6)

Young, Active group

ACTIVE COMPARATOR

From 18 to 35 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 Metabolic Equivalent of Task (MET)-minutes per week

Other: Questionnaires completion; Other: Isometric forces; Other: Energy cost

Young, sedentary group

ACTIVE COMPARATOR

From 18 to 35 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Other: Questionnaires completion; Other: Isometric forces; Other: Energy cost

Old, Active group

ACTIVE COMPARATOR

From 65 to 80 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week

Other: Questionnaires completion; Other: Isometric forces; Other: Energy cost

Old sedentary group

ACTIVE COMPARATOR

From 65 to 80 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Other: Questionnaires completion; Other: Isometric forces; Other: Energy cost

Very old, Active group

ACTIVE COMPARATOR

From 81 years old. The subjects will be considered as active if after completion of the Global Physical Activity Questionnaire (GPAQ), the subjects count: * at least 20 minutes of vigorous physical activity per day for 3 or more days per week OR * at least 30 minutes of moderate physical activity or walking per day for 5 or more days per week OR * At least 5 days of walking and moderate or vigorous physical activity, reaching a minimum of 600 MET-minutes per week

Other: Questionnaires completion; Other: Isometric forces; Other: Energy cost

Very old sedentary group

ACTIVE COMPARATOR

From 81 years old. Subjects who are below these thresholds will be considered as sedentary. To avoid including a subject who recently changed his lifestyle (sedentary becoming active or vice versa), the investigator will ensure the subject kept this physical activity level (expressed using the GPAQ) constant for the last 5 years.

Other: Questionnaires completion; Other: Isometric forces; Other: Energy cost

Interventions

Questionnaires completion OTHER

Cognitive tests, completing questionnaires, balance test, measuring cardiac variability and post-ischemic hyperemia. Assessments of neuromuscular function on a semi-recumbent ergometric bicycle.

Old sedentary group; Old, Active group; Very old sedentary group; Very old, Active group; Young, Active group; Young, sedentary group

Isometric forces OTHER

Measurement of the maximum isometric forces of the knee flexors, the plantar flexors of the ankle and the grip strength of the hand.

Old sedentary group; Old, Active group; Very old sedentary group; Very old, Active group; Young, Active group; Young, sedentary group

Energy cost OTHER

Measurement of feet pressure and measurement of the energy cost. Maximum test on an endocycle (classic) to determine VO2max.

Old sedentary group; Old, Active group; Very old sedentary group; Very old, Active group; Young, Active group; Young, sedentary group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18 to 35 for the young group, between 65 and 80 for the old group and over 80 for the very old group.
• Signed consent for the study obtained
• Subject affiliated or entitled to a social security scheme

You may not qualify if:

• Pathology or surgical intervention causing a locomotor disorder
• Neurological, cardiovascular or psychological pathology
• Participants will be excluded if resting or exercise ECG responses show any abnormality, or if resting Heart Rate (HR) \> 100 bmp, resting blood pressure \> 144 (systolic) / 95 (diastolic) mmHg, pulmonary and or cardiac disease that could affect the health of the participant (arrhythmias and stroke)
• Mini-Mental State Examination score \< 20 (\>80 years old)
• Significant change in the amount of physical practice over the last 5 years.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

Chu de Saint-Etienne

Saint-Etienne, 42055, France

Location

Related Publications (1)

• Luneau E, Rozand V, Murias JM, Millet GY. Effect of Habitual Physical Activity on Strength Loss and Fatigability in Old and Very Old Men. Scand J Med Sci Sports. 2025 Dec;35(12):e70176. doi: 10.1111/sms.70176.

  PMID: 41343292 DERIVED

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• LEONARD FEASSON, PHD

  Centre Hospitalier Universitaire de Saint Etienne

  PRINCIPAL INVESTIGATOR

• Guillaume MILLET, PhD

  UNIVERSITE DE SAINT ETIENNE

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2022
• First Posted: June 10, 2022
• Study Start: November 30, 2021
• Primary Completion: May 23, 2023
• Study Completion: June 6, 2023
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)