Exercise Training and Respiratory Muscle Training in Individuals With Metabolic Syndrome(METS)

NCT05413434 | Completed DMC

• 1 other identifier: HacettepeKPR
• Study Type: interventional
• Target: 38
• Locations: 1 country
• Sites: 1

Brief Summary

The study will be conducted on individuals with Metabolic Syndrome. There are many studies showing that aerobic exercise provides significant improvements in waist circumference, fasting glucose, high-density lipoprotein cholesterol (HDL-C), Triglyceride (TG), systolic and diastolic blood pressure (SBP-DBP), and cardiorespiratory fitness on METS parameters. However, although the beneficial effects of physical activity are known, only half of the population adheres to the 150 minutes of moderate-intensity physical activity per week recommendation. High-intensity interval training (HIIT) is a type of training that uses near-maximal intensities in short-term sessions. HIIT has been used to improve compliance because it requires less time to treat patients with cardiometabolic disease. Compared to continuous aerobic exercise, this type of training has been shown to be an effective alternative for improving maximum oxygen consumption (VO2 max), blood pressure, heart function, glucose and lipid metabolism, and markers of oxidative stress and inflammation. In the literature, HIIT has been studied in patients with METS and has been shown to be effective. In addition, a study showed that seven-day respiratory muscle training was also effective on METS parameters, but there is no study showing the long-term effects of respiratory muscle training in this patient group. Therefore, in our study, researchers aimed to show the effects of respiratory muscle training given with HIIT on METS parameters.

Conditions

Metabolic Syndrome

Keywords

metabolic syndrome; inspiratory muscle training; high intensity interval training; exercise

Outcome Measures

Primary Outcomes (1)

• VO2max

  Cardiorespiratory fitness will be performed using a cardiopulmonary exercise test (CPET) with a treadmill, using the measurement method (breath by breath) with each breath. The modified Bruce protocol will be applied.VO2max will be recorded in ml/kg/min.

  8 weeks

Secondary Outcomes (17)

• functional capacity

  8 weeks

• flexibility

  8 weeks

• systolic and diastolic blood pressure

  8 weeks

• C-Reactive Protein (CRP)

  8 weeks

• Low Density Lipoprotein Cholesterol (LDL-C)

  8 weeks

Study Arms (3)

HIIT with a supervisor

EXPERIMENTAL

These individuals will be given HIIT training on the treadmill, accompanied by a physiotherapist, 3 days a week for 8 weeks.

Other: exercise

Hiit and respiratory muscle training with a supervisor

EXPERIMENTAL

HIIT program and respiratory muscle training will be applied to these individuals 3 days a week for 8 weeks.

Other: exercise; Device: inspiratory muscle training

control group

NO INTERVENTION

The importance of physical activity will be explained and appropriate physical activity recommendations will be made.

Interventions

exercise OTHER

high-intensity interval training will be performed on the treadmill.

HIIT with a supervisor; Hiit and respiratory muscle training with a supervisor

inspiratory muscle training DEVICE

Respiratory muscle strength exercise will be performed with the respiratory muscle strengthening device 'POWERbreathe Classic Light Resistance'.

Hiit and respiratory muscle training with a supervisor

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• METS will be defined according to the National Adult Cholesterol Education Program Adult Treatment Panel III. Patients with at least three or more of the following five characteristics will be included in the study:
• Waist circumference ≥102 cm for men or ≥88 cm for women;
• blood pressure above 130/85 mmHg;
• Fasting blood glucose (FG) ≥100 mg/dL;
• Blood TG ≥150 mg/dL; and
• HDL-C \< 40 mg/dL for men and \< 50 mg/dL for women.
• Not participating in any physical activity program (≤2 physical activity days per week ≤ 30 minutes per session).
• years
• to walk and cooperate
• to participate in the research

You may not qualify if:

• heart failure,
• pectoris,
• of myocardial infarction or stroke in less than one year,
• hypertension,
• cardiovascular or kidney disease,
• with peripheral vascular disease and any disease associated with exercise intolerance will be excluded.

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Metabolic Syndrome; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• oğuz uyaroglu, PHD

  Hacettepe University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: The physician who referred patients to the study and the participants were blind to the study.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master off degree

Model Details: randomized controlled

Study Record Dates

• First Submitted: March 6, 2022
• First Posted: June 10, 2022
• Study Start: April 1, 2022
• Primary Completion: March 1, 2023
• Study Completion: April 1, 2023
• Last Updated: August 15, 2023

Record last verified: 2023-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)