Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
The Effect of Ischemic Preconditioning and Physical Exercise on the Endocrine Function of Skeletal Muscle - the Effect of CoQ10 Supplementation. In Vivo and in Vitro Studies.
1 other identifier
interventional
100
1 country
1
Brief Summary
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the skeletal muscles. In the project, several research questions will be evaluated e.g. what is the relationship between oxidative stress parameters, uric acid concentration and nitric oxide degradation products in groups of people undergoing two-week training in ischemic training, or what is the relationship between the expression of genes associated with muscle cell growth (e.g. myostatin gene) and the effect of ischemia preconditioning training etc.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2023
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 25, 2022
CompletedFirst Posted
Study publicly available on registry
June 9, 2022
CompletedStudy Start
First participant enrolled
March 1, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
September 30, 2026
ExpectedJanuary 4, 2023
January 1, 2023
5 months
May 25, 2022
January 2, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
The effects of IPC on physical performance
IPC training will be combined with endurance exercise and VO2max and serum Lactate will be measured
8 weeks
The effects of CoQ10 supplementation on physical performance
CoQ10 supplementation combined with endurance training will be evaluated for endurance improvement in young men. VO2max, myokines, genes associated with the stress response will be measured
8 weeks
The effects of CoQ10 supplementation and IPC on physical performance
CoQ10 supplementation combined with IPC and endurance training will be evaluated for endurance improvement in young men. VO2max, myokines, genes associated with the stress response, ulic acid will be measured
8 weeks
Study Arms (4)
Supplemented population 300mg
PLACEBO COMPARATORSupplemented population 300mg/24h CoQ10 - 25 participants
Training and IPC preconditioning
EXPERIMENTALGroup subjected to training and preconditioning by ischemia (IPC training) - 25 participants,
Control group (placebo)
PLACEBO COMPARATORControl group to CoQ10 supplementation (placebo)- 25 participants
IPC control group
SHAM COMPARATORIPC control group - 25 participants
Interventions
Young men training endurance running will be supplemented with CoQ10
Young men training endurance running will undergo IPC training
Young men training endurance running will undergo IPC training combined with CoQ10 supplementation
Young men training endurance running will undergo sham IPC training combined with placebo supplementation
Eligibility Criteria
You may qualify if:
- not taking medication during the study,
- good health (no concomitant injuries),
- negative history of cardiovascular disorders, autonomic nervous system, mental disorders, cerebrospinal injuries and other diseases that may directly affect the results obtained.
You may not qualify if:
- Lack of consent to participate in the research project or negative result of medical examinations.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Jedrzej Antosiewicz
Gdansk, Pomeranian Voivodeship, 80-210, Poland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 25, 2022
First Posted
June 9, 2022
Study Start
March 1, 2023
Primary Completion
July 31, 2023
Study Completion (Estimated)
September 30, 2026
Last Updated
January 4, 2023
Record last verified: 2023-01