Investigating the Effect of Whole-fruit Coffee Extract on Exercise Performance

NCT05404841 | Completed DMC

• 1 other identifier: 2021-10-20-B-05
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 2

Brief Summary

Caffeine is a widely used efficacious supplement by both the general public, and athletes, with the goal of improving performance. The effects of caffeine alone are well known, but it is not clear whether a multi-ingredient supplement (containing both caffeine and polyphenols) can affect exercise performance. This study aims to determine if a low dose of caffeine, in the form of a whole-fruit coffee extract also containing polyphenols, can improve exercise performance compared to a placebo condition, with a secondary objective of identifying if this supplement can improve post exercise refuelling (glycogen resynthesis). Participants will consume either the supplement or a placebo before engaging in an exercise protocol. Muscle biopsies will then be obtained so as to measure subsequent glycogen resynthesis, with multiple blood samples being taken through the day. The following morning another biopsy will be taken before the exercise protocol will be repeated. This research will inform us of the efficacy of caffeine and polyphenols on improving exercise performance.

Conditions

Caffine and Endurance Performance

Outcome Measures

Primary Outcomes (1)

• Exercise performance

  Amount of work completed in 15 minutes

  15 Minitues

Secondary Outcomes (6)

• Glycogen Resynthesis

  24 Hours

• Alertness

  1 Minitue

• Motivation

  1 Minitue

• Rate of perceived exertion

  1 Minitue

• Urine osmolarity

  24 Hours

Study Arms (2)

CoffeeBerry Supplement

EXPERIMENTAL

Caffeine and polyphenol supplement

Dietary Supplement: CoffeeBerry Supplement

Placebo

PLACEBO COMPARATOR

Placebo

Dietary Supplement: Placebo

Interventions

CoffeeBerry Supplement DIETARY_SUPPLEMENT

A Coffeeberry supplement containing 200mg Caffeine and 14mg polyphenols, manufactured by FutureCeuticals Inc.,

CoffeeBerry Supplement

Placebo DIETARY_SUPPLEMENT

Placebo

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• Allergy to Lidocaine
• Any diagnosed metabolic health condition
• Pregnant
• Non-habitual caffeine intake
• Smoker
• No endurance training
• Diagnosed Cardiovascular disease
• Beta-Blockers
• Recent history of musculoskeletal injury
• Age 18-40
• Heathy
• Highly trained endurance athletes (V̇O2max: males \>55 and females \>50 mL⋅kg bm-1⋅min-1)
• Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.

Sponsors & Collaborators

• University of Exeter: lead
• VDF FutureCeuticals Inc.: collaborator

Study Sites (2)

Sport & Health Sciences University of Exeter

Exeter, Devon, EX1 2LU, United Kingdom

Location

University of Exeter

Exeter, EX1 2LU, United Kingdom

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 10, 2022
• First Posted: June 3, 2022
• Study Start: February 4, 2022
• Primary Completion: January 25, 2023
• Study Completion: January 25, 2023
• Last Updated: March 22, 2023

Record last verified: 2023-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (2)