NCT05230862

Brief Summary

The aim of the present study is to test the effect of ingesting a multi-ingredient pre- exercise supplement containing caffeine, creatine, beta-alanine and L-Citrulline compared to a placebo, on endurance exercise performance.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable healthy-volunteers

Timeline
Completed

Started Dec 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 2, 2021

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

January 10, 2022

Completed
1 month until next milestone

First Posted

Study publicly available on registry

February 9, 2022

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2022

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2022

Completed
Last Updated

July 31, 2025

Status Verified

July 1, 2025

Enrollment Period

9 months

First QC Date

January 10, 2022

Last Update Submit

July 28, 2025

Conditions

Healthy Volunteers

Outcome Measures

Primary Outcomes (1)

  • Exercise Performance

    Work done during 15 min time trial (TT)

    15 Minitues

Secondary Outcomes (4)

  • Alertness

    1 Hour

  • Motivation

    1 Hour

  • Rate of perceived exertion

    1 Hour

  • Gas analysis

    1 Hour

Study Arms (2)

Ladder Supplement

EXPERIMENTAL

Ladder Supplement

Dietary Supplement: Ladder Supplement

Placebo

PLACEBO COMPARATOR

Placebo

Dietary Supplement: Placebo

Interventions

Ladder SupplementDIETARY_SUPPLEMENT

Caffeine 200mg L-Theanine 200mg L-Citrulline 6g Creatine 5g Beta-Alanine 1.6g Phosphatidylserine 100mg

Ladder Supplement
PlaceboDIETARY_SUPPLEMENT

Placebo

Placebo

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may not qualify if:

  • Any diagnosed metabolic health condition
  • Pregnant
  • Non-habitual caffeine intake
  • Smoker
  • No endurance training
  • Diagnosed Cardiovascular disease
  • Recent history of musculoskeletal injury
  • Anti-depressant and anti-anxiety medication
  • Age 18-40
  • Healthy
  • Highly trained endurance athletes (V̇O2max: males \>55 and females \>50 mL⋅kg bm-1⋅min-1)
  • Both males and females are allowed to participate. If females are on the oral contraceptive pill they are to be tested on consecutive weeks. If they are not on the oral contraceptive pill, then female subjects are to be tested every 4 weeks, at the same point of their menstrual cycle.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Sport and Health Sciences

Exeter, EX4, United Kingdom

Location

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 10, 2022

First Posted

February 9, 2022

Study Start

December 2, 2021

Primary Completion

August 31, 2022

Study Completion

September 30, 2022

Last Updated

July 31, 2025

Record last verified: 2025-07

Locations

GB(1)