The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

NCT05391620 | Completed

• 1 other identifier: 2020276
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population. 3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of \~ 70% of one repetition maximal (1RM). Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes. The investigators collect blood sample before exercice, after HIIT and after RT. It is randomized cross-over study.

Conditions

Heart Failure; Resistance Training; Coronary Artery Disease

Keywords

Cardiac rehabilition; exercise therapy; metabolic stress

Outcome Measures

Primary Outcomes (6)

• Change in Lactate

  mmol/l

  within 2 minutes after TR training session on day 1

• change in Testosterone

  nmol/l

  within 2 minutes after TR training session on day 1

• change Glucocorticoid Cortisol

  nmol/l

  within 2 minutes after TR training session on day 1

• change in Growth Hormone

  ng/ml

  within 2 minutes after TR training session on day 1

• change in ph

  venoust

  within 2 minutes after TR training session on day 1

• change PCO2 venoust

  mm Hg

  within 2 minutes after TR training session on day 1

Secondary Outcomes (2)

• Borg scale

  within 4 minutes after TR training session on day 1

• Pleasure of the session scale

  within 4 minutes after TR training session on day 1

Study Arms (2)

CAD group

EXPERIMENTAL

Coronary artery diseases

Other: Cardiac rehabilitation with 3/7 method; Other: Cardiac rehabilitation with 3X9 method

HFrEF group

EXPERIMENTAL

Heart Failure with reduced Ejection Fraction

Other: Cardiac rehabilitation with 3/7 method; Other: Cardiac rehabilitation with 3X9 method

Interventions

Cardiac rehabilitation with 3/7 method OTHER

HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.

Also known as: 3/7 method

CAD group; HFrEF group

Cardiac rehabilitation with 3X9 method OTHER

HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned

Also known as: 3X9 method

CAD group; HFrEF group

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical Coronary artery diseases
• Heart failure with reduced ejection fraction

You may not qualify if:

• angina
• acutely decompensated heart failure
• electrocardiographic evidence of ischemia
• significant valvular disease
• orthopedic/neurologic disorders that limited exercise

Sponsors & Collaborators

• Université Libre de Bruxelles: lead

Study Sites (1)

Erasme Hospital

Brussels, 1070, Belgium

Location

Related Publications (1)

• Mang ZA, Realzola RA, Ducharme J, Bellissimo GF, Beam JR, Mermier C, de Castro Magalhaes F, Kravitz L, Amorim FT. The effect of repetition tempo on cardiovascular and metabolic stress when time under tension is matched during lower body exercise. Eur J Appl Physiol. 2022 Jun;122(6):1485-1495. doi: 10.1007/s00421-022-04941-3. Epub 2022 Apr 8.

  PMID: 35394146 BACKGROUND

MeSH Terms

Conditions

Heart Failure; Coronary Artery Disease

Interventions

Cardiac Rehabilitation

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Coronary Disease; Myocardial Ischemia; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Philippe van de borne, Professor

  Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 7, 2022
• First Posted: May 26, 2022
• Study Start: February 22, 2022
• Primary Completion: June 10, 2022
• Study Completion: October 25, 2022
• Last Updated: February 14, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)