NCT05390541

Brief Summary

The proposed intervention is a web-based intervention guided by theoretical components to increase HIV home testing among Black women at risk for HIV and sexually transmitted infections (STIs) in a HIV hotspot in the South. The intervention will promote using the home test, linkage to care, and linkage to pre-exposure prophylaxis (PrEP) evaluation. The intervention has the potential to be implemented on a large scale and tailored based on location and population to increase testing, treatment, and PrEP adoption.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
31

participants targeted

Target at below P25 for not_applicable hiv

Timeline
Completed

Started Feb 2022

Typical duration for not_applicable hiv

Geographic Reach
1 country

4 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 2, 2022

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

May 16, 2022

Completed
9 days until next milestone

First Posted

Study publicly available on registry

May 25, 2022

Completed
3.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 30, 2025

Completed
10 months until next milestone

Results Posted

Study results publicly available

April 24, 2026

Completed
Last Updated

April 27, 2026

Status Verified

April 1, 2026

Enrollment Period

3.4 years

First QC Date

May 16, 2022

Results QC Date

April 3, 2026

Last Update Submit

April 23, 2026

Conditions

Outcome Measures

Primary Outcomes (5)

  • Number of Participants Who Used Home HIV Test

    Self-report of use of HIV test within 4 days of receiving the test.

    4 days

  • Number of Participants Who Mailed HIV Test

    Self-report of mailing at-home HIV test within 2 days; verification from Kind Clinic that test was received.

    2 days

  • Number of Participants Who Checked HIV Results

    Self-report of HIV test results checked within 7 days after Kind Clinic receives the at home HIV test; results verified by Kind Clinic.

    7 days

  • Number of HIV Positive Participants Who Received HIV Treatment

    If HIV test is positive, self-report of treatment for HIV; results verified by Kind Clinic.

    7 days

  • Number of HIV Negative Participants Who Attended PrEP Evaluation

    If HIV test is negative, self-report of attending appointment for PrEP evaluation within 7 days after receipt of negative HIV test; appointment attendance verified by Kind Clinic.

    7 days

Secondary Outcomes (4)

  • Number of Participants Who Used Home STI Test

    4 days

  • Number of Participants Who Received STI Treatment

    Within 7 days of positive HIV test

  • Feasibility of Intervention Measure (FIM) Score

    Post intervention up to 1 week

  • Acceptability of Intervention Measure (AIM) Score

    Post intervention up to 1 week

Other Outcomes (6)

  • Recruitment Materials Acceptability Developed by Study Team

    Baseline

  • Acceptability of Measures Developed by Study Team

    Post intervention up to 1 week

  • Acceptability of Program Instructions Developed by Study Team

    Post intervention up to 1 week

  • +3 more other outcomes

Study Arms (2)

Educational Control

ACTIVE COMPARATOR

Participants will receive a generic standard of care via a combination of videos, audio, and text/graphics across 5 sessions during 4 weeks.

Other: Educational Control

Empowered to Test Yourself

EXPERIMENTAL

There will be 5 tailored web based sessions of the intervention over 4 weeks, all of which will follow the same format.

Behavioral: Empowered to Test Yourself

Interventions

There will be 5 sessions of the intervention, all of which will follow the same format. Participants will be sent push notifications for each session. Each session will begin with using relevant constructs from sIMB (i.e., information and behavioral skills). Next, participants will choose positive outcomes resulting from the behavior, barriers to performing the behavior (mental contrasting), select situational cues and action plans to overcome selected barriers (implementation intentions), and practice typing in implementation intentions and positive outcomes from memory (memory practice). To ensure participants retain the implementation intentions, the investigators will use memory practice. Participants will be asked to self-code if the participant is correct or incorrect. Lastly, participants will learn behavioral skills to engage in each of the 5 actions to increase self-efficacy.

Empowered to Test Yourself

Participants will receive the HIV/STI home testing kit, instructions to mail in the kit, notification when results are ready to check online, treatment from a provider at Kind Clinic for positive results, and referral to Kind Clinic for PrEP. Each session and assessment will occur every 3 days. Session 1: Basic information about STIs. Session 2: HIV and stigma, basic information about HIV, and HIV transmission facts and myths. Session 3: Four stories about different people who are HIV-positive, how HIV was contracted, and one story about a woman who contracted herpes and how to all cope and live healthy lives. Session 4: How to disclose positive STI status. Session 5: Basic information about PrEP, and information on how to correctly use a male condom, female condom, and dental dam.

Educational Control

Eligibility Criteria

Age15 Years - 59 Years
Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsCisgender Black women are eligible for this study.
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • years of age
  • Identify as a cisgender woman
  • Identify as Black/African-American (Black/African American mixed race/ethnicity is included)
  • Read/speak/type in English
  • Have not tested for HIV/STIs in the past 12 months
  • Live in urban or suburban areas in Austin, Dallas, Houston, or San Antonio, Texas
  • Had condom-less sex in the past 6 months
  • Have access to a device (i.e., smart phone, tablet, or computer/laptop)
  • Have access to the internet
  • Reports at least one of the following:
  • A sexual partner who is living with HIV
  • Does not use or uses condoms inconsistently for vaginal/anal sex
  • Injects drugs with a partner who is living with HIV
  • Shared drug preparation or injection equipment with others

You may not qualify if:

  • Over the age of 59 or younger than 15 years
  • Identify as any gender other than a cisgender woman
  • Identify as any race/ethnicity other than Black/African-American
  • Are unable to fluently speak, read, or type in English
  • Had an HIV/STI test within the past 12 months
  • Live in rural areas of Texas or urban/suburban areas other than Austin, Dallas, Houston, or San Antonio, Texas
  • Use condoms 100% of the time during vaginal/anal sex in the past 6 months
  • Do not have access to a device (i.e., smart phone, tablet, or computer/laptop)
  • Do not have access to the internet
  • Reports that they do not have a sexual partner who is living with HIV, always uses condoms for vaginal/anal sex, does not inject drugs with a partner living with HIV, and does not share drug preparation or injection equipment with others.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (4)

Johns Hopkins Bloomberg School of Public Health

Austin, Texas, 78701, United States

Location

Johns Hopkins Bloomberg School of Public Health

Dallas, Texas, 75202, United States

Location

Johns Hopkins Bloomberg School of Public Health

Houston, Texas, 77019, United States

Location

Johns Hopkins Bloomberg School of Public Health

San Antonio, Texas, 78205, United States

Location

Related Publications (2)

  • Weiner BJ, Lewis CC, Stanick C, Powell BJ, Dorsey CN, Clary AS, Boynton MH, Halko H. Psychometric assessment of three newly developed implementation outcome measures. Implement Sci. 2017 Aug 29;12(1):108. doi: 10.1186/s13012-017-0635-3.

    PMID: 28851459BACKGROUND
  • Ondersma SJ, Chase SK, Svikis DS, Schuster CR. Computer-based brief motivational intervention for perinatal drug use. J Subst Abuse Treat. 2005 Jun;28(4):305-12. doi: 10.1016/j.jsat.2005.02.004.

    PMID: 15925264BACKGROUND

MeSH Terms

Conditions

Acquired Immunodeficiency SyndromeSexually Transmitted Diseases

Condition Hierarchy (Ancestors)

HIV InfectionsBlood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesSlow Virus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System DiseasesDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Dr. Liesl Nydegger
Organization
Johns Hopkins Bloomberg School of Public Health

Study Officials

  • Liesl A Nydegger, PhD

    Johns Hopkins Bloomberg School of Public Health

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: Participants will be randomly assigned to the intervention or educational control conditions. Participants in both conditions will receive HIV/STI self-testing kits. The intervention condition will have 5 tailored sessions over 4 weeks. The education control condition will have 5 generic sessions equally dispersed over 4 weeks.
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 16, 2022

First Posted

May 25, 2022

Study Start

February 2, 2022

Primary Completion

June 30, 2025

Study Completion

June 30, 2025

Last Updated

April 27, 2026

Results First Posted

April 24, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

The investigators will share the findings through presentations at national and international conferences. They will also seek to publish findings in key scientific outlets. The investigators will assure that they are in compliance with NIH requirements to deposit peer reviewed publications with the PubMed Central repository, thus facilitating dissemination of findings to the scientific community and general public. The investigators will willingly share the data with scholars wishing to collaborate on publications related to the project. To improve the ease of collaboration the investigators will thoroughly document all decisions regarding how they classify and code our transcribed and quantitative data.

Shared Documents
STUDY PROTOCOL, SAP, CSR
Time Frame
Data will become available in the Texas Data repository within 1 year after study completion where it will remain for 5 years.

Locations