NCT05390437

Brief Summary

nutritional intervention with ready to use therapeutic food (plumpy nut. by Unicef) and Prebiotics supplimentation ( Galactooligosaccarides). will be given to uncomplicated severe acute malnourished children of 06 months to 59 months of age in southern Punjab Pakistan.one group will be given Ready to use therapeutic food and placebo the other group will be given Prebiotics supplementation (Galacto oligosaccharides) with RUTF ( Ready to use therapeutic Foods).for 60 days primary out will be Mid Upper Arm Circumference \>11.5 centimetre

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 4, 2020

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 15, 2020

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

December 13, 2021

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 15, 2022

Completed
2 months until next milestone

First Posted

Study publicly available on registry

May 25, 2022

Completed
Last Updated

May 25, 2022

Status Verified

April 1, 2022

Enrollment Period

9 months

First QC Date

December 13, 2021

Last Update Submit

May 19, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Nutritional cure

    Mid Upper Arm Circumference of left arm is measured at the mid point between the tips of shoulder and elbow.It is measured by MUAC tape . More than 11.5 centimetre according to WHO criteria will be primary outcome

    60 Days

Secondary Outcomes (1)

  • Weight gain in kilograms

    60 Days

Study Arms (2)

control group

PLACEBO COMPARATOR

starch (placebo) 4 grams per day for 60 days

Dietary Supplement: Ready to use theraputic food (RUTF) and Starch (placebo)

Interventional group

EXPERIMENTAL

Prebiotics (GOS) Galactooligosaccharides 4 gram per day for 60 days

Dietary Supplement: Nutritional intervention with Ready to use theraputic food (RUTF) and prebiotic GOS (galacto oligosaccharides) in combination

Interventions

4gm of prebiotic GOS ( Galactooligosaccharides) and Ready to use theraputic food (RUTF) as per WHO standard on daily basis for 60 Days

Interventional group

Ready to use therapeutic food (RUTF) as per WHO standard and (Starch Placebo) soluble in water and mix in food on daily basis for 60 Days

control group

Eligibility Criteria

Age6 Months - 59 Months
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Uncomplicated Severely Acute Malnourished Children

You may not qualify if:

  • Severely Acute Malnourished children with complication

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

DG Khan

Dera Ghazi Khan, Punjab Province, 32200, Pakistan

Location

MeSH Terms

Conditions

Child Nutrition Disorders

Interventions

Starch

Condition Hierarchy (Ancestors)

Nutrition DisordersNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

GlucansBiopolymersPolymersMacromolecular SubstancesDietary CarbohydratesCarbohydratesPolysaccharides

Study Officials

  • javeria saleem, pub. health

    University of Punjab

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, CARE PROVIDER
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

December 13, 2021

First Posted

May 25, 2022

Study Start

January 4, 2020

Primary Completion

September 15, 2020

Study Completion

March 15, 2022

Last Updated

May 25, 2022

Record last verified: 2022-04

Locations