Effects of Motor Imagery and Action Observation in People With Multiple Sclerosis

NCT05377476 | Completed

• 1 other identifier: 2022-5
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

It was planned to examine the effects of motor imagery and action observation applied in addition to standard rehabilitation in people with multiple sclerosis on walking, fatigue, and trunk control.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; Motor Imagery; Action Observation; Walking; Fatigue; Trunk Control

Outcome Measures

Primary Outcomes (1)

• 6 Min Walking Test

  It will be used to measure walking distance. Before the test is administered, individuals will be given the necessary information and will be asked to walk as fast as possible on a 30-meter track for 6 minutes.

  6 week

Secondary Outcomes (5)

• Timed Up and Go Test

  6 week

• Multiple Sclerosis Walking Scale-12

  6 week

• RehaGait® (Hasomed, Magdeburg, Germany) Gait Analysis

  6 week

• Fatigue Severity Scale

  6 week

• Trunk Impairment Scale

  6 week

Study Arms (3)

Motor Imagery Group

EXPERIMENTAL

Individuals included in this group will receive 20 minutes of motor imagery training in addition to 40 minutes of standard rehabilitation. Patients will be trained 3 days a week for 6 weeks.

Other: Motor Imagery training; Other: standard rehabilitation

Action Observation Group

EXPERIMENTAL

Individuals included in this group will receive 20 minutes of action observation training in addition to 40 minutes of standard rehabilitation. Patients will be trained 3 days a week for 6 weeks.

Other: Action Observation training; Other: standard rehabilitation

Control Group

OTHER

Individuals included in this group will receive only 40 minutes of standard rehabilitation. Patients will be trained 3 days a week for 6 weeks.

Other: standard rehabilitation

Interventions

Motor Imagery training OTHER

Individuals included in this group will receive 20 minutes of motor imagery training in addition to 40 minutes of standard rehabilitation.

Motor Imagery Group

standard rehabilitation OTHER

40 minutes of standard rehabilitation.

Action Observation Group; Control Group; Motor Imagery Group

Action Observation training OTHER

Individuals included in this group will receive 20 minutes of action observation training in addition to 40 minutes of standard rehabilitation.

Action Observation Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Being between the ages of 18-65
• A definitive diagnosis of MS by a neurologist according to the 2017 McDonald Criteria
• Expanded Disability Status Scale (EDSS) score of 4.0 and below (it is determined routinely by the physician during the examination)
• Not having an attack in the last 3 months
• A minimum score of 4 in each motor imagery ability (internal visual imagery, external visual imagery, and kinesthetic imagery) on the Movement Imagery Questionnaire-3 (MIQ-3)

You may not qualify if:

• cognitive impairment, defined as a Mini-Mental State Examination (MMSE) score of less than 24
• Having another musculoskeletal, cardiovascular, pulmonary, metabolic, or neurological disease severe enough to preclude participation in the study.
• Having severe vision and hearing problems

Sponsors & Collaborators

• Hacettepe University: lead
• Bandırma Onyedi Eylül University: collaborator

Study Sites (1)

Hacettepe University

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Multiple Sclerosis; Fatigue

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Melike Sumeyye Ozen, M.Sc.

  Bandırma Onyedi Eylül University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: May 12, 2022
• First Posted: May 17, 2022
• Study Start: June 1, 2022
• Primary Completion: April 1, 2024
• Study Completion: June 1, 2024
• Last Updated: December 19, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)