Clinicopathological Characteristics of Colon Cancer in Young Age

NCT05365412 | Recruiting

• 1 other identifier: B-1901-514-112
• Study Type: observational
• Target: 1,400
• Locations: 1 country
• Sites: 1

Brief Summary

A Study on the Characteristics of Colorectal Cancer by Age and sex.

Conditions

Colo-rectal Cancer; Molecular Pathway Deregulation

Keywords

colorectal cancer; prognosis; sex difference

Outcome Measures

Primary Outcomes (1)

• Survival (overall/disease-specific) according to sex, molecular profiles and sex hormone receptors

  Time from diagnosis to death

  From date of enrollment until the date of death from colorectal cancer or from any cause, assessed up to 120 months

Secondary Outcomes (1)

• Disease-free survival according to sex, molecular profiles and sex hormone receptors

  From date of enrollment until the date of first documented recurrence of colorectal cancer, assessed up to 120 months

Study Arms (1)

Colorectal cancer group

Patients treated after being diagnosed with colorectal cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients treated after being diagnosed with colorectal cancer, and agreed to participate

You may qualify if:

• Patients treated after being diagnosed with colorectal cancer

You may not qualify if:

• Patients under age of 18 years, or patients who cannot choose whether to participate or not
• Patients who refuse to participate in the study

Sponsors & Collaborators

• Seoul National University Bundang Hospital: lead

Study Sites (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 463-707, South Korea

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Microinstability (MSS, MSI-L, MSI-H), DNA mismatch repair genes (hMLH1, hMSH2, hMSH6, hPMS2), RAS genes (KRAS, NRAS, HRAS), BRAF mutations from cancer tissue will be analyzed using immunohistochemistry (IHC) and reverse transcriptase polymerase chain reaction (RT-PCR). In addition, the expression of estrogen and androgen receptors will further be analyzed in each patient.

MeSH Terms

Conditions

Colonic Neoplasms; Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Nayoung Kim, MD, PhD

  Seoul National University Bundang Hospital

  STUDY CHAIR

Central Study Contacts

Nayoung Kim, MD, PhD

CONTACT

+82-31-787-7009; nakim49@snu.ac.kr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 24, 2022
• First Posted: May 9, 2022
• Study Start: January 1, 2019
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 28, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)