The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.
1 other identifier
interventional
90
1 country
2
Brief Summary
The aim of this project is to estimate the effects of therapy with dance and movement and Tai Chi on irisin plasma levels, a myokine with proven neuroprotective effects, in the context of baseline levels of cognitive function and physical performance in seniors over 65 years of age. It is empirically verified that physical activity can have a positive effect on cognitive function even in individuals with mild cognitive impairment. There may be a number of reasons why this is the case. Recently, research investigating the relationship between the secretion of certain myokines and their neuroprotective effects has gained importance. One of these myokines is irisin, which has recently been shown to have beneficial effects on the CNS by upregulating the expression of Brain Derived Neurotrophic Factor (BDNF) in the hippocampus in an animal model. Increased irisin levels as a consequence of exercise have recently been partially demonstrated in humans. What type of physical activity is most effective in terms of its effect on cognitive function in humans is another important scientific challenge. The possibility of influencing endocrine secretion of bioactive substances with proven effects on synaptic plasticity, neurogenesis and neuroprotection through effective therapies may help to combat neurodegenerative diseases, the prevalence of which is increasing with the average age of the population. According to Alzheimer's Disease International, 50 million people worldwide were affected by some form of neurodegenerative disease in 2017. The number of people affected is still rising. It is predicted that this number will reach 75 million sufferers by 2030 (https://www.alz.co.uk/research/statistics). Alzheimer's disease and multiple sclerosis are the two most common manifestations of neurodegenerative diseases. The effect of therapy with dance and movement and the effect of Tai Chi on blood irisin levels in the context of cognitive function and physical performance levels, has not yet been conclusively demonstrated.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2021
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2021
CompletedFirst Submitted
Initial submission to the registry
May 3, 2022
CompletedFirst Posted
Study publicly available on registry
May 5, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 30, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
January 30, 2023
CompletedMay 5, 2022
May 1, 2022
1.5 years
May 3, 2022
May 3, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in Irisin blood levels after 3 months of the intervention
Irisin levels measured from 9ml blood samples
baseline to 3 months
Difference in Irisin blood levels between the arms at 3 months
Irisin levels measured from 9ml blood samples
3 months
Secondary Outcomes (32)
Change in brain derived neurotrophic factor (BDNF) levels at 3 months
baseline to 3 months
Difference in brain derived neurotrophic factor (BDNF) levels at 3 months between the arms
3 months
Change from baseline cognitive function in the Amnesia Light and Brief Assessment (ALBA) at 3 months better outcome
baseline to 3 months
Difference in cognitive function in the Amnesia Light and Brief Assessment (ALBA) between the arms at 3 months
3 months
Change from baseline cognitive function in Semantic word recollection (category: animals, 1 min) at 3 months
baseline to 3 months
- +27 more secondary outcomes
Study Arms (4)
Therapy by Dance and Movement
EXPERIMENTALParticipants assigned to this part take part in Dance Movement Therapy twice a week (90 minutes each) for the duration of three months.
Control to Dance Movement Therapy
NO INTERVENTIONParticipants assigned to this arm take part in no particular activity for the three months.
Movement Therapy by Tai Chi
EXPERIMENTALParticipants assigned to this part take part inTai Chi class twice a week (90 minutes each) for the duration of three months.
Control to Tai Chi
NO INTERVENTIONParticipants assigned to this arm take part in no particular activity for the three months.
Interventions
Therapy by dance and movement is based on the principals of movement-analysis by Rudolf Laban and Irmgard Bartenieff. Participants will attend sessions twice a week (90 minutes each) for the duration of three months.
Tai Chi is based on somatic approach. Participants will attend sessions twice a week (90 minutes each) for the duration of three months.
Eligibility Criteria
You may qualify if:
- Is 65 years - 80 years in age
- His/her native language is Czech
- Is willing to visit the testing centre two times within 3-4 months
- Is willing to provide blood samples twice
- Is willing to take part in the movement therapy intervention
- is self-sufficient (handling finances, travelling without a chaperone, administration of medication, correct phone usage, filling forms, meal preparation)
- Has good vision; Can read and write, glasses are acceptable
- Has good hearing to hear and understand all instructions during examination
- Can walk well (walking aids are acceptable) to attend all the examinations and move well enough to take part in the movement therapy
You may not qualify if:
- Had been treated/Is currently being treated for the following psychiatric disorders: alcohol/medication/drug of abuse dependance, schizophrenia, psychotic disorder, bipolar disorder
- Had larger physical imparment which would interfere with the ability to take part in the Dance Movement and Tai Chi interventions
- Had severe neurological difficulties (epilepsy, stroke, severe head trauma, meningitis in the past 10 years, brain surgery, brain tumour, prolonged period(s) in an unconscious state - excluding general anaesthesia)
- Underwent a surgery/procedure under general anaesthesia in the past three years or has a planned procedure/surgery under general anaesthesia in the next 6 months over the course of this trial
- Is taking medication for depression or low mood
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Charles University, Czech Republiclead
- University Hospital Vinohradycollaborator
- Faculty of Physical Education and Sportcollaborator
Study Sites (2)
Faculty Hospital Vinohrady
Prague, Czechia
Faculty of Physical Education and Sport
Prague, Czechia
Related Publications (1)
Hola V, Polanska H, Jandova T, Jaklova Dytrtova J, Weinerova J, Steffl M, Kramperova V, Dadova K, Durkalec-Michalski K, Bartos A. The Effect of Two Somatic-Based Practices Dance and Martial Arts on Irisin, BDNF Levels and Cognitive and Physical Fitness in Older Adults: A Randomized Control Trial. Clin Interv Aging. 2024 Nov 6;19:1829-1842. doi: 10.2147/CIA.S482479. eCollection 2024.
PMID: 39525874DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Researcher
Study Record Dates
First Submitted
May 3, 2022
First Posted
May 5, 2022
Study Start
August 1, 2021
Primary Completion
January 30, 2023
Study Completion
January 30, 2023
Last Updated
May 5, 2022
Record last verified: 2022-05