Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography
1 other identifier
observational
20
0 countries
N/A
Brief Summary
Investigators' research is concerned observing the post-operative anterior segment OCT changes throughout the post- operative follow up of the patient and relating to improve the visual outcome of the surgery which is the goal of surgery
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started May 2022
Typical duration for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 29, 2022
CompletedFirst Posted
Study publicly available on registry
April 26, 2022
CompletedStudy Start
First participant enrolled
May 1, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 29, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
September 29, 2024
CompletedApril 26, 2022
April 1, 2022
1.9 years
March 29, 2022
April 19, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
To evaluate the post-operative changes after DALK surgery through ant segment OCT and its relation to clinical findings.
To evaluate the post-operative changes after DALK surgery through ant segment OCT and its relation to clinical findings.
6 months after the surgery
Secondary Outcomes (1)
To Improve sugery
6 months after the surgery
Interventions
DALK is a partial-thickness corneal transplant which involves only the donor stroma, leaving the recipient's own Descemet's membrane and endothelium
Eligibility Criteria
Older than 18 years old and younger than 60 in need for dalk
You may qualify if:
- Patients undergoing DALK surgery older than 18 years old ( keratoconus and corneal opacity ).
You may not qualify if:
- Patients suffering from active corneal ulcer
- Active infection.
- Posterior segment diseases.
- Recent ocular surgery in the study eye in the 2 months prior to enrolment,
- Media opacities as vitreous haemorrhage,
- Vasculitis , patients with macular edema related to, glaucoma, chronic uveitis, or pre-existing ocular pathologic features or abnormalities.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (3)
Hos D, Matthaei M, Bock F, Maruyama K, Notara M, Clahsen T, Hou Y, Le VNH, Salabarria AC, Horstmann J, Bachmann BO, Cursiefen C. Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation. Prog Retin Eye Res. 2019 Nov;73:100768. doi: 10.1016/j.preteyeres.2019.07.001. Epub 2019 Jul 3.
PMID: 31279005BACKGROUNDSingh R, Gupta N, Vanathi M, Tandon R. Corneal transplantation in the modern era. Indian J Med Res. 2019 Jul;150(1):7-22. doi: 10.4103/ijmr.IJMR_141_19.
PMID: 31571625BACKGROUNDKrumeich JH, Knulle A, Krumeich BM. [Deep anterior lamellar (DALK) vs. penetrating keratoplasty (PKP): a clinical and statistical analysis]. Klin Monbl Augenheilkd. 2008 Jul;225(7):637-48. doi: 10.1055/s-2008-1027485. German.
PMID: 18642207RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
momen A Mohammad, Lecturer
Assiut University
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 29, 2022
First Posted
April 26, 2022
Study Start
May 1, 2022
Primary Completion
March 29, 2024
Study Completion
September 29, 2024
Last Updated
April 26, 2022
Record last verified: 2022-04
Data Sharing
- IPD Sharing
- Will not share