Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium in Emergency Department

NCT05343702 | Completed

• 1 other identifier: nısık
• Study Type: observational
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Airway management and advanced airway management are the issues that are applied every day in emergency services and that the emergency physician should know best. Rapid sequential intubation is one of the most frequently used techniques in advanced airway management. However, anesthetic agents and paralytic agents have some concerns with some side effects. In our study, This study aimed to compare the effect of standard rapid sequential intubation protocol and application of rocuronium priming technique on the procedure time and hemodynamic profile.

Conditions

Rapid Sequence Induction and Intubation; Rocuronium

Keywords

Rapid Sequence Induction and Intubation; Rocuronium

Outcome Measures

Primary Outcomes (3)

• intubation time

  when successful endotracheal intubation is performed after induction

  ten minutes

• blood pressure systolic and diastolic

  mmhg

  ten minutes

• heart rate

  beats/minute

  ten minutes

Secondary Outcomes (1)

• indirect perfusion

  ten minutes

Study Arms (2)

standard

standard rapid sequence intubation group (paralysis following induction)

priming

group primed with rocuronium before induction

Drug: priming with rocuronium

Interventions

priming with rocuronium DRUG

Following induction (paralysis after onset of the induction effect) in routine rapid sequence intubation protocols While paralysis is applied, it is aimed to shorten the half-life of rocuronium by administering a subparalytic dose of rocuronium approximately 3-5 minutes before induction in the priming technique

priming

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Our study is a prospective, observational and randomized study conducted between 15.07.2021 and 01.12.2021 in Ankara City Hospital Emergency Medicine Clinic, which is a third-level emergency department with approximately 450,000 patient admissions per year. Patients who applied to the emergency department and needed rapid sequential intubation were included in our study.

You may qualify if:

• Be over the age of 18
• Need for advanced airway
• To give consent or consent to participate in the study consent of relatives of those who are unable to give

You may not qualify if:

• Have an indication of a crush (rescue) airway
• Have one of the difficult airway predictor Look, Evaluate, Obstruction, Neck mobility criteria
• maxillofacial anomaly or trauma
• detected during laryngoscopy with a cormack-lehane score of 3 and 4 patients
• Those who have inconveniences in applying ketamine to the clinic of the patient
• with a rocuronium or ketamine allergy

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent Şehir Hastanesi

Ankara, 0600, Turkey (Türkiye)

Location

Related Publications (1)

• Isik NI, Ozhasenekler A, Yildirim C, Sener A, Kahraman FA, Gunaydin GP. Comparison of rocuronium priming vs. standard rapid sequence intubation technique in emergency department patients requiring intubation. Rev Assoc Med Bras (1992). 2024 Apr 22;70(3):e20231029. doi: 10.1590/1806-9282.20231029. eCollection 2024.

  PMID: 38655998 DERIVED

MeSH Terms

Interventions

Rocuronium

Intervention Hierarchy (Ancestors)

Androstanols; Androstanes; Steroids; Fused-Ring Compounds; Polycyclic Compounds

Study Officials

• NURULLAH İSHAK IŞIK, M.D.

  Ankara City Hospital Bilkent

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: emergency medicine specialist

Study Record Dates

• First Submitted: April 8, 2022
• First Posted: April 25, 2022
• Study Start: July 15, 2021
• Primary Completion: December 1, 2021
• Study Completion: January 15, 2022
• Last Updated: September 28, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP

Locations

TU (1)