Relationship Between Effect Duration of Rocuronium and Body Composition Analysis Data.

NCT05515835 | Unknown

• 1 other identifier: SMC 2022-07-160
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

The induction dose of rocuronium is typically decided based on the patient's body weight, but the effect duration of rocuronium is variable. Some studies suggest that body composition analysis data, such as skeletal muscle mass or total body water, may correlate better with the duration time of rocuronium. Therefore, we plan to analyse body composition in patients undergoing total intravenous general anesthesia, give the patients a fixed dose (50mg) of rocuronium, and check the correlation between duration time of rocuronium and body composition analysis data.

Conditions

Rocuronium; Body Composition

Outcome Measures

Primary Outcomes (2)

• time to TOF1

  correlation between the time from induction to recovery of 1st TOF twitch and age, sex, ASA class, body weight, and body composition analysis data

  up to 1 hour after rocuronium administration during induction of anesthesia

• time to TOF4

  correlation between the time from induction to recovery of 4th TOF twitch and age, sex, ASA class, body weight, and body composition analysis data

  up to 1.5 hour after rocuronium administration during induction of anesthesia

Secondary Outcomes (1)

• time to loss of TOF

  up to 5 minutes after rocuronium administration during induction of anesthesia

Study Arms (1)

rocuronium

The patient will be given 50mg of rocuronium intravenously for induction.

Device: body composition analysis

Interventions

body composition analysis DEVICE

Patients will undergo body composition analysis using bioelectical impedance method before anesthesia.

rocuronium

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with ASA class I-II undergoing total intravenous general anesthesia

You may qualify if:

• Adult patients with ASA class I-II undergoing total intravenous general anesthesia

You may not qualify if:

• too overweight (over 111.11kg, which corresponds to less than 0.45mg/kg of induction dose of rocuronium)
• too underweight (under 41.67kg, which corresponds to more than 1.2mg/kg of induction dose of rocuronium)
• pregnancy
• prediagnosed muscle or nerve related disease
• unsuitable for body composition analysis using bioelectrical impedance method
• unsuitable for neuromuscular block monitoring

Sponsors & Collaborators

• Samsung Medical Center: lead

Study Sites (1)

Samsung Medical Center, Sungkyunkwan University, School of Medicine

Seoul, 06351, South Korea

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.

Study Record Dates

• First Submitted: August 22, 2022
• First Posted: August 25, 2022
• Study Start: September 5, 2022
• Primary Completion: December 30, 2022
• Study Completion: March 1, 2023
• Last Updated: January 4, 2023

Record last verified: 2023-01

Locations

KR (1)