Fitness and Fat Oxidation in Overweight Chinese, Indian and Malay Men

NCT05337111 | Completed DMC

• 1 other identifier: 2017-T1-002-036
• Study Type: observational
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

South Asian men have lower cardiorespiratory fitness (CRF) than white men which is associated with a reduced capacity to oxidise fat during exercise. This is a risk factor for weight gain/regain. Whilst comparisons with Europeans are valuable, Asians are not a homogenous group and substantial differences in obesity and body fat partitioning exist with ethnicity. This cross-sectional pilot investigation aims to compare CRF and fat oxidation at rest and during exercise in Chinese, Indian and Malay men (from Singapore) with elevated BMI (23 -30 kg/m2). Forty-five men (15 each ethnicity) with elevated body mass index (23 -30 kg/m2) will complete testing in a fasted state on two separate mornings separated by ≥72 hours: (i) for a measure of CRF; and (ii) for a measure of fat oxidation at rest and during incremental exercise.

Conditions

Overweight and Obesity

Outcome Measures

Primary Outcomes (3)

• Cardiorespiratory fitness

  Predicted measure of maximum oxygen uptake during exercise

  1 day (Single measurement)

• Resting fat oxidation

  Measure of amount of fat oxidised whilst at rest in the postabsorptive (fasting) state

  1 day (Single measurement)

• Maximum fat oxidation (exercise)

  Measure of maximum amount of fat oxidised whilst exercising in the postabsorptive state

  1 day (Single measurement)

Study Arms (3)

Chinese men

Chinese men based on self-identity for three generations (parents and grandparents), age 25 - \<45 years, who are physically inactive (\< 150 minutes moderate or \< 75 minutes vigorous leisure-time physical activity per week), with elevated body mass index (\>23-\<30 kg/m2) for Asians. Single measure of CRF, resting fat oxidation and fat oxidation during graded exercise.

Other: Cardiorespiratory fitness test; Other: Resting measure of fat oxidation; Other: Maximum fat oxidation test

Indian men

Indian men based on self-identity for three generations (parents and grandparents), age 25 - \<45 years, who are physically inactive (\< 150 minutes moderate or \< 75 minutes vigorous leisure-time physical activity per week), with elevated body mass index (\>23-\<30 kg/m2) for Asians. Single measure of CRF, resting fat oxidation and fat oxidation during graded exercise.

Other: Cardiorespiratory fitness test; Other: Resting measure of fat oxidation; Other: Maximum fat oxidation test

Malay men

Malay men based on self-identity for three generations (parents and grandparents), age 25 - \<45 years, who are physically inactive (\< 150 minutes moderate or \< 75 minutes vigorous leisure-time physical activity per week), with elevated body mass index (\>23-\<30 kg/m2) for Asians. Single measure of CRF, resting fat oxidation and fat oxidation during graded exercise.

Other: Cardiorespiratory fitness test; Other: Resting measure of fat oxidation; Other: Maximum fat oxidation test

Interventions

Cardiorespiratory fitness test OTHER

Progressive submaximal exercise test on a treadmill to predict cardiorespiratory fitness

Also known as: Graded exercise test, submaximal oxygen uptake test

Chinese men; Indian men; Malay men

Resting measure of fat oxidation OTHER

Use of ventilated hood attached to automated metabolic cart to measure substrate oxidation at rest

Also known as: Resting energy expenditure, resting substrate oxidation test

Chinese men; Indian men; Malay men

Maximum fat oxidation test OTHER

Progressive exercise test to determine maximum fat oxidation during exercise

Chinese men; Indian men; Malay men

Eligibility Criteria

• Age: 21 Years - 45 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy but physically inactive Chinese, Indian and Malay men aged 21-45 years with an elevated body mass index for Asians.

You may qualify if:

• male
• age 25 - \<45 years
• Chinese, Indian or Malay based on self-identity for three generations (parents and grandparents)
• BMI ≥ 23 - \< 30 kg/m2 and/or waist circumference ≥ 90 cm
• physically inactive defined as \< 150 minutes moderate or \< 75 minutes vigorous leisure-time physical activity per week, or the equivalent combination of both

You may not qualify if:

• females
• personal history of cardio-metabolic diseases
• dieting (i.e. restricting food/energy intake)
• smokers
• consuming alcohol \> 3 times per week with \> 3 drinks per time
• using any medications which affect carbohydrate or lipid metabolism
• any lower body injuries
• fasting blood glucose \> 6.1 mmol/L

Sponsors & Collaborators

• Nanyang Technological University: lead
• Ministry of Education, Singapore: collaborator

Study Sites (1)

Human Bioenergetics Laboratory, National Institute of Education, Nanyang Technological University

Singapore, 637616, Singapore

Location

Related Publications (1)

• Demashkieh M, Dalan R, Burns SF. Cardiorespiratory fitness and fat oxidation during exercise in Chinese, Indian, and Malay men with elevated body mass index. Appl Physiol Nutr Metab. 2022 Aug 1;47(8):888-892. doi: 10.1139/apnm-2022-0106. Epub 2022 Jun 9.

  PMID: 35679614 DERIVED

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Stephen F Burns, PhD

  Nanyang Technological University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 14, 2022
• First Posted: April 20, 2022
• Study Start: July 1, 2019
• Primary Completion: March 30, 2020
• Study Completion: July 31, 2020
• Last Updated: April 20, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)