High Intensity Interval Circuit Training on Resting Metabolic Rate in Overweight Adults

NCT03972059 | Completed

• 1 other identifier: HIICT-RMR study
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This is the first study to examine changes in resting metabolic rate up to 72 hours following an exercise session, and how these changes may be affected by 12 weeks of high intensity interval circuit training (HIICT). Various training programs that have been implemented in previous studies have investigated changes in resting metabolic rate only for the first 2-8 hours following an exercise session. Briefly, the results of this study will provide insight into the following:

1. 1.To what extent and for how long does HIICT increases the resting metabolic rate following an exercise session?
2. 2.How can this exercise program enhance metabolism without any dietary or other exercise intervention?
3. 3.What is the caloric deficit that will result from 3 months of HIICT and how to what extent this deficit will influence body weight reduction?

Conditions

Overweight and Obesity

Outcome Measures

Primary Outcomes (8)

• Resting metabolic rate (kilocalories)

  Resting metabolic rate following 12 hours of an overnight fast

  At baseline

• Resting metabolic rate (24 before an exercise bout) (kilocalories)

  Changes in resting metabolic rate 24 before an exercise bout

  Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Resting metabolic rate (24 following an exercise bout) (kilocalories)

  Changes in resting metabolic rate 24 following an exercise bout

  Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Resting metabolic rate (48 following an exercise bout) (kilocalories)

  Changes in resting metabolic rate 48 following an exercise bout

  Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Resting metabolic rate (72 following an exercise bout) (kilocalories)

  Changes in resting metabolic rate 72 following an exercise bout

  Pre-intervention, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Body fat mass (kilograms)

  Changes in body fat mass measured with dual-energy x-ray absorptiometry (DEXA)

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Body lean mass (kilograms)

  Changes in body lean mass measured with dual-energy x-ray absorptiometry (DEXA)

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Bone mass (kilograms)

  Changes in bone mass measured with dual-energy x-ray absorptiometry (DEXA)

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

Secondary Outcomes (5)

• Waist to hip ratio (WHR)

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Lower limb strength

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Upper body strength

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Aerobic capacity test

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

• Maximal abdominal muscle endurance

  At baseline, 24 hours after completion of phase 1, 24 hours after completion of phase 2, 24 hours after completion of phase 3

Study Arms (2)

Experimental group

EXPERIMENTAL

A 12-week high intensity interval circuit training program for weight management in overweight adults.

Other: Exercise training - Phase 1; Other: Exercise training - Phase 2; Other: Exercise training - Phase 3

Control group

NO INTERVENTION

No intervention for 12 weeks, participants perform all tests.

Interventions

Exercise training - Phase 1 OTHER

Phase 1 is the first 4 weeks of the 12-week training program.

Experimental group

Exercise training - Phase 2 OTHER

Phase 2 is the next 4 weeks following phase 1 of the 12-week training program. The exercise intensity during exercise bouts in this phase is increased compared to the exercise intensity applied in phase 1.

Experimental group

Exercise training - Phase 3 OTHER

Phase 3 is the last 4 weeks of the 12-week training program. The exercise intensity during exercise bouts in this phase is increased compared to the exercise intensity applied in the previous phases.

Experimental group

Eligibility Criteria

• Age: 30 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Overweight or class I obesity (BMI: 25-35 kg/m\^2)
• Sedentary lifestyle
• Willing to lose weight
• Individuals at low risk of various cardiovascular, pulmonary, renal, and metabolic diseases as well as other conditions (e.g., pregnancy and orthopedic injury) that require special attention when developing the exercise prescription (Thompson et al., 2013). This risk classification indicates that participants will be able to participate in moderate intensity exercise \[40-60% oxygen uptake reserve (VO2R); 3-6 metabolic equivalent of task (METs)\] and also in vigorous intensity exercise (\>60% VO2R; \>6 METs) while medical examination, exercise test and physician supervision are not recommended in the preparticipation health screening process.

You may not qualify if:

• Following a diet plan or taking dietary supplements over the last 6 months and during the intervention
• Participation in another training program over the last 6 months and during the intervention
• Family history of coronary heart disease
• Recent musculoskeletal injury

Sponsors & Collaborators

• University of Thessaly: lead

Study Sites (1)

SmArT LABORATORY, SCHOOL OF PHYSICAL EDUCATION & SPORTS SCIENCES, UNIVERSITY OF THESSALY

Trikala, 42100, Greece

Location

MeSH Terms

Conditions

Overweight; Obesity

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Ioannis G Fatouros, PhD

  SmArT Lab, DPESS, University of Thessaly

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: The 12-week training program will be divided into 3 phases (4 weeks each phase). Completion of each phase means that the subjects have increased their physical fitness and will get to the next phase where the intensity of exercise will increase in order to gain more physical fitness benefits (e.g. increased caloric expenditure). There will be a control group as well, where participants will not participate in any intervention.

Study Record Dates

• First Submitted: May 23, 2019
• First Posted: June 3, 2019
• Study Start: April 8, 2019
• Primary Completion: July 20, 2019
• Study Completion: August 20, 2019
• Last Updated: November 6, 2019

Record last verified: 2019-11

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)