Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

NCT05334355 | Completed Results

• 1 other identifier: IRB-FY15-16-185 & 19-20-1602
• Study Type: observational
• Target: 74
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.

Conditions

Genetic Predisposition; Genetic Hypertension

Outcome Measures

Primary Outcomes (1)

• Left Ventricular Mass

  Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound.

  Day 2

Study Arms (2)

Positive Family History of Hypertension

Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension.

Other: Family history of hypertension

Negative Family History of Hypertension

Young normotensive generally healthy adult with no biological parent with diagnosed hypertension.

Interventions

Family history of hypertension OTHER

Presence or absence of a family history of hypertension in a cross sectional study design.

Positive Family History of Hypertension

Eligibility Criteria

• Age: 18 Years - 32 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Young healthy normotensive adults who are capable of self reporting family history of hypertension.

You may qualify if:

• Generally healthy

You may not qualify if:

• Known hypertension, cardiovascular disease, current pregnancy, current infectious disease, diabetes mellitus, kidney disease, a history of cancer, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions

Sponsors & Collaborators

• Montclair State University: lead

Related Publications (1)

• Callaghan KN, Hosick PA, Brian MS, Matthews EL. Impact of a family history of hypertension and physical activity on left ventricular mass. J Sports Med Phys Fitness. 2023 Aug;63(8):949-956. doi: 10.23736/S0022-4707.23.14877-8. Epub 2023 May 9.

  PMID: 37158799 RESULT

MeSH Terms

Conditions

Genetic Predisposition to Disease

Condition Hierarchy (Ancestors)

Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Results Point of Contact

• Title: Dr. Evan Matthews, Associate Professor
• Organization: Montclair State University

matthewse@montclair.edu

9736553948

Study Officials

• Evan L Matthews, PhD

  Montclair State University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 1, 2022
• First Posted: April 19, 2022
• Study Start: April 19, 2016
• Primary Completion: February 27, 2020
• Study Completion: February 27, 2020
• Last Updated: February 24, 2025
• Results First Posted: February 24, 2025

Record last verified: 2025-02

Data Sharing

• IPD Sharing: Will share
• Time Frame: The data is currently available with no expiration date.
• Access Criteria: Publicly available