Research for Associated Genes for Gastric Cancer in Family Member With Affected First-Degree Relatives
1 other identifier
observational
105
1 country
1
Brief Summary
Familial gastric cancer accounts for 10% of all cases, but predisposing genetic variations is unknown except for CDH1 mutation. Because Germline mutation is believed to be a key aspect of cancer predisposition, we plan to recruit persons with 2 or more affected family members in three-generation pedigree. The investigators will perform a whole-exome sequencing using DNA from blood samples of families including gastric cancer patients and non-gastric cancer patients
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2016
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 7, 2016
CompletedFirst Submitted
Initial submission to the registry
March 24, 2018
CompletedFirst Posted
Study publicly available on registry
April 3, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2022
CompletedApril 18, 2023
April 1, 2023
5.6 years
March 24, 2018
April 16, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
Genes with logarithm of odds (LOD)>2 in linkage analysis
Based on LOD at baseline, candidate genes will be selected.
0 day (baseline)
Study Arms (2)
Gastric cancer
Pathologically proven diseases after upper gastroendoscopy and biopsy. Previous pathological reports and endoscopic image can be used.
non-gastric cnacer
Rull out gastric cancer by upper gastroendoscopy. The results 3 moths before enrollment is available.
Interventions
Presence/absence of gastric cancer will be evaluated by upper gastroendoscopy or results of pathological test
Eligibility Criteria
The investigator will recruit or invite the participants among persons who visit the clinic with a family history of gastric cancer. The investigator plans to recruit gastric cancer patients and non-patients in family with 2 or more affected members. Non-gastric cancer patients was restricted to persons over 50 years of age.
You may qualify if:
- Gastric cancer patients and their first-degree relatives
- Members in family with two or more gastric cancer patients within three- generation pedigree
You may not qualify if:
- Those who reject the enrollment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 463-707, South Korea
Biospecimen
DNA from 10ml of plasma
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- FAMILY BASED
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
March 24, 2018
First Posted
April 3, 2018
Study Start
December 7, 2016
Primary Completion
July 31, 2022
Study Completion
December 31, 2022
Last Updated
April 18, 2023
Record last verified: 2023-04