Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.

NCT05330637 | Unknown

• 1 other identifier: SYFYIRB2022009
• Study Type: observational
• Target: 800
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.

Conditions

Asthma; Allergic Rhinitis; Chronic Obstructive Pulmonary Disease(COPD); Atopic Dermatitis; Eczema; Urticaria; Bronchitis; Bronchiectasis Adult; Emphysema

Keywords

Asthma; Allergic Rhinitis; Climatotherapy; Chronic Obstructive Pulmonary Disease(COPD); Atopic Dermatitis; Climate; Environment

Outcome Measures

Primary Outcomes (1)

• The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China.

  The asthma, COPD, allergic rhinitis or atopic dermatitis will be diagnosed and assessed through history of diseases and questionnaire..

  3 year

Secondary Outcomes (7)

• Asthma control of migratory old people with asthma.

  1-3 year

• Asthma life quality of migratory old people with asthma.

  1-3 year

• Lung function of migratory old people with asthma or COPD.

  1-3 year

• The respiratory function of migratory old people with COPD.

  1-3 year

• Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.

  1-3 year

Study Arms (11)

Migratory old people with asthma from northern China in Sanya

Migratory old people with asthma from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Other: Climate and environment in Sanya

Migratory old people with allergic rhinitis from northern China in Sanya

Migratory old people with allergic rhinitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Other: Climate and environment in Sanya

Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya

Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Other: Climate and environment in Sanya

Migratory old people with atopic dermatitis from northern China in Sanya

Migratory old people with atopic dermatitis from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Other: Climate and environment in Sanya

Children with asthma in Sanya

Children with asthma have being exposure to tropical climate and environment in Sanya for years.

Other: Climate and environment in Sanya

Children with allergic rhinitis in Sanya

Children with allergic rhinitis have being exposure to tropical climate and environment in Sanya for years.

Other: Climate and environment in Sanya

Children with atopic dermatitis in Sanya

Children with atopic dermatitis have being exposure to tropical climate and environment in Sanya for years.

Other: Climate and environment in Sanya

Children with eczema in Sanya

Children with eczema have being exposure to tropical climate and environment in Sanya for years.

Other: Climate and environment in Sanya

Children with urticaria in Sanya

Children with urticaria have being exposure to tropical climate and environment in Sanya for years.

Other: Climate and environment in Sanya

Migratory old people with eczema from northern China in Sanya

Migratory old people with eczema from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Other: Climate and environment in Sanya

Migratory old people with urticaria from northern China in Sanya

Migratory old people with urticaria from northern China to Sanya have being exposure to two different climate and environment from northern China to Sanya for months.

Other: Climate and environment in Sanya

Interventions

Climate and environment in Sanya OTHER

Sanya have unique island climate and environment campared with the north of China, with a feature of warm, moist and long-sunshine.

Children with allergic rhinitis in Sanya; Children with asthma in Sanya; Children with atopic dermatitis in Sanya; Children with eczema in Sanya; Children with urticaria in Sanya; Migratory old people with Chronic Obstructive Pulmonary Disease (COPD) from northern China in Sanya; Migratory old people with allergic rhinitis from northern China in Sanya; Migratory old people with asthma from northern China in Sanya; Migratory old people with atopic dermatitis from northern China in Sanya; Migratory old people with eczema from northern China in Sanya; Migratory old people with urticaria from northern China in Sanya

Eligibility Criteria

• Age: 3 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

1. 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atypical dermatitis from northeast China. 2. 3-12 years-old children with asthma, allergic rhinitis, atypical dermatitisin in Sanya.

You may qualify if:

• years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
• years-old children in Sanya;
• Agree to participate this study.

You may not qualify if:

• Disagree to participate this study;
• Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
• Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.

Sponsors & Collaborators

• Shanghai Jiao Tong University School of Medicine: lead

Study Sites (1)

Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University

Sanya, Hainan, China

RECRUITING

Related Publications (14)

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• Xie L, Liu Z, Hao S, Wu Q, Sun L, Luo H, Yu R, Li X, Wu X, Li S. Assessment of knowledge, attitude, and practice towards pulmonary rehabilitation among COPD patients: A multicenter and cross-sectional survey in China. Respir Med. 2020 Nov-Dec;174:106198. doi: 10.1016/j.rmed.2020.106198. Epub 2020 Oct 20.

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  PMID: 29731623 RESULT

• Ding Y, Xu J, Yao J, Chen Y, He P, Ouyang Y, Niu H, Tian Z, Sun P. The analyses of risk factors for COPD in the Li ethnic group in Hainan, People's Republic of China. Int J Chron Obstruct Pulmon Dis. 2015 Nov 30;10:2593-600. doi: 10.2147/COPD.S86402. eCollection 2015.

  PMID: 26664107 RESULT

• Garcia-Almaraz R, Reyes-Noriega N, Del-Rio-Navarro BE, Berber A, Navarrete-Rodriguez EM, Ellwood P, Garcia Marcos Alvarez L; GAN Phase I group. Prevalence and risk factors associated with allergic rhinitis in Mexican school children: Global Asthma Network Phase I. World Allergy Organ J. 2020 Dec 5;14(1):100492. doi: 10.1016/j.waojou.2020.100492. eCollection 2021 Jan.

  PMID: 34659624 RESULT

• Pesce G, Bugiani M, Marcon A, Marchetti P, Carosso A, Accordini S, Antonicelli L, Cogliani E, Pirina P, Pocetta G, Spinelli F, Villani S, de Marco R. Geo-climatic heterogeneity in self-reported asthma, allergic rhinitis and chronic bronchitis in Italy. Sci Total Environ. 2016 Feb 15;544:645-52. doi: 10.1016/j.scitotenv.2015.12.015. Epub 2015 Dec 10.

  PMID: 26674694 RESULT

• Zanolin ME, Pattaro C, Corsico A, Bugiani M, Carrozzi L, Casali L, Dallari R, Ferrari M, Marinoni A, Migliore E, Olivieri M, Pirina P, Verlato G, Villani S, Marco R; ISAYA Study Group. The role of climate on the geographic variability of asthma, allergic rhinitis and respiratory symptoms: results from the Italian study of asthma in young adults. Allergy. 2004 Mar;59(3):306-14. doi: 10.1046/j.1398-9995.2003.00391.x.

  PMID: 14982513 RESULT

• Weiland SK, Husing A, Strachan DP, Rzehak P, Pearce N; ISAAC Phase One Study Group. Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med. 2004 Jul;61(7):609-15. doi: 10.1136/oem.2002.006809.

  PMID: 15208377 RESULT

• Wang X, Zhuang Y, Chen Y, Wang H, Wang X. Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China. Allergy Asthma Clin Immunol. 2021 Mar 9;17(1):27. doi: 10.1186/s13223-021-00532-7.

  PMID: 33750462 RESULT

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• Li J, Sun B, Huang Y, Lin X, Zhao D, Tan G, Wu J, Zhao H, Cao L, Zhong N; China Alliance of Research on Respiratory Allergic Disease. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China. Allergy. 2009 Jul;64(7):1083-92. doi: 10.1111/j.1398-9995.2009.01967.x. Epub 2009 Feb 11.

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• Donaldson GC, Wedzicha JA. The causes and consequences of seasonal variation in COPD exacerbations. Int J Chron Obstruct Pulmon Dis. 2014 Oct 6;9:1101-10. doi: 10.2147/COPD.S54475. eCollection 2014.

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• Kantor R, Silverberg JI. Environmental risk factors and their role in the management of atopic dermatitis. Expert Rev Clin Immunol. 2017 Jan;13(1):15-26. doi: 10.1080/1744666X.2016.1212660. Epub 2016 Jul 28.

  PMID: 27417220 RESULT

• Wang X, Li LF, Zhao DY, Shen YW. Prevalence and Clinical Features of Atopic Dermatitis in China. Biomed Res Int. 2016;2016:2568301. doi: 10.1155/2016/2568301. Epub 2016 Nov 13.

  PMID: 27957490 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Veinal blood

MeSH Terms

Conditions

Asthma; Rhinitis, Allergic; Pulmonary Disease, Chronic Obstructive; Dermatitis, Atopic; Eczema; Urticaria; Bronchitis; Emphysema

Interventions

Climate; Environment

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Rhinitis; Nose Diseases; Otorhinolaryngologic Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Skin Diseases, Vascular; Respiratory Tract Infections; Infections

Intervention Hierarchy (Ancestors)

Ecological and Environmental Phenomena; Biological Phenomena; Atmosphere; Meteorological Concepts; Environment and Public Health

Study Officials

• Shijian Liu, Ph.D

  Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shijian Liu, Ph.D

CONTACT

86-21-38087983; liushijian@scmc.com.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 18, 2022
• First Posted: April 15, 2022
• Study Start: March 3, 2022
• Primary Completion: December 31, 2023
• Study Completion: April 30, 2025
• Last Updated: September 11, 2023

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)