Causal Associations Between Allergic Rhinitis and Asthma

NCT06668974 | Completed

• 1 other identifier: GS-002
• Study Type: observational
• Target: 239,607
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the causal relationship between allergic rhinitis and asthma using a bidirectional two-sample Mendelian randomization approach. Genetic data were derived from UK Biobank for allergic rhinitis and from Finnish biobank for asthma. This analysis aims to clarify the potential causal link between these two conditions.

Conditions

Allergic Rhinitis; Asthma

Keywords

Mendelian Randomization; Genetic Association; Bidirectional Causality; Genome-Wide Association Study (GWAS); Respiratory Diseases

Outcome Measures

Primary Outcomes (2)

• Causal Effect of Allergic Rhinitis on Asthma Risk

  Estimate the causal effect of allergic rhinitis on asthma risk using bidirectional Mendelian randomization. This measure includes odds ratios (OR) derived from inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods.

  Oct 24 2024

• Causal Effect of Asthma on Allergic Rhinitis Risk

  Estimate the causal effect of asthma on allergic rhinitis risk using bidirectional Mendelian randomization. This measure includes odds ratios (OR) derived from inverse-variance weighting (IVW), Mendelian randomization-Egger (MR-Egger), and weighted median methods.

  Oct 24 2024

Secondary Outcomes (3)

• Sensitivity Analysis Using MR-Egger Intercept Test

  Oct 24 2024

• Sensitivity Analysis Using Leave-One-Out Test

  Oct 24 2024

• Sensitivity Analysis Using MR-PRESSO

  Oct 24 2024

Study Arms (2)

Allergic Rhinitis Cohort

This cohort consists of individuals with allergic rhinitis and a control group from the UK Biobank database, including 18,934 cases of allergic rhinitis and 64,595 controls. Genetic data were used to explore causal relationships with asthma.

Other: Mendelian Randomization

Asthma Cohort

This cohort includes individuals with asthma and a control group from the Finnish biobank database, consisting of 20,629 cases of asthma and 135,449 controls. Genetic data were analyzed to examine causal associations with allergic rhinitis.

Other: Mendelian Randomization

Interventions

Mendelian Randomization OTHER

This study utilizes a bidirectional Mendelian randomization approach to analyze genetic data from individuals with allergic rhinitis and asthma. No active intervention is applied; genetic variants serve as instrumental variables to assess causal associations between the conditions.

Allergic Rhinitis Cohort; Asthma Cohort

Eligibility Criteria

• Age: 0 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes individuals diagnosed with allergic rhinitis or asthma from the UK Biobank and Finnish biobank databases.

You may qualify if:

• Individuals diagnosed with allergic rhinitis or asthma.
• Availability of genetic data in the UK Biobank or Finnish biobank.

You may not qualify if:

• Individuals without genetic data.
• Participants with incomplete phenotype or genotype data.

Sponsors & Collaborators

• Zhibin Xu: lead

Study Sites (1)

Guangzhou Institute of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510120, China

Location

MeSH Terms

Conditions

Rhinitis, Allergic; Asthma; Respiratory Tract Diseases

Interventions

Mendelian Randomization Analysis

Condition Hierarchy (Ancestors)

Rhinitis; Nose Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Bronchial Diseases; Lung Diseases, Obstructive; Lung Diseases

Intervention Hierarchy (Ancestors)

Molecular Epidemiology; Epidemiologic Methods; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 30, 2024
• First Posted: November 1, 2024
• Study Start: October 1, 2024
• Primary Completion: October 15, 2024
• Study Completion: October 28, 2024
• Last Updated: November 1, 2024

Record last verified: 2024-10

Locations

CN (1)