NCT05327543

Brief Summary

This study investigates the effects of two different online yoga interventions on the health-related quality of life in breast cancer patients. Qualitative and quantitative data will be collected.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
138

participants targeted

Target at P50-P75 for not_applicable

Timeline
7mo left

Started May 2022

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress88%
May 2022Dec 2026

First Submitted

Initial submission to the registry

April 7, 2022

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 14, 2022

Completed
25 days until next milestone

Study Start

First participant enrolled

May 9, 2022

Completed
4.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2026

Expected
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2026

Last Updated

February 18, 2025

Status Verified

February 1, 2025

Enrollment Period

4.1 years

First QC Date

April 7, 2022

Last Update Submit

February 14, 2025

Conditions

Keywords

Yoga

Outcome Measures

Primary Outcomes (1)

  • Functional Assessment of Cancer Therapy - Breast Cancer (FACT-B)

    Assessing full scale, range 0-40, higher score meaning a better outcome

    Date of inclusion (baseline), after 8 weeks

Secondary Outcomes (17)

  • Functional Assessment of Cancer Therapy - Breast Cancer (FACT-B)

    Date of inclusion (baseline), after 8 weeks, after 16 weeks, after 24 weeks

  • Functional Assessment of Cancer Therapy: Fatigue (FACIT-F)

    Date of inclusion (baseline), after 8 weeks, after 16 weeks, after 24 weeks

  • Perceived Stress Scale (PSS-10)

    Date of inclusion (baseline), after 8 weeks, after 16 weeks, after 24 weeks

  • Flourishing Scale (FS-D)

    Date of inclusion (baseline), after 8 weeks, after 16 weeks, after 24 weeks

  • Self-Compassion Scale (SCS-D)

    Date of inclusion (baseline), after 8 weeks, after 16 weeks, after 24 weeks

  • +12 more secondary outcomes

Other Outcomes (2)

  • Qualitative interviews

    8 weeks after inclusion

  • Heart Rate Variability (HRV)

    Date of inclusion (baseline), after 8 weeks

Study Arms (3)

Iyengar yoga

EXPERIMENTAL

Intervention group 1 receives an Iyengar yoga intervention online in a group setting, based on the internationally renowned yoga school of B.K.S. Iyengar, which in the context of this study primarily includes physical and relaxation exercises.

Behavioral: Iyengar Yoga

Meditative yoga

EXPERIMENTAL

Intervention group 2 receives an Integrative yoga intervention online including physical and meditation exercises as well as ideologically neutral explanations of the ethical aspects of Yoga.

Behavioral: Meditative Yoga

Waitlist Control Group

NO INTERVENTION

Group 3 consists of a waitlist control group. Participants will be offered the opportunity to attend a yoga intervention after 4 months. The patients in this waiting list control group are allowed to choose the yoga course after 4 months.

Interventions

Iyengar YogaBEHAVIORAL

Iyengar Yoga focuses on the correct alignment of the body while practicing the physical exercises of yoga. Props are used to support the body in finding the right alignment. Relaxation is also part of this intervention. Participiants receive 1x90 min guided yoga class per week for 8 weeks and are encouraged to continue their practice at home daily for at least 30 minutes.

Iyengar yoga
Meditative YogaBEHAVIORAL

Meditative Yoga in the context of this study means practicing the physical exercises of yoga as well as meditation. Additionally, each week one of the yamas/niyamas, which are ethical principles to live by in the Yoga philosophy, will be presented at the beginning of each class and will form the theme of the class. Participants receive 1x90 min guided yoga class per week for 8 weeks and are encouraged to continue their practice at home daily for at least 30 minutes.

Meditative yoga

Eligibility Criteria

Age18 Years - 75 Years
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Histologically confirmed diagnosis of non-metastatic breast cancer (TNM stage I-III) up to 5 years after diagnosis
  • Primary therapy completed for at least 3 months
  • Limitation of the quality of life due to the cancer (indication of at least 4 out of 10 points on the numerical analogue scale)
  • Willingness to participate in the study and signed informed consent.

You may not qualify if:

  • Current or planned chemotherapy, radiation or surgery
  • Severe physical or psychopharmacologically treated psychiatric comorbidity due to which a patient is unable to participate in the study
  • Pregnancy/breastfeeding
  • Participation in other clinical trials with behavioral, psychological, or complementary medicine interventions
  • Immobility or limitation for gymnastic exercise due to orthopedic, neurologic, or other medical cause
  • regular meditation practice \>2x/month
  • regular yoga practice \>2x/month

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Charite University

Berlin, State of Berlin, 14109, Germany

RECRUITING

MeSH Terms

Conditions

Breast NeoplasmsNeoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Prof. Dr. Andreas Michalsen

Study Record Dates

First Submitted

April 7, 2022

First Posted

April 14, 2022

Study Start

May 9, 2022

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

December 1, 2026

Last Updated

February 18, 2025

Record last verified: 2025-02

Locations