Implementation of a Depression Screening Intervention at a Transgender Health Clinic in Thailand

NCT05323695 | Completed

• 2 other identifiers: IHRI008D43TW011302
• Study Type: interventional
• Target: 317
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to develop and implement a depression screening intervention into routine HIV and sexual health service provision at a transgender health clinic in Thailand, and to explore the facilitators, barriers, feasibility and acceptability of the screening implementation.

Conditions

Depressive Symptoms

Keywords

Depression; Transgender women

Outcome Measures

Primary Outcomes (7)

• Intervention Acceptability: Number of participants who accepted intervention

  Acceptability will be measured by the number of clients who were offered and accepted the intervention.

  Day 1

• Intervention Acceptability: Participants' perspective of the intervention through in-depth interviews

  Acceptability will be assessed qualitatively through post-intervention in-depth interviews.

  Day 1

• Intervention Acceptability: Participants' perspective of the intervention through focus group discussion

  Acceptability will be assessed qualitatively through post-intervention focus group discussion.

  Day 1

• Intervention Feasibility: Number of intervention completed

  Feasibility will be measured by number of intervention completed. Point estimates of \>50% of participants completed is considered as the minimum criteria for feasibility.

  Day 1

• Intervention Feasibility: Participants' perspective of the intervention through in-depth interviews

  Feasibility will be assessed qualitatively through post-intervention in-depth interviews.

  Day 1

• Intervention Feasibility: Participants' perspective of the intervention through focus group discussion.

  Feasibility will be assessed qualitatively through post-intervention focus group discussion.

  Day 1

• Number of participants screening positive for depression

  Screening positive is defined as scoring 7 or greater on PHQ-9. The total possible score for PHQ-9 is 27, with 0-6 being minimum and indicating no depressive symptoms, 7-12 mild depression, 13-18 moderate depression, and 19-27 severe depression.

  Day 1

Study Arms (1)

Depression Screening Intervention

OTHER

All eligible participants will be screened using the Patient Health Questionnaire-2 (PHQ-2) for depression. If screened positive, participants will be further screened with Patient Health Questionnaire-9 (PHQ-9).

Behavioral: Depression Screening Intervention

Interventions

Depression Screening Intervention BEHAVIORAL

All participants will be screened for depression using PHQ-2 and PHQ-9. Those screened positive for PHQ-2 but decline further screening with PHQ-9 will be assisted for further assessment or care. Those with mild to severe symptoms (score of 7 or higher on PHQ-9) will be assisted for further assessment or care with a psychiatrist.

Depression Screening Intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Thai nationality
• Transgender women ≥18 years
• Attending the Tangerine Clinic for routine care visits during the intervention period.
• Can be a new or returning clients.

You may not qualify if:

• \. Transgender women currently receiving care for a mental health diagnosis will be excluded from participating in this study.
• Currently working at the Tangerine Clinic
• Can be medical doctors, nurses, peer counselors and other members of the clinic management team involved in the routine delivery of HIV and health services to Transgender women.
• \. Not willing to participate in this study

Sponsors & Collaborators

• Thai Red Cross AIDS Research Centre: lead
• amfAR, The Foundation for AIDS Research: collaborator
• National Institutes of Health (NIH): collaborator
• Fogarty International Center of the National Institute of Health: collaborator

Study Sites (1)

Institute of HIV Research and Innovation

Pathum Wan, Bangkok, 10330, Thailand

Location

Related Publications (7)

• Anand T, Nitpolprasert C, Kerr SJ, Muessig KE, Promthong S, Chomchey N, Hightow-Weidman LB, Chaiyahong P, Phanuphak P, Ananworanich J, Phanuphak N. A qualitative study of Thai HIV-positive young men who have sex with men and transgender women demonstrates the need for eHealth interventions to optimize the HIV care continuum. AIDS Care. 2017 Jul;29(7):870-875. doi: 10.1080/09540121.2017.1286288. Epub 2017 Feb 3.

  PMID: 28158952 BACKGROUND

• Schulman JK, Erickson-Schroth L. Mental Health in Sexual Minority and Transgender Women. Med Clin North Am. 2019 Jul;103(4):723-733. doi: 10.1016/j.mcna.2019.02.005.

  PMID: 31078203 BACKGROUND

• Kroenke K, Spitzer RL, Williams JB. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care. 2003 Nov;41(11):1284-92. doi: 10.1097/01.MLR.0000093487.78664.3C.

  PMID: 14583691 BACKGROUND

• Poteat T, Scheim A, Xavier J, Reisner S, Baral S. Global Epidemiology of HIV Infection and Related Syndemics Affecting Transgender People. J Acquir Immune Defic Syndr. 2016 Aug 15;72 Suppl 3(Suppl 3):S210-9. doi: 10.1097/QAI.0000000000001087.

  PMID: 27429185 BACKGROUND

• Rodriguez-Munoz MF, Castelao Legazpi PC, Olivares Crespo ME, Soto Balbuena C, Izquierdo Mendez N, Ferrer Barrientos FJ, Huynh-Nhu L. [PHQ-2 as First Screening Instrument of Prenatal Depression in Primary Health Care, Spain]. Rev Esp Salud Publica. 2017 Jan 30;91:e201701010. Spanish.

  PMID: 28134236 BACKGROUND

• Martinez P, Soto-Brandt G, Brandt S, Guajardo V, Rojas G. [Validation of patient health Questionnaire-2 to detect depressive symptoms in diabetic or hypertensive patients]. Rev Med Chil. 2020 Nov;148(11):1614-1618. doi: 10.4067/S0034-98872020001101614. Spanish.

  PMID: 33844767 BACKGROUND

• Baral S, Logie CH, Grosso A, Wirtz AL, Beyrer C. Modified social ecological model: a tool to guide the assessment of the risks and risk contexts of HIV epidemics. BMC Public Health. 2013 May 17;13:482. doi: 10.1186/1471-2458-13-482.

  PMID: 23679953 BACKGROUND

MeSH Terms

Conditions

Depression

Condition Hierarchy (Ancestors)

Behavioral Symptoms; Behavior

Study Officials

• Rena Janamnuaysook

  Institute of HIV Research and Innovation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 8, 2021
• First Posted: April 12, 2022
• Study Start: October 11, 2021
• Primary Completion: February 15, 2023
• Study Completion: July 2, 2024
• Last Updated: November 26, 2024

Record last verified: 2024-11

Locations

TH (1)