Comparing the Effects of Upper and Lower Body Aerobic Exercise on Pain in Individuals With Chronic Knee Pain

NCT05315934 | Completed

• 1 other identifier: EP 18/19 088
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators want to compare the effects of upper versus lower body moderate aerobic exercise on the experience of pain in individuals with chronic knee pain. Participants will attend the laboratory on 4 separate occasions to complete a series of exercise tests and experimental pain tests.

Conditions

Chronic Knee Pain

Outcome Measures

Primary Outcomes (1)

• Acute Symptomatic Pain

  Change in symptomatic pain measured via Visual Analogue Scale (VAS) from pre- to post-exercise on a 0-10 scale where 0 is no pain at all and 10 is the worst pain imaginable

  Immediately pre and immediately-post exercise

Secondary Outcomes (2)

• Acute Experimental Pain

  Immediately pre and immediately-post exercise

• Follow up Symptomatic Pain

  1-7 days post exercise

Study Arms (2)

Upper Body Aerobic Exercise

EXPERIMENTAL

Participants will perform 30 minutes of arm-crank cycling at a moderate exercise intensity based off the participants perceived RPE13

Other: Upper body aerobic exercise

Lower Body Aerobic Exercise

EXPERIMENTAL

Participants will perform 30 minutes of static cycling at a moderate exercise intensity based off the participants perceived RPE13

Other: Lower body aerobic exercise

Interventions

Upper body aerobic exercise OTHER

Participants will perform 30 minutes of continuous exercise on the arm-crank ergometer.

Upper Body Aerobic Exercise

Lower body aerobic exercise OTHER

Participants will perform 30 minutes of continuous exercise on the cycle ergometer.

Lower Body Aerobic Exercise

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged ≥45 years
• Male or female
• Knee pain for ≥3 months
• Activity related joint pain
• No joint related morning stiffness, or morning stiffness lasting less than 30 minutes.

You may not qualify if:

• Specific joint injury within the last 6 months
• Inability to undertake cycling exercise
• Use of anti-inflammatory medication
• Smoker (or having quit \<6 months ago)
• Osteoarthritis at any upper body sites that would affect ability to complete arm-cycling exercise.

Sponsors & Collaborators

• University of Bath: lead

Study Sites (1)

University of Bath

Bath, BA27AY, United Kingdom

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor James Bilzon

Study Record Dates

• First Submitted: May 17, 2020
• First Posted: April 7, 2022
• Study Start: February 4, 2020
• Primary Completion: January 2, 2022
• Study Completion: January 2, 2022
• Last Updated: July 29, 2022

Record last verified: 2022-07

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)