The Dampness Syndrome of Chinese Medicine Cohort Study

NCT05315895 | Recruiting DMC

• 1 other identifier: SZ2021ZZ06
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 1

Brief Summary

The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.

Conditions

Chronic Disease; Cancer; Dementia Alzheimers; Metabolic Disease; Aging; Alzheimer Disease, Early Onset

Keywords

Dampness Syndrome; multi-center study; prospective cohort study

Outcome Measures

Primary Outcomes (1)

• emerging diseases

  This study will pay attention to the emerging situation of clinical chronic diseases, such as cancer, diabetes, hypertension, coronary heart disease, dementia, etc. Each follow-up the researchers will record the incidence of the emerging diseases of interviewees' by questionnaire including the name of the disease, time of onset and treatments.

  through study completion, an average of 1 year

Secondary Outcomes (18)

• Montreal Cognitive Assessment(MoCA)

  through study completion, an average of 1 year

• European Quality of Life 5-dimensional questionnaire (EQ-5D-5L)

  through study completion, an average of 1 year

• Mini-Mental State Exam (MMSE)

  through study completion, an average of 1 year

• interview questionnaire

  through study completion, an average of 1 year

• change of the blood routine results

  through study completion, an average of 1 year

Study Arms (1)

general population

general population in a specific area and specifc time range.

Other: natural aging process

Interventions

natural aging process OTHER

To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.

general population

Eligibility Criteria

• Age: 35 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

general population in a specific area and specifc time range. Such as civil servants of Guangdong Province. Medical workers in Xinjiang.

You may qualify if:

• Residents aged 30 to 79, whose residence is consistent with their registered permanent residence location;
• Residents who voluntarily participate in the project, agree to the collection of their biological information, and sign the informed consent form;
• Residents who have no mental illness and other related diseases, and display a normal ability of expression and understanding;

You may not qualify if:

• Residents who reject collaboration;
• Residents who allow no follow-up visits.

Sponsors & Collaborators

• Guangzhou University of Traditional Chinese Medicine: lead
• State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine: collaborator

Study Sites (1)

Guangdong Province Hospital of Tradtional Chinese Medicine

Guangzhou, Guangdong, 510120, China

RECRUITING

Related Publications (1)

• Li M, Liu N, Jiang G, Zeng H, Guo J, Wu D, Zhou H, Wen Z, Zhou L. Health-related quality of life in populations with diabetes, prediabetes, and normal glycemic levels in Guangzhou, China: a cross-sectional study. Front Endocrinol (Lausanne). 2025 May 23;16:1518204. doi: 10.3389/fendo.2025.1518204. eCollection 2025.

  PMID: 40487765 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

All biological specimens (including blood, feces, urine, saliva and tongue coating) will be stored in the biological resource center of the our research centers after written informed consent obtained from all subjects who voluntarily participated in this clinical study.

MeSH Terms

Conditions

Chronic Disease; Neoplasms; Alzheimer Disease; Metabolic Diseases

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Nutritional and Metabolic Diseases

Central Study Contacts

Jianwen Guo, MD

CONTACT

+86-13724899379; 1308251832@qq.com

Bin Zhang, PhD

CONTACT

+86 18511308217; dochedy@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 11, 2022
• First Posted: April 7, 2022
• Study Start: June 6, 2022
• Primary Completion (Estimated): December 30, 2027
• Study Completion (Estimated): March 30, 2028
• Last Updated: November 15, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: After half year of the baseline and follow-ups data completing.
• Access Criteria: A professional qualification panel determines whether the visitor is qualified to view and use the repository.

Locations

CN (1)