Neural Correlates of Sensory Specific Satiety

NCT05313347 | Completed

• 1 other identifier: S-656/2019-2
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Sensory specific satiety, or the phenomenon that the pleasantness of a particular taste declines when certain types food are consumed to satiety, plays an important role in food choice and meal termination.The rewarding effect of sugar will be investigated in a group of 30 healthy participants with a body mass index ranging from 17.5 to 35kg/m2. A gustatory stimulation paradigm designed to induce sensory specific satiety for glucose will be employed. The aim is to assess neuronal stimulus processing in relation to the sensory satiety level and to investigate the relationship with everyday eating behavior.

Conditions

Satiety Response; Functional Neuroimaging; Obesity

Keywords

fmri; sensory specific satiety

Outcome Measures

Primary Outcomes (2)

• Choice of water compared to choice of sugar during Sensory Specific Satiety.

  Comparing tasting of water with tasting of sugar (G10%) when participants are allowed to freely chose between the two during specific satiety for sugar.

  1 hour

• Choice of water compared to passive ingestion of 20% sugar solution during Sensory Specific Satiety.

  Comparison of voluntary tasting of water with the "forced" tasting of sugar during specific satiety for sugar.

  1 hour

Secondary Outcomes (1)

• Influence of variations in BMI on brain activation during Sensory Specific Satiety.

  1 hour

Study Arms (1)

Healty Participants with varying BMI

30 healthy participants with a body mass index ranging from 17.5 to 35kg/m2.

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Healthy controls with BMI between 17,5 and 35 kg/m².

You may qualify if:

• BMI between 17,5 and 35 kg/m².
• Over age of 18 years.
• Right-handedness.
• Normal or corrected-to-normal vision.
• Capacity to consent.

You may not qualify if:

• History of head injury or surgery.
• History of neurological disorder.
• Severe psychiatric comorbidity.
• Lifetime or current medical illness that could potentially affect appetite or weight (including eating disorders diagnosis)
• Smoking.
• Current psychotropic medication.
• Inability to undergo fMRI scan (e.g. metallic implants, claustrophobia, pacemakers).
• Pregnancy.

Sponsors & Collaborators

• University of Heidelberg Medical Center: lead

Study Sites (1)

University Hospital Heidelberg

Heidelberg, Germany

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• joe simon, Ph.D.

  Heidelberg University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 28, 2022
• First Posted: April 6, 2022
• Study Start: February 1, 2022
• Primary Completion: July 1, 2023
• Study Completion: October 1, 2023
• Last Updated: November 29, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)