Left Ventricular Global Longitudinal Strain and Postoperative Myocardial Injury

NCT05392426 | Unknown DMC

• 1 other identifier: GLS and Myocardial injury
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 2

Brief Summary

To use left ventricular global longitudinal strain as a means of monitoring myocardial exercise function during anaesthesia in patients with coronary artery disease, to explore the association with the occurrence of postoperative myocardial injury, and to perform a predictive study of postoperative myocardial injury. The study was designed according to a prospective follow-up cohort.

Conditions

Postoperative Complications

Outcome Measures

Primary Outcomes (1)

• Postoperative high-sensitive troponin I change

  high-sensitive troponin I will be tested before and after surgery

  15 minutes after the ending of the surgery

Secondary Outcomes (2)

• Incidence of postoperative arrhythmia events

  from the ending of surgery to 72 hours after surgery

• Incidence of postoperative myocardial infarct events

  from the ending of surgery to 72 hours after surgery

Interventions

Left Ventricular Global Longitudinal Strain DEVICE

Left Ventricular Global Longitudinal Strain is collected from Speckle tracking imaging (STI) technique of echocardiography. This index is tested before and after the surgery.

EF CO SV EDV ESV DEVICE

Ejection fraction、cardiac output、stroke volume、end diastolic volume、end systolic volume. These indexes are collected before and after the surgery, using traditional echocardiography.

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

According to the European Heart Association's diagnostic criteria for chronic coronary syndrome in 2019, refers to the many stages of coronary heart disease other than the clinical manifestations dominated by acute coronary thrombosis.

You may qualify if:

• Age 65-90;
• According to the European Heart Association's diagnostic criteria for chronic coronary syndrome in 2019.Patients with suspected coronary heart disease and stable angina pectoris, with or without dyspnea; New heart failure or left ventricular dysfunction, suspected coronary heart disease; Patients with acute coronary syndrome who are asymptomatic or stable within one year of onset, or who will undergo revascularization in the near future;Patients with an initial diagnosis or revascularization for more than one year, with or without symptoms; Angina pectoris, suspected vasospasm, or microvascular disease patients; During screening, asymptomatic people with coronary heart disease were discovered;
• ASA II\~III; NYHA II\~III; require general anesthesia;
• no history of anesthetic allergy;
• agreed to participate in the study and signed the informed consent form.

You may not qualify if:

• Congenital heart disease, severe ventricular arrhythmia, atrial fibrillation, severe valvular regurgitation;
• Severe history of chronic obstructive pulmonary illness (COPD severity III or IV), individuals with severe or uncontrolled bronchial asthma, pulmonary infection, bronchiectasis;
• Patients with persistent drinking and known or suspected abusers of other narcotic analgesics;
• Obese (BMI 30 kg/m2)
• Cardiac surgical procedures are planned.

Sponsors & Collaborators

• The Second Affiliated Hospital of Chongqing Medical University: lead

Study Sites (2)

Department of Anesthesiology, The Second Affiliated Hospital, Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China

RECRUITING

The second affiliated hospital of Chongqing medical university

Chongqing, China

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

Venous blood will be collected for biochemical testing.

MeSH Terms

Conditions

Postoperative Complications

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• He Huang, MD

  The Second Affiliated Hospital, Chongqing Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Qiao Guo, MD

CONTACT

(+86)13637870013; guoqiao@cqmu.edu.cn

Dagang Wang, MD

CONTACT

+86 023 63693014; kuanrenlunli@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 18, 2022
• First Posted: May 26, 2022
• Study Start: May 30, 2022
• Primary Completion: December 30, 2022
• Study Completion: June 1, 2023
• Last Updated: June 21, 2022

Record last verified: 2022-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR
• Time Frame: Within five years

Locations

CN (2)