NCT05310188

Brief Summary

To estimate diagnostic levels of amylase, lipase, pseudocholinestrase and neutrophili lymphocytic ratio to different pesticide poisoning. In addition to detect prognostic values of theses enzymes \& NLR and its relation to the outcome of all pesticide poisoning. To assess descriptive sociodemographic criteria of these poisoned cases, mode of toxicity, type of pesticide poisoning at emergency room, any other associated toxicity as well as the clinical outcome.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
100

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Apr 2022

Shorter than P25 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 1, 2022

Completed
1 month until next milestone

Study Start

First participant enrolled

April 1, 2022

Completed
3 days until next milestone

First Posted

Study publicly available on registry

April 4, 2022

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2023

Completed
28 days until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2023

Completed
Last Updated

April 4, 2022

Status Verified

April 1, 2022

Enrollment Period

10 months

First QC Date

March 1, 2022

Last Update Submit

April 1, 2022

Conditions

Pesticide Poisoning

Keywords

cholinestereaselipaseamylaseNL ratio

Outcome Measures

Primary Outcomes (4)

  • Diagnostic and prognostic values of cholinesterase in acute pesticide poisoning cases

    clinical lab result of pseudocholinesterase

    baseline

  • diagnostic and prognostic value of amylase in acute pesticide poisoning cases

    blood level of amylase

    baseline

  • diagnostic and prognostic value of lipase in acute pesticide poisoning cases

    blood level of lipase

    baseline

  • diagnostic and prognostic value of neutrophil-to-lymphocyte ratio in acute pesticide poisoning case

    blood level of neutrophil-to-lymphocyte ratio

    baseline

Interventions

pseudocholinestereaseDIAGNOSTIC_TEST

blood samples

Also known as: lipase, NLR, amylase

Eligibility Criteria

Sexall
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

* Sociodemographic criteria: age, gender, residence, occupation, level of education, * Toxicity associated data: mode of exposure, time of exposure, symptoms appear, any measures done to reduce the toxicity before reaching the hospital * Medical history (HR, BP, kidney function, liver function and blood glucose level) * Clinical lab result of pseudocholinesterase, amylase, lipase and neutrophil-to-lymphocyte ratio at three times. * the first with 6 hrs. of admission * the second after 24 hrs. of the treatment regimen taken * the third after 48 hrs

You may qualify if:

  • All ages
  • Both sex
  • Any possible route of exposure to pesticides

You may not qualify if:

  • Exposure to medications or toxic chemicals other than pesticides.
  • Patients with chronic comorbidities, including liver cirrhosis, symptomatic heart failure, end stage CKD(on regular hemodialysis) and COPD.
  • Patients with gallstone history or DM
  • Recent abdominal trauma
  • Open abdominal surgery within one year ago

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (5)

  • Afzali S, Taheri SK, Seifrabiei M. Butyrylcholinesterase level in poisoned patients with phosphide compounds. Caspian J Intern Med. 2019 Fall;10(4):458-462. doi: 10.22088/cjim.10.4.458.

    PMID: 31814946BACKGROUND

  • Boedeker W, Watts M, Clausing P, Marquez E. The global distribution of acute unintentional pesticide poisoning: estimations based on a systematic review. BMC Public Health. 2020 Dec 7;20(1):1875. doi: 10.1186/s12889-020-09939-0.

    PMID: 33287770BACKGROUND

  • Mu Y, Hu B, Gao N, Pang L. Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning. Open Life Sci. 2021 Jul 15;16(1):703-710. doi: 10.1515/biol-2021-0069. eCollection 2021.

    PMID: 34307885BACKGROUND

  • Mehrpour O, Jafarzadeh M, Abdollahi M. A systematic review of aluminium phosphide poisoning. Arh Hig Rada Toksikol. 2012 Mar;63(1):61-73. doi: 10.2478/10004-1254-63-2012-2182.

    PMID: 22450207BACKGROUND

  • Dungdung A, Kumar A, Kumar B, Preetam M, Tara RK, Saba MK. Correlation and prognostic significance of serum amylase, serum lipase, and plasma cholinesterase in acute organophosphorus poisoning. J Family Med Prim Care. 2020 Apr 30;9(4):1873-1877. doi: 10.4103/jfmpc.jfmpc_205_20. eCollection 2020 Apr.

    PMID: 32670933BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood samples and serum

Study Officials

  • Doaa Mohammed Abd EL-Rahman, Ass.Prof

    Assiut University

    STUDY DIRECTOR

  • Hanan Sharaf El_Deen Mohammed, Ass.prof

    Assiut University

    STUDY DIRECTOR

Central Study Contacts

Asmaa AbouBakr Ahmed Ibrahim, Demonstrator

CONTACT

+201095978353asmaa.aboubakr99@gmail.com

Nagwa Mahmoud Ali Ghandour, Professor

CONTACT

+201099977236n_ghandour10@yahoo.com

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
director

Study Record Dates

First Submitted

March 1, 2022

First Posted

April 4, 2022

Study Start

April 1, 2022

Primary Completion

February 1, 2023

Study Completion

March 1, 2023

Last Updated

April 4, 2022

Record last verified: 2022-04