Evaluation of Pesticide Exposure in the General Population

NCT02986763 | Completed

• 1 other identifier: SIGEXPOSOME
• Study Type: observational
• Target: 166
• Locations: 0 countries
• Sites: N/A

Brief Summary

An association has been suggested with several diseases including cancer and IARC has classified several pesticides as carcinogenic, probably carcinogenic. There is a need for a better characterisation of environmental pesticides exposures and identification of suitable biomarkers of exposure and effect. A better understanding of the impact of pesticide exposure on metabolomic, transcriptomic and epigenetic changes, is essential to strengthen epidemiological hypotheses on the association with several cancer types. The main objective of the project is to validate a GIS (geographic information system) based method to assess environmental pesticide exposures, using environmental (contamination of housedust) and biological (blood and urine samples) measures. The project aims further to investigate a potential link between housedust contamination and biological measures in healthy non-smoking male residents and explore the impact of environmental pesticide exposure on metabolomics, transcriptomic and epigenetic parameters.

Conditions

Pesticide Poisoning

Outcome Measures

Primary Outcomes (1)

• level of pesticide exposures

  environmental, occupational and domestic exposures

  up to 2 years

Study Arms (2)

Professional pesticides

A specific questionnaire with professional information about pesticide uses is added for this arm Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling

Biological: Questionnaire, blood, urine, hair and dust samplings

Volunteers

Questionnaire to collect domestic pesticide use, diet, household characteristics Dust sampling Blood sampling Urine sampling Hair sampling

Biological: Questionnaire, blood, urine, hair and dust samplings

Interventions

Questionnaire, blood, urine, hair and dust samplings BIOLOGICAL

Professional pesticides; Volunteers

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy volunteers living in the Beaujolais region (France)

You may qualify if:

• Non smokers in the last two years Living in the Beaujolais region (France) within 1000m of vignards Informed consent signed

You may not qualify if:

• Volunteers sharing the same households with professional applicators of pesticides

Sponsors & Collaborators

• Centre Leon Berard: lead
• Cancéropôle Lyon Auvergne Rhône-Alpes: collaborator
• International Agency for Research on Cancer: collaborator
• Rovaltain Research Company: collaborator
• Centre de rechercher en Cancérologie de Lyon: collaborator

MeSH Terms

Interventions

Surveys and Questionnaires; Blood Specimen Collection; Urination

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Urinary Tract Physiological Phenomena; Reproductive and Urinary Physiological Phenomena

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2016
• First Posted: December 8, 2016
• Study Start: June 1, 2015
• Primary Completion: March 1, 2017
• Study Completion: March 1, 2017
• Last Updated: February 9, 2018

Record last verified: 2018-02