A Community Trial to Determine Whether 'Safe Storage' Reduces Pesticide Self-poisoning in Rural Asia

NCT01146496 | Completed Results DMC

• 1 other identifier: Safe Storage Protocol Sep09
• Study Type: interventional
• Target: 223,861
• Locations: 1 country
• Sites: 1

Brief Summary

A major global public health priority is to identify effective methods for preventing deaths from pesticide self-poisoning. The aim of this work is to determine whether the provision of lockable storage containers to poor households in rural Asia can reduce the incidence of intentional pesticide self-poisoning. Secondary questions include the effect of these containers on unintentional pesticide poisoning in children and overall self-harm.

Conditions

Pesticide Poisoning

Keywords

Pesticide poisoning; Suicide; Unintentional poisoning; Prevention; Cluster randomised controlled trial

Outcome Measures

Primary Outcomes (1)

• Incidence of Pesticide Self-poisoning

  Cases identified by survey of local and referral hospitals and by regular interview of primary informants in each village

  For three years after intervention

Secondary Outcomes (5)

• Incidence of All Self-poisoning

  For three years post-intervention

• Incidence of All Self-harm

  For three years after intervention

• Incidence of Fatal Self-harm

  For three years post intervention

• Incidence of Pesticide Poisoning

  For three years post intervention

• Incidence of Unintentional Paediatric Pesticide Poisoning

  For three years post intervention

Study Arms (2)

Storage container

ACTIVE COMPARATOR

Ultraviolet light resistant plastic in-ground pesticide storage container

Device: Ultraviolet light-resistant plastic in-ground pesticide storage container

Control

NO INTERVENTION

Interventions

Ultraviolet light-resistant plastic in-ground pesticide storage container DEVICE

In-ground pesticide storage container to be supplied to every household that uses pesticides in intervention villages

Storage container

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Any village in the study area that gives consent to the study

You may not qualify if:

• None

Sponsors & Collaborators

• University of Edinburgh: lead
• University of Bristol: collaborator
• University of Oxford: collaborator
• University of Peradeniya: collaborator
• University of Kelaniya: collaborator
• University of Copenhagen: collaborator

Study Sites (1)

Mahaweli H area

Anuradhapura, North Central Province, Sri Lanka

Location

Related Publications (4)

• Pearson M, Metcalfe C, Jayamanne S, Gunnell D, Weerasinghe M, Pieris R, Priyadarshana C, Knipe DW, Hawton K, Dawson AH, Bandara P, deSilva D, Gawarammana I, Eddleston M, Konradsen F. Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial. Lancet. 2017 Oct 21;390(10105):1863-1872. doi: 10.1016/S0140-6736(17)31961-X. Epub 2017 Aug 11.

  PMID: 28807536 DERIVED

• Knipe DW, Gunnell D, Pieris R, Priyadarshana C, Weerasinghe M, Pearson M, Jayamanne S, Dawson AH, Mohamed F, Gawarammana I, Hawton K, Konradsen F, Eddleston M, Metcalfe C. Is socioeconomic position associated with risk of attempted suicide in rural Sri Lanka? A cross-sectional study of 165 000 individuals. BMJ Open. 2017 Mar 22;7(3):e014006. doi: 10.1136/bmjopen-2016-014006.

  PMID: 28336743 DERIVED

• Madsen LB, Eddleston M, Hansen KS, Pearson M, Agampodi S, Jayamanne S, Konradsen F. Cost-effectiveness analyses of self-harm strategies aimed at reducing the mortality of pesticide self-poisonings in Sri Lanka: a study protocol. BMJ Open. 2015 Feb 27;5(2):e007333. doi: 10.1136/bmjopen-2014-007333.

  PMID: 25724984 DERIVED

• Pearson M, Konradsen F, Gunnell D, Dawson AH, Pieris R, Weerasinghe M, Knipe DW, Jayamanne S, Metcalfe C, Hawton K, Wickramasinghe AR, Atapattu W, Bandara P, de Silva D, Ranasinghe A, Mohamed F, Buckley NA, Gawarammana I, Eddleston M. A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka: study protocol. BMC Public Health. 2011 Nov 21;11:879. doi: 10.1186/1471-2458-11-879.

  PMID: 22104027 DERIVED

MeSH Terms

Conditions

Suicide

Condition Hierarchy (Ancestors)

Self-Injurious Behavior; Behavioral Symptoms; Behavior

Results Point of Contact

• Title: Michael Eddleston
• Organization: University of Edinburgh

m.eddleston@ed.ac.uk

01312426776

Study Officials

• Michael Eddleston

  University of Edinburgh

  PRINCIPAL INVESTIGATOR

• Flemming Konradsen

  University of Copenhagen

  STUDY DIRECTOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2010
• First Posted: June 17, 2010
• Study Start: December 1, 2010
• Primary Completion: May 1, 2013
• Study Completion: June 1, 2016
• Last Updated: July 18, 2019
• Results First Posted: July 5, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

SR (1)