Acute Time-Restricted Eating in Young Healthy Males

NCT05309798 | Completed

• 1 other identifier: WM_eFAST_2020
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

This study compared the metabolic response to three different eating windows (morning fast,12pm-8pm; evening fast, 8am-4pm; control, 8am-8pm).

Conditions

Obesity Prevention

Keywords

Chrononutrition; Time-Restricted Eating; Energy Balance; Glycaemic Control

Outcome Measures

Primary Outcomes (1)

• Glycaemic Control

  A metabolic assessment lasting 3.5 hours will take place following a standardised, laboratory-based meal. The investigators will be taking periodic capillary and venous blood samples to measure post-prandial glucose and insulin, which together comprise 'glycaemic control'.

  0 hour (Pre breakfast), 1 hour, 2 hour, 3.5 hour

Secondary Outcomes (7)

• Energy Intake

  3.5 hour following breakfast

• Energy expenditure

  Activity recorded across day 1 standardisation and day 2 (lab visit and post lab visit)

• Visual analogue scale for subjective ratings of appetite

  0 hour (pre-breakfast), 1 hour, 2 hour, 3 hour, 4 hour (post breakfast during lab visit)

• Acylated Ghrelin (Appetite hormone)

  0 hour (pre breakfast), 1 hour, 2 hour, and 3 hour post breakfast

• PYY (Appetite hormone)

  0 hour (pre-breakfast), 1 hour, 2 hour, and 3 hour post breakfast

Study Arms (3)

Evening Fasting

EXPERIMENTAL

Participants will undertake acute evening fasting (feeding between 8am-4pm)

Behavioral: Evening Fasting

Control

EXPERIMENTAL

Participants will undertake an acute standard western feeding pattern (feeding between 8am-8pm).

Behavioral: Control

Morning Fasting

EXPERIMENTAL

Participants will undertake an acute morning fasting trial (feeding between 12pm-8pm).

Behavioral: Morning Fasting

Interventions

Evening Fasting BEHAVIORAL

Participants will undertake acute evening fasting (feeding between 8am-4pm) for one day. After which they will attend the laboratory, following a 16 h fast, where baseline measures will be taken and the response to a standardised meal will take place. The participant will also have an opportunity to feed ad-libitum before they leave the laboratory.

Evening Fasting

Morning Fasting BEHAVIORAL

Participants will undertake an acute morning fasting trial (feeding between 12pm-8pm). After which, participants will visit the laboratory the following day, after a 16 h fast, where baseline measures will be taken and the response to a standardised meal will take place. The participant will also have an opportunity to feed ad-libitum before they leave the laboratory.

Morning Fasting

Control BEHAVIORAL

Participants will undertake an acute standard western feeding pattern (feeding between 8am-8pm). After which, participants will visit the laboratory the following day, after a 12 h fast, where baseline measures will be taken and the response to a standardised meal will take place. The participant will also have an opportunity to feed ad-libitum before they leave the laboratory.

Control

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• recreationally active
• non-smokers
• non-dieting
• weight stable (self-reported for \>6 months)
• were not consuming any medication known to affect appetite or physical activity

You may not qualify if:

• Smokers
• \>10 hours per week physical activity
• Have dieted within the past 6 months
• Excessive alcohol consumption (\>14 units/week)
• Use of medication or supplements that may affect hormone concentrations.

Sponsors & Collaborators

• Nottingham Trent University: lead
• Loughborough University: collaborator

Study Sites (1)

Nottingham Trent University

Nottingham, Nottinghamshire, NG2 5BL, United Kingdom

Location

Related Publications (8)

• Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 2018 Jun 5;27(6):1212-1221.e3. doi: 10.1016/j.cmet.2018.04.010. Epub 2018 May 10.

  PMID: 29754952 RESULT

• Jamshed H, Beyl RA, Della Manna DL, Yang ES, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans. Nutrients. 2019 May 30;11(6):1234. doi: 10.3390/nu11061234.

  PMID: 31151228 RESULT

• Ravussin E, Beyl RA, Poggiogalle E, Hsia DS, Peterson CM. Early Time-Restricted Feeding Reduces Appetite and Increases Fat Oxidation But Does Not Affect Energy Expenditure in Humans. Obesity (Silver Spring). 2019 Aug;27(8):1244-1254. doi: 10.1002/oby.22518.

  PMID: 31339000 RESULT

• Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S, Heilbronn LK. Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial. Obesity (Silver Spring). 2019 May;27(5):724-732. doi: 10.1002/oby.22449. Epub 2019 Apr 19.

  PMID: 31002478 RESULT

• Templeman I, Gonzalez JT, Thompson D, Betts JA. The role of intermittent fasting and meal timing in weight management and metabolic health. Proc Nutr Soc. 2020 Feb;79(1):76-87. doi: 10.1017/S0029665119000636. Epub 2019 Apr 26.

  PMID: 31023390 RESULT

• Popkin BM. The nutrition transition and obesity in the developing world. J Nutr. 2001 Mar;131(3):871S-873S. doi: 10.1093/jn/131.3.871S.

  PMID: 11238777 RESULT

• Allison KC, Goel N. Timing of eating in adults across the weight spectrum: Metabolic factors and potential circadian mechanisms. Physiol Behav. 2018 Aug 1;192:158-166. doi: 10.1016/j.physbeh.2018.02.047. Epub 2018 Feb 24.

  PMID: 29486170 RESULT

• St-Onge MP, Ard J, Baskin ML, Chiuve SE, Johnson HM, Kris-Etherton P, Varady K; American Heart Association Obesity Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Clinical Cardiology; and Stroke Council. Meal Timing and Frequency: Implications for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association. Circulation. 2017 Feb 28;135(9):e96-e121. doi: 10.1161/CIR.0000000000000476. Epub 2017 Jan 30.

  PMID: 28137935 RESULT

MeSH Terms

Conditions

Intermittent Fasting

Condition Hierarchy (Ancestors)

Fasting; Feeding Behavior; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Model Details: The study design is a randomised, controlled, crossover design in which participants undertake three conditions in a randomised order with at least one week in between trials.

Study Record Dates

• First Submitted: March 16, 2022
• First Posted: April 4, 2022
• Study Start: January 14, 2019
• Primary Completion: December 13, 2019
• Study Completion: December 13, 2019
• Last Updated: April 4, 2022

Record last verified: 2022-03

Locations

GB (1)