Respiratory Muscle Fatigue at Different Breathing Modes

NCT05393115 | Unknown

• 1 other identifier: Eso_pres_fatigue
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims at investigating if time to respiratory muscle fatigue and metabolism are influenced by the pressure wave form mode applied during resistive breathing.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Time to task failure (Tlim)

  The time (s) from the subject starts to breathe under the experimental condition, and until task failure will be measured. Task failure is defied by either subject intolerance to continue or by lacking ability of the subject to maintain the target pressure and/or timing. From a previous publication (Bellemare and Grassino, JAP, 1982), it is estimated that subjects will reach Tlim between 30min to 1 hour. If breathing is continued after 1 hour, task failure will not happen as breathing can be continued indefinitely.

  Up to two months between the two different breathing trials (randomized order)

Secondary Outcomes (8)

• Respiratory muscle pressures

  Up to two months between the two different breathing trials (randomized order)

• Tidal volume

  Up to two months between the two different breathing trials (randomized order)

• Respiratory work

  Up to two months between the two different breathing trials (randomized order)

• Ratings of perceived exertion

  Up to two months between the two different breathing trials (randomized order)

• Metabolism

  Up to two months between the two different breathing trials (randomized order)

Interventions

Square wave breathing OTHER

difference in time to failure from the two breathing modes

Also known as: Triangle wave breathing

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy men or women
• Age ≥18 and ≤60 years
• BMI ≥ 20 and ≤30

You may not qualify if:

• Drug addiction defined as the use of cannabis, opioids or other drugs
• Previous and present neurologic (e.g. ataxia), musculoskeletal (e.g. muscular dystrophy) or mental illnesses (e.g. schizophrenia)
• History of mechanical ventilation, COVID-19 with respiratory complications, lung cancer
• Part of lung resected
• Presence of dyspepsia/heart-burn/abdominal pain
• Presence of esophageal varices
• Presence of liver disease
• Presence of esophageal hernia
• Pregnancy
• Failure to comply with transcranial magnetic stimulation adult safety screen
• History of epilepsy, metal implants in head or jaw
• Acute or chronic lung diseases, e.g. asthma, COPD, bronchitis etc.
• Lack of ability to cooperate

Sponsors & Collaborators

• Aalborg University: lead

Study Sites (1)

Mathias Krogh Poulsen

Aalborg, Danmark, 9220, Denmark

RECRUITING

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Teaching Associate Professor

Study Record Dates

• First Submitted: April 21, 2022
• First Posted: May 26, 2022
• Study Start: October 1, 2021
• Primary Completion: December 1, 2022
• Study Completion: December 1, 2022
• Last Updated: May 26, 2022

Record last verified: 2022-05

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)